Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.36 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.34 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.34 |
| ▸ | CCR5 known ✓ | P51681 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.33 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1071467 | 0.83 | MAPT (0.37) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| Hydrochloric Acid SCHEMBL1072266 | 0.81 | PSMD14 (0.37) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| Hydrochloric Acid SCHEMBL1071823 | 0.80 | MAPT (0.37) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| Hydrochloric Acid SCHEMBL5009056 | 0.75 | ALDH1A1 (0.37) | MAPTKDM4ETDP1TSHRMMP2 | |
| SCHEMBL7194064 | 0.70 | MAPT (0.44) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| Hydrochloric Acid SCHEMBL1072118 | 0.70 | KDM4E (0.40) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| Hydrochloric Acid SCHEMBL4452823 | 0.68 | MAPT (0.38) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| SCHEMBL6131343 | 0.65 | MAPT (0.36) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| SCHEMBL5270898 | 0.64 | CCR1 (0.38) | MAPTKDM4EGAAMAPK1APOBEC3G | |
| SCHEMBL762337 | 0.62 | KDM4E (0.54) | MAPTKDM4EGAAMAPK1APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618912-B2 | Preparation of supported catalyst systems | BASELL POLYOLEFINE GMBH (DE) | 2009-11-17 | — | — | US | claimed |
| US-20060166813-A1 | Preparation of supported catalyst systems | BASELL POLYOLEFINE GMBH (DE) | 2006-07-27 | — | — | US | claimed |
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| EP-1740626-B1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE | BASELL POLYOLEFINE GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-1861409-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-7834107-B2 | Preparation of polyolefins having high molecular weights in the presence of an organic transition metal compound in a gas-phase fluidized-bed reactor | BASELL POLYOLEFINE GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| US-7834112-B2 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| US-7795167-B2 | Cyclopentadienyl complexes of group 6 substituted by silyl halides | BASELL POLYOLEFINE GMBH (DE) | 2010-09-14 | — | — | US | disclosed |
| US-7776980-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1572359-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2010-04-28 | — | — | EP | disclosed |
| EP-1569968-B1 | PREPARATION OF CATALYST COMPOSITIONS HAVING IMPROVED ACTIVITY | BASELL POLYOLEFINE GMBH (DE) | 2010-03-17 | — | — | EP | disclosed |
| US-20040249095-A1 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | BASELL POLYOLEFINE GMBH (DE) | 2004-12-02 | — | — | US | disclosed |
| US-6787498-B2 | AS CATALYSTS FOR POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2004-09-07 | — | — | US | disclosed |
| US-6699948-B2 | AS CATALYSTS FOR POLYMERIZATION OF OLEFINS | BASF AKTIENGESELLSCHAFT (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20040033890-A1 | Catalyst system for carrying out olefin polymerization comprising a calcined hydro-talcite serving as a supporting material | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2004-02-19 | — | — | US | disclosed |
| US-20030176275-A1 | Catalytic solid supported on calcined hydrotalcite for olefinic polymerisation | BASELL POLYOLEFINE GMBH (DE) | 2003-09-18 | — | — | US | disclosed |
| US-20030036662-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | MIHAN SHAHRAM (DE) | 2003-02-20 | — | — | US | disclosed |
| US-20030036658-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | MIHAN SHAHRAM (DE) | 2003-02-20 | — | — | US | disclosed |
| US-6437161-B1 | OLEFIN POLYMERIZATION CATALYSTS; SUBSTITUENT ON THE CYCLOPENTADIENYL RING CARRIES A DONOR FUNCTION WHICH IS BONDED RIGIDLY, NOT EXCLUSIVELY VIA SP3-HYBRIDIZED CARBON OR SILICON ATOMS, | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | MCM4, MCM3, CCNC | GAA 4522/4885CA2 4344/4885HSP90AA1 3659/4885 |
| US-20030036662-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | SKIC3, ORC3, MCM3 | GAA 4825/4885CA2 2872/4885HSP90AA1 4656/4885 |
| US-20030036658-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | SKIC3, ORC3, MCM3 | GAA 4825/4885CA2 2872/4885HSP90AA1 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.