Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.53 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MC5R | P33032 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MC1R | Q01726 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6251238 | 1.00 | IFNAR1 (0.64) | IFNAR1CA2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL681401 | 0.98 | IFNAR1 (0.66) | IFNAR1CA2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL29434746 | 0.98 | IFNAR1 (0.66) | IFNAR1CA2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL5321295 | 0.98 | IFNAR1 (0.66) | IFNAR1CA2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL14110952 | 0.84 | IFNAR1 (0.51) | IFNAR1CA2CYP1A2CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL30725687 | 0.81 | IFNAR1 (0.97) | IFNAR1CYP1A2CYP2C19CYP2D6MEN1 | |
| Isophthalic Acid SCHEMBL27488646 | 0.81 | POLB (0.54) | IFNAR1MEN1KMT2ALMNARECQL | |
| SCHEMBL6008064 | 0.80 | MC5R (0.70) | CA2CYP1A2CYP2C19CYP2D6MEN1 | |
| SCHEMBL3144929 | 0.80 | IFNAR1 (0.51) | IFNAR1CA2MEN1KMT2AMC5R | |
| Hydrochloric Acid SCHEMBL27581438 | 0.80 | MTNR1A (0.61) | IFNAR1CYP1A2CYP2C19CYP2D6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112552182-B | New synthesis process of naftifine drug intermediate N-methyl-1-naphthylmethylamine | 杭州新桂实业有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-112552182-A | New synthesis process of naftifine drug intermediate N-methyl-1-naphthylmethylamine | 杭州新桂实业有限公司 | 2021-03-26 | — | — | CN | claimed |
| US-20200131431-A1 | CHEMICAL ADDITIVES AND SURFACTANT COMBINATIONS FOR FAVORABLE WETTABILITY ALTERATION AND IMPROVED HYDROCARBON RECOVERY FACTORS | ALCHEMY SCIENCES INC (US) | 2020-04-30 | — | — | US | claimed |
| US-20060084826-A1 | Process for the preparation of naphthylmethylamine derivatives | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-04-20 | — | — | US | claimed |
| CN-112552182-B | New synthesis process of naftifine drug intermediate N-methyl-1-naphthylmethylamine | 杭州新桂实业有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-115073303-A | Preparation method of terbinafine hydrochloride Z-type isomer | 乐泰药业(兰西)有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-111606811-B | Preparation method of terbinafine hydrochloride | 山东安弘制药有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114105774-A | Preparation method of N-methyl-1-naphthylmethylamine | 河北海力香料股份有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-113788761-A | Method and system for refining medical intermediate | 丽江映华生物药业有限公司 | 2021-12-14 | — | — | CN | disclosed |
| CN-108164423-B | Preparation method of naftifine hydrochloride | 福建金山准点制药有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-112552182-A | New synthesis process of naftifine drug intermediate N-methyl-1-naphthylmethylamine | 杭州新桂实业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-111606811-A | Preparation method of terbinafine hydrochloride | 山东安弘制药有限公司 | 2020-09-01 | — | — | CN | disclosed |
| US-6306959-B1 | Rapid purification by polymer supported quench | WARNER LAMBERT COMPANY | 2001-10-23 | — | — | US | disclosed |
| WO-2000039055-A1 | RAPID PURIFICATION BY POLYAROMATIC QUENCH REAGENTS | WARNER-LAMBERT COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-0896590-A1 | RAPID PURIFICATION BY POLYMER SUPPORTED QUENCH | WARNER-LAMBERT COMPANY (US) | 1999-02-17 | — | — | EP | disclosed |
| US-5817875-A | Methods for the manufacture of terbinafine | KARIMIAN KHASHAYAR (CA) | 1998-10-06 | — | — | US | disclosed |
| WO-1997042230-A1 | RAPID PURIFICATION BY POLYMER SUPPORTED QUENCH | WARNER-LAMBERT COMPANY (US) | 1997-11-13 | — | — | WO | disclosed |
| US-4822822-A | FUNGICIDES FOR PLANTS AND ANIMALS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0221781-A2 | Benzylamine derivatives, process for production thereof, and use thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1987-05-13 | — | — | EP | disclosed |
| US-4282251-A | FUNGICIDES | SANDOZ LTD. (CH) | 1981-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084826-A1 | Process for the preparation of naphthylmethylamine derivatives | NAT1, NPM1, REN | CA2 3932/4885IFNAR1 366/4885CYP1A2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.