SCHEMBL12232015

SCHEMBL12232015

CC(C)CCCCOCC(C)C

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.43
SPHK1 Q9NYA1 2/20 0.41
SPHK2 Q9NRA0 1/20 0.41
USP2 O75604 1/20 0.34
HTT P42858 1/20 0.33
RARB P10826 1/20 0.33
CYP3A4 P08684 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B10 Q99714 1/20 0.32
PLA2G2C Q5R387 1/20 0.32
CYP1A2 P05177 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10120811 0.97 SPHK1 (0.44) LMNASPHK1SPHK2USP2HTT
SCHEMBL25940118 0.97 SPHK1 (0.44) LMNASPHK1SPHK2USP2HTT
SCHEMBL10119363 0.97 SPHK1 (0.44) LMNASPHK1SPHK2USP2HTT
SCHEMBL7866199 0.97 SPHK1 (0.44) LMNASPHK1SPHK2USP2HTT
SCHEMBL25565580 0.93 SPHK1 (0.41) LMNASPHK1SPHK2USP2HTT
SCHEMBL10498220 0.93 SPHK1 (0.41) LMNASPHK1SPHK2USP2HTT
SCHEMBL26719977 0.92 SPHK1 (0.37) LMNASPHK1SPHK2USP2HTT
SCHEMBL12031279 0.92 LMNA (0.39) LMNASPHK1SPHK2USP2HTT
SCHEMBL11858528 0.89 SPHK1 (0.42) SPHK1SPHK2USP2HTTCYP3A4
SCHEMBL16248567 0.87 LMNA (0.36) LMNASPHK1SPHK2CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240238435-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY DYNE THERAPEUTICS, INC. (US) 2024-07-18 US disclosed
US-20240216522-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FRIEDREICH'S ATAXIA DYNE THERAPEUTICS, INC. (US) 2024-07-04 US disclosed
US-20240209119-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING DYSTROPHINOPATHIES DYNE THERAPEUTICS, INC. (US) 2024-06-27 US disclosed
US-20240066140-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY DYNE THERAPEUTICS, INC. (US) 2024-02-29 US disclosed
US-20240016952-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY DYNE THERAPEUTICS, INC. (US) 2024-01-18 US disclosed
US-11839660-B2 Anti-transferrin receptor antibody and uses thereof DYNE THERAPEUTICS, INC. (US) 2023-12-12 US disclosed
US-20230357270-A1 TETRAHYDROISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF RED BLOOD DISORDERS AND INFLAMMATORY DISEASES SANOFI (FR) 2023-11-09 US disclosed
US-20230346967-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING DYSTROPHINOPATHIES DYNE THERAPEUTICS, INC. (US) 2023-11-02 US disclosed
US-20230330562-A1 METHODS OF PREPARING PROTEIN-OLIGONUCLEOTIDE COMPLEXES DYNE THERAPEUTICS, INC. (US) 2023-10-19 US disclosed
US-20230321264-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY DYNE THERAPEUTICS, INC. (US) 2023-10-12 US disclosed
US-20080167311-A1 Prostaglandin Prodrugs ALLERGAN, INC. 2008-07-10 US disclosed
US-20080119539-A1 THERAPEUTIC AMIDES ALLERGAN, INC. 2008-05-22 US disclosed
US-20080119538-A1 THERAPEUTIC COMPOUNDS ALLERGAN, INC. 2008-05-22 US disclosed
US-20080058397-A1 5-(3-(3-(4-hexanoylphenyl)-2,5-dioxoimidazolidin-4-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agent; post-sergical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts OLD DAVID W 2008-03-06 US disclosed
US-20080058387-A1 5-(3-(3-(4-(1-hydroxyhexyl)phenyl)-4-oxo-thiazolidin-2-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agents; post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts ALLERGAN, INC. 2008-03-06 US disclosed
US-20080051374-A1 Therapeutic Amides and related Compounds ALLERGAN, INC. 2008-02-28 US disclosed
US-20080045576-A1 THERAPEUTIC N-ARYL OR N-HETEROARYL PYRAZOLIDINE AND PYRAZOLIDINONE DERIVATIVES ALLERGAN, INC. 2008-02-21 US disclosed
US-20080039505-A1 THERAPEUTIC LACTAMS ALLERGAN, INC. 2008-02-14 US disclosed
US-20080027108-A1 THERAPEUTIC SUBSTITUTED LACTAMS ALLERGAN, INC. 2008-01-31 US disclosed
US-20080015231-A1 THERAPEUTIC COMPOUNDS ALLERGAN, INC. 2008-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (20 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240016952-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY MUSK, MYOF, MYLK2 LMNA 373/4885SPHK1 1685/4885SPHK2 1476/4885
US-20080051374-A1 Therapeutic Amides and related Compounds GOT2, ACER2, GOT1 LMNA 3216/4885SPHK1 2288/4885SPHK2 1593/4885
US-11839660-B2 Anti-transferrin receptor antibody and uses thereof TFRC, FTH1, FOLR1 LMNA 4703/4885SPHK1 3870/4885SPHK2 3920/4885
US-20080027108-A1 THERAPEUTIC SUBSTITUTED LACTAMS SI, GGPS1, B3GAT3 LMNA 3131/4885SPHK1 2118/4885SPHK2 2610/4885
US-20080119539-A1 THERAPEUTIC AMIDES GOT2, GOT1, ARG2 LMNA 3086/4885SPHK1 2821/4885SPHK2 2218/4885
US-20230321264-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY MUSK, MYOF, UTRN LMNA 1506/4885SPHK1 3891/4885SPHK2 3709/4885
US-20080039505-A1 THERAPEUTIC LACTAMS CLPP, NOTUM, PEPD LMNA 3171/4885SPHK1 3821/4885SPHK2 4094/4885
US-20230357270-A1 TETRAHYDROISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF RED BLOOD DISORDERS AND INFLAMMATORY DISEASES NFE2L2, KEAP1, NFE2 LMNA 2526/4885SPHK1 1900/4885SPHK2 1394/4885
US-20080167311-A1 Prostaglandin Prodrugs PTGES, PTGIS, PTGER1 LMNA 1925/4885SPHK1 531/4885SPHK2 422/4885
US-20240216522-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FRIEDREICH'S ATAXIA MUSK, ATXN2, ATXN10 LMNA 464/4885SPHK1 3677/4885SPHK2 3122/4885
US-20080045576-A1 THERAPEUTIC N-ARYL OR N-HETEROARYL PYRAZOLIDINE AND PYRAZOLIDINONE DERIVATIVES GOT2, GOT1, NME4 LMNA 935/4885SPHK1 960/4885SPHK2 642/4885
US-20240066140-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY MUSK, MYOF, UTRN LMNA 1506/4885SPHK1 3891/4885SPHK2 3709/4885
US-20080058397-A1 5-(3-(3-(4-hexanoylphenyl)-2,5-dioxoimidazolidin-4-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agent; post-sergical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts PTGIS, PTGIR, PTGS1 LMNA 983/4885SPHK1 435/4885SPHK2 266/4885
US-20080058387-A1 5-(3-(3-(4-(1-hydroxyhexyl)phenyl)-4-oxo-thiazolidin-2-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agents; post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts PTGIS, PTGIR, PTGS1 LMNA 1226/4885SPHK1 1072/4885SPHK2 845/4885
US-20240209119-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING DYSTROPHINOPATHIES UTRN, MUSK, SMN1; SMN2 LMNA 359/4885SPHK1 4017/4885SPHK2 3846/4885
US-20230330562-A1 METHODS OF PREPARING PROTEIN-OLIGONUCLEOTIDE COMPLEXES PHAX, RAB5IF, CD2BP2 LMNA 2858/4885SPHK1 4832/4885SPHK2 4773/4885
US-20080119538-A1 THERAPEUTIC COMPOUNDS GOT2, ANXA5, GOT1 LMNA 1806/4885SPHK1 2531/4885SPHK2 2064/4885
US-20240238435-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY MUSK, MYOF, MYLK2 LMNA 373/4885SPHK1 1685/4885SPHK2 1476/4885
US-20080015231-A1 THERAPEUTIC COMPOUNDS GOT2, ANXA5, COXFA4L2 LMNA 2115/4885SPHK1 1800/4885SPHK2 1461/4885
US-20230346967-A1 MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING DYSTROPHINOPATHIES UTRN, MUSK, MYOF LMNA 372/4885SPHK1 3946/4885SPHK2 3710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.