Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169502 | 0.98 | TSHR (0.45) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL1636583 | 0.85 | TSHR (0.52) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL1636584 | 0.85 | TSHR (0.52) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL5654625 | 0.85 | TSHR (0.52) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL37916 | 0.79 | TSHR (0.47) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL7521766 | 0.79 | TSHR (0.47) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL453100 | 0.79 | TSHR (0.47) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL10606524 | 0.79 | TSHR (0.47) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL16767717 | 0.78 | TSHR (0.42) | TSHRTHRBALDH1A1TDP1POLB | |
| SCHEMBL472711 | 0.78 | TSHR (0.45) | TSHRTHRBALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251363-B1 | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide | DU PONT (US) | 2012-12-26 | — | — | EP | claimed |
| EP-2054452-B1 | POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE | DU PONT (US) | 2012-09-19 | — | — | EP | claimed |
| EP-2287270-A2 | Composition containing fluorinated amide | E. I. du Pont de Nemours and Company (US) | 2011-02-23 | — | — | EP | claimed |
| EP-2251363-A1 | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide | E. I. du Pont de Nemours and Company (US) | 2010-11-17 | — | — | EP | claimed |
| US-7754838-B2 | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-07-13 | — | — | US | claimed |
| EP-2054452-A2 | POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-05-06 | — | — | EP | claimed |
| EP-2035619-A2 | METHOD OF PROVIDING REPELLENCY | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-03-18 | — | — | EP | claimed |
| EP-1940906-A2 | TRIAZOLE-CONTAINING FLUORINATED POLYMERS | E.I. du Pont de Nemours and Company (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2008021153-A2 | POLY(METH)ACRYLAMIDES AND POLY(METH)ACRYLATES CONTAINING FLUORINATED AMIDE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-02-21 | — | — | WO | claimed |
| US-20080039605-A1 | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide | E. I. DU PONT DE NEMOURS AND COMPANY | 2008-02-14 | — | — | US | claimed |
| WO-2008005209-A2 | METHOD OF PROVIDING REPELLENCY | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-10 | — | — | WO | claimed |
| US-20080004394-A1 | Method of providing repellency | E. I. DU PONT DE NEMOURS AND COMPANY | 2008-01-03 | — | — | US | claimed |
| WO-2007035936-A2 | TRIAZOLE-CONTAINING FLUORINATED POLYMERS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-03-29 | — | — | WO | claimed |
| US-20070066762-A1 | Triazole-containing fluorinated polymers | E. I. DU PONT DE NEMOURS AND COMPANY | 2007-03-22 | — | — | US | claimed |
| CN-107709477-B | Durable architectural coatings comprising crosslinkable polymeric additives | 科慕埃弗西有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-107810242-B | Ethylenic cross-linkable fluorinated polymer additives for architectural coatings | 科慕埃弗西有限公司 | 2021-08-27 | — | — | CN | disclosed |
| EP-3289025-B1 | DURABLE ARCHITECTURAL COATINGS CONTAINING CROSSLINKABLE POLYMERIC ADDITIVES | CHEMOURS CO TT LLC (US) | 2019-11-13 | — | — | EP | disclosed |
| US-4201840-A | Photographic film units containing a polymeric mordant which covalently bonds with certain dyes | EASTMAN KODAK COMPANY (US) | 1980-05-06 | — | — | US | disclosed |
| US-4193795-A | FOR DIFFUSION TRANSFER PROCESSES | EASTMAN KODAK COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4178221-A | Process for the preparation of water-soluble acrylic polymers by photopolymerization | RHONE-POULENC INDUSTRIES (FR) | 1979-12-11 | — | — | US | disclosed |