SCHEMBL139952

SCHEMBL139952

CCCCCCCCCCCCCCCCCCC(O)(CCCCCCCCCCCCCCCCCC)C(O)CO

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.41
FDPS P14324 8/20 0.41
GGPS1 O95749 5/20 0.41
CYP2D6 P10635 2/20 0.39
SPHK1 Q9NYA1 1/20 0.39
GMNN O75496 1/20 0.39
POLB P06746 1/20 0.39
THPO P40225 1/20 0.39
MTOR P42345 1/20 0.39
BLM P54132 1/20 0.39
KDM4E B2RXH2 1/20 0.39
TP53 P04637 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
CETP P11597 1/20 0.39
HTT P42858 1/20 0.39
UBE2N P61088 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28434703 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL18863212 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL1890334 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL5820256 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL25815 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL142854 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL2226505 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL5963212 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL136611 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1
SCHEMBL29064953 1.00 LMNA (0.41) LMNAFDPSGGPS1CYP2D6SPHK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 180 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117384055-B Ionizable lipids for delivery of therapeutic agents and uses thereof 仁景(苏州)生物科技有限公司 2024-11-19 CN claimed
WO-2024222243-A1 IONIZABLE LIPID FOR DELIVERY OF THERAPEUTIC AGENT AND USE THEREOF 仁景(苏州)生物科技有限公司 2024-10-31 WO claimed
CN-118813629-A MRNA for expressing aquaporin AQP3 and application thereof 北京键凯科技股份有限公司 2024-10-22 CN claimed
CN-118767154-A Multi-arm polyethylene glycol drug conjugate and application thereof 北京键凯科技股份有限公司 2024-10-15 CN claimed
CN-118742292-A Liposome composition and pharmaceutical composition containing liposome 卫材R&D管理有限公司 2024-10-01 CN claimed
CN-117947024-A SiRNA sequence for effectively inhibiting expression of complement C3 factor and application thereof 北京键凯科技股份有限公司 2024-04-30 CN claimed
CN-117866955-A Interference RNA for inhibiting expression of melanin avidin (MLPH) gene and application thereof 北京键凯科技股份有限公司 2024-04-12 CN claimed
CN-117487823-A Respiratory syncytial virus mRNA vaccine and preparation method and application thereof 怡道生物科技(苏州)有限公司 2024-02-02 CN claimed
CN-117384055-A Ionizable lipids for delivery of therapeutic agents and uses thereof 仁景(苏州)生物科技有限公司 2024-01-12 CN claimed
CN-117286143-A Interfering RNA for inhibiting TUBB2 gene expression and application thereof 北京键凯科技股份有限公司 2023-12-26 CN claimed
US-10260071-B2 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2019-04-16 US claimed
US-20160348115-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity PFIZER INC. 2016-12-01 US claimed
EP-2078080-B1 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY COLEY PHARM GMBH (DE) 2015-06-17 EP claimed
US-20140163213-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity COLEY PHARMACEUTICAL GMBH (DE) 2014-06-12 US claimed
EP-2057904-B1 Structured lipid compositions KRAFT FOODS GLOBAL BRANDS LLC (US) 2012-04-25 EP claimed
WO-2011119058-A2 F3-PEPTIDE TARGETED LIPID-BASED NANOPARTICLES USEFUL FOR THE TREATMENT OF ANGIOGENESIS-DEPENDENT DISEASES UNIVERSIDADE DE COIMBRA (PT) 2011-09-29 WO claimed
US-20100166780-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity PFIZER INC 2010-07-01 US claimed
EP-2078080-A2 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceuticals GmbH (DE) 2009-07-15 EP claimed
WO-2008068638-A2 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY COLEY PHARMACEUTICAL GMBH (DE) 2008-06-12 WO claimed
CN-122079802-A Cationic lipids and compositions thereof 2026-05-26 CN disclosed
US-12569570-B2 Compositions and methods for targeted RNA delivery VERVE THERAPEUTICS, INC. (US) 2026-03-10 US disclosed
EP-4606388-A9 METAL-POLYPHENOL COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF Hunan Lonstar Biotech Co., Ltd. (CN) 2026-02-25 EP disclosed
US-20260048142-A1 METAL-CHELATED POLYPHENOL COMPLEX NANOPARTICLE, DRUG-LIPID PARTICLE, PREPARATION METHODS FOR THE SAME, AND USES THEREOF HUNAN LONSTAR BIOTECH CO LTD (CN) 2026-02-19 US disclosed
EP-4678177-A1 ARENAVIRUS VACCINE The University of Osaka (JP) 2026-01-14 EP disclosed
EP-4606388-A1 METAL-POLYPHENOL COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF Hunan Lonstar Biotech Co., Ltd. (CN) 2025-08-27 EP disclosed
CN-115745788-B Ionizable lipid compound, and preparation method and application thereof 国家纳米科学中心 2025-06-24 CN disclosed
EP-4570271-A1 METAL-PHOSPHOLIPID COMPLEX, METAL-PHOSPHOLIPID COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF Hunan Lonstar Biotech Co., Ltd. (CN) 2025-06-18 EP disclosed
CN-120078734-A Lipid nanoparticle for delivering nucleic acid and preparation method and application thereof 康希诺(上海)生物研发有限公司 2025-06-03 CN disclosed
US-12274753-B2 Compositions and methods for targeted RNA delivery VERVE THERAPEUTICS, INC. (US) 2025-04-15 US disclosed
CN-119546285-A Freeze-dried composition of lipid nanoparticles with nucleic acids encapsulated therein 日油株式会社 2025-02-28 CN disclosed
CN-119504707-A Ionizable lipid compounds capable of activating STING signal pathway and application thereof 四川大学 2025-02-25 CN disclosed
CN-119345352-A Engineered cell composition and preparation method and application thereof 山东汇泽生物制药有限公司 2025-01-24 CN disclosed
CN-119343153-A Nucleic acid medicine for treating hyperuricemia related diseases and preparation method and application thereof 北京炫景瑞医药科技有限公司 2025-01-21 CN disclosed
CN-119285480-A Modified amine lipids 英特利亚治疗股份有限公司 2025-01-10 CN disclosed
CN-119234042-A Messenger ribonucleic acid with prolonged half-life 摩登纳特斯有限公司 2024-12-31 CN disclosed
CN-119136789-A Method for producing nucleic acid-encapsulated lipid nanoparticle, method for producing pharmaceutical composition comprising same, and method for introducing nucleic acid into cells or target cells 日油株式会社 2024-12-13 CN disclosed
CN-117384055-B Ionizable lipids for delivery of therapeutic agents and uses thereof 仁景(苏州)生物科技有限公司 2024-11-19 CN disclosed
CN-118973618-A Agents and methods for targeted delivery of nucleic acids to cells 生物技术欧洲股份公司 2024-11-15 CN disclosed
CN-118973619-A Agents and methods for targeted delivery to cells 生物技术欧洲股份公司 2024-11-15 CN disclosed
WO-2024222243-A1 IONIZABLE LIPID FOR DELIVERY OF THERAPEUTIC AGENT AND USE THEREOF 仁景(苏州)生物科技有限公司 2024-10-31 WO disclosed
CN-117487823-B Respiratory syncytial virus mRNA vaccine and preparation method and application thereof 怡道生物科技(苏州)有限公司 2024-10-29 CN disclosed
CN-118834136-A Ionizable lipid compound and application thereof 上海桢曜生物科技合伙企业(有限合伙) 2024-10-25 CN disclosed
CN-118829625-A Novel ionizable lipids and lipid nanoparticles and methods of use thereof 赛欧生物医药股份有限公司 2024-10-22 CN disclosed
CN-118813629-A MRNA for expressing aquaporin AQP3 and application thereof 北京键凯科技股份有限公司 2024-10-22 CN disclosed
CN-118767154-A Multi-arm polyethylene glycol drug conjugate and application thereof 北京键凯科技股份有限公司 2024-10-15 CN disclosed
CN-118742292-A Liposome composition and pharmaceutical composition containing liposome 卫材R&D管理有限公司 2024-10-01 CN disclosed
US-20240316212-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. 2024-09-26 US disclosed
CN-118660960-A Polynucleotides, compositions and methods for genome editing 因特利亚治疗公司 2024-09-17 CN disclosed
CN-118613585-A Modified guide RNAs for gene editing 因特利亚治疗公司 2024-09-06 CN disclosed
CN-118401495-A Method for purifying composition JSR株式会社 2024-07-26 CN disclosed
CN-118384268-A Methods of treating subjects having Hepatitis B Virus (HBV) infection 阿尔尼拉姆医药品有限公司 2024-07-26 CN disclosed
CN-118369111-A Herpes simplex virus mRNA vaccine 摩登纳特斯有限公司 2024-07-19 CN disclosed
CN-118302157-A Lipid nanoparticles with cell targeting 日油株式会社 2024-07-05 CN disclosed
CN-118221556-A Ionizable cationic lipid material, and preparation method and application thereof 南京吉迈生物技术有限公司 2024-06-21 CN disclosed
EP-4380576-A2 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY Verve Therapeutics, Inc. (US) 2024-06-12 EP disclosed
CN-118125932-A Application of ionizable lipid molecules and nanoparticle composition thereof in nucleic acid delivery 北京启辰生生物科技有限公司 2024-06-04 CN disclosed
CN-118105475-A Lyophilized preparation of mRNA lipid nanoparticle of 2019-nCoV delta strain S protein mutant 北京启辰生生物科技有限公司 2024-05-31 CN disclosed
CN-118078752-A Lipid composition for gene editing agent delivery and uses thereof 北京启辰生生物科技有限公司 2024-05-28 CN disclosed
CN-118103514-A Cyclic RNA compositions and methods 欧纳医疗公司 2024-05-28 CN disclosed
CN-118059222-A Lyophilized preparation of mRNA lipid nanoparticle of 2019-nCoV S protein 北京启辰生生物科技有限公司 2024-05-24 CN disclosed
CN-118059059-A Freeze-dried preparation of lipid nano particles 北京启辰生生物科技有限公司 2024-05-24 CN disclosed
CN-118021754-A Needleless injector and lipid nanoparticle delivery system 北京启辰生生物科技有限公司 2024-05-14 CN disclosed
CN-117947024-A SiRNA sequence for effectively inhibiting expression of complement C3 factor and application thereof 北京键凯科技股份有限公司 2024-04-30 CN disclosed
CN-114728886-B Lipid compounds and compositions containing carbonates for intracellular delivery of therapeutic agents 摩登纳特斯有限公司 2024-04-12 CN disclosed
US-20240100169-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. 2024-03-28 US disclosed
CN-117731805-A Lipid nanoparticle formulations for CRISPR/CAS components 因特利亚治疗公司 2024-03-22 CN disclosed
WO-2024032507-A1 METAL-PHOSPHOLIPID COMPLEX, METAL-PHOSPHOLIPID COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF 湖南健瑞医药科技有限公司 2024-02-15 WO disclosed
WO-2024032482-A1 METAL-POLYPHENOL COMPLEX PARTICLE, DRUG-LIPID PARTICLE, METHOD FOR PREPARING SAME, AND USE THEREOF 湖南健瑞医药科技有限公司 2024-02-15 WO disclosed
CN-117534585-A Novel ionizable cationic lipid compound, and preparation method and application thereof 国家纳米科学中心 2024-02-09 CN disclosed
CN-117487823-A Respiratory syncytial virus mRNA vaccine and preparation method and application thereof 怡道生物科技(苏州)有限公司 2024-02-02 CN disclosed
CN-113699151-B Hepatitis B Virus (HBV) iRNA compositions and methods of use thereof 阿尔尼拉姆医药品有限公司 2024-01-19 CN disclosed
CN-117384055-A Ionizable lipids for delivery of therapeutic agents and uses thereof 仁景(苏州)生物科技有限公司 2024-01-12 CN disclosed
CN-117377653-A Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents 摩登纳特斯有限公司 2024-01-09 CN disclosed
CN-117321417-A Method for determining the efficacy of therapeutic cell compositions 朱诺治疗学股份有限公司 2023-12-29 CN disclosed
CN-113039174-B Ionizable amine lipids 英特利亚治疗股份有限公司 2023-11-17 CN disclosed
US-11801306-B2 Compositions and methods for targeted RNA delivery VERVE THERAPEUTICS, INC. (US) 2023-10-31 US disclosed
CN-116916896-A Method for preparing lipid nanoparticles 摩登纳特斯有限公司 2023-10-20 CN disclosed
CN-116507344-A Compositions and methods for inducing an immune response against coronaviruses 伊莱西奥治疗有限公司 2023-07-28 CN disclosed
CN-116133652-A Method for preparing lipid nanoparticles 摩登纳特斯有限公司 2023-05-16 CN disclosed
CN-116113419-A Cyclic RNA compositions and methods 奥纳治疗公司 2023-05-12 CN disclosed
CN-116034114-A Cyclic RNA compositions and methods 奥纳治疗公司 2023-04-28 CN disclosed
CN-116018403-A In vitro cell delivery methods 因特利亚治疗公司 2023-04-25 CN disclosed
WO-2023015223-A9 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. (US) 2023-04-06 WO disclosed
WO-2023015223-A2 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. (US) 2023-02-09 WO disclosed
EP-4114360-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY Verve Therapeutics, Inc. (US) 2023-01-11 EP disclosed
EP-4074344-A1 TARGETING LIPIDS Arbutus Biopharma Corporation (CA) 2022-10-19 EP disclosed
CN-114746398-A Headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents 摩登纳特斯有限公司 2022-07-12 CN disclosed
US-20220152210-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. 2022-05-19 US disclosed
US-11207416-B2 Compositions and methods for targeted RNA delivery VERVE THERAPEUTICS, INC. (US) 2021-12-28 US disclosed
US-20210299261-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. 2021-09-30 US disclosed
WO-2021178725-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. (US) 2021-09-10 WO disclosed
US-20210177757-A1 EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS PURETECH LYT, INC. (US) 2021-06-17 US disclosed
US-10260071-B2 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2019-04-16 US disclosed
US-20180193270-A1 EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS PURETECH LYT, INC. 2018-07-12 US disclosed
US-9814777-B2 Targeting lipids ARBUTUS BIOPHARMA CORPORATION (CA) 2017-11-14 US disclosed
EP-3156077-A1 TARGETING LIPIDS Arbutus Biopharma Corporation (CA) 2017-04-19 EP disclosed
EP-2231195-B1 TARGETING LIPIDS ARBUTUS BIOPHARMA CORP (CA) 2017-03-29 EP disclosed
US-20160375137-A9 TARGETING LIPIDS TEKMIRA PHARMACEUTICALS CORPORATION (CA) 2016-12-29 US disclosed
US-20160348115-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity PFIZER INC. 2016-12-01 US disclosed
US-9453222-B2 Ligand-conjugated monomers ALNYLAM PHARMACEUTICALS, INC. (US) 2016-09-27 US disclosed
US-9382545-B2 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2016-07-05 US disclosed
EP-2990410-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals Inc. (US) 2016-03-02 EP disclosed
EP-2960332-A1 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceutical GmbH (DE) 2015-12-30 EP disclosed
EP-2567693-B1 Lipid encapsulated interfering RNA PROTIVA BIOTHERAPEUTICS INC (CA) 2015-10-21 EP disclosed
EP-1791567-B1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS INC (US) 2015-07-29 EP disclosed
US-20150191726-A1 LIGAND-CONJUGATED MONOMERS BANK OF AMERICA, N.A. 2015-07-09 US disclosed
EP-2078080-B1 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY COLEY PHARM GMBH (DE) 2015-06-17 EP disclosed
US-8957223-B2 Ligand-conjugated monomers ALNYLAM PHARMACEUTICALS, INC. (US) 2015-02-17 US disclosed
US-8911813-B2 Structured lipid compositions INTERCONTINENTAL GREAT BRANDS LLC (US) 2014-12-16 US disclosed
EP-1648519-B1 LIPID ENCAPSULATED INTERFERING RNA PROTIVA BIOTHERAPEUTICS INC (CA) 2014-10-08 EP disclosed
US-20140179761-A1 TARGETING LIPIDS TEKMIRA PHARMACEUTICALS CORPORATION (CA) 2014-06-26 US disclosed
US-20140163213-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity COLEY PHARMACEUTICAL GMBH (DE) 2014-06-12 US disclosed
US-8580268-B2 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2013-11-12 US disclosed
US-8575380-B2 Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome NOF CORPORATION (JP) 2013-11-05 US disclosed
US-20130280408-A1 Structured Lipid Compositions INTERCONTINENTAL GREAT BRANDS LLC (US) 2013-10-24 US disclosed
US-8507661-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2013-08-13 US disclosed
US-20130184328-A1 LIGAND-CONJUGATED MONOMERS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-07-18 US disclosed
US-8486478-B2 Structured lipid compositions International Great Brands LLC (US) 2013-07-16 US disclosed
US-20130116461-A1 BRANCHED POLYETHYLENE GLYCOL LINKED WITH DIACYL GLYCEROL, PROCESS FOR PRODUCING THE SAME, AND POLYETHYLENE GLYCOL MODIFIED LIPOSOME NOF CORPORATION (JP) 2013-05-09 US disclosed
WO-2013054298-A2 MODIFIED POLYETHYLENE GLYCOLS AND THEIR SUPRAMOLECULAR COMPLEXES WITH BIOLOGICALLY ACTIVE MACROMOLECULES Bio-Ker S.r.l (IT) 2013-04-18 WO disclosed
US-8404862-B2 Ligand-conjugated monomers ALNYLAM PHARMACEUTICALS, INC. (US) 2013-03-26 US disclosed
EP-2567693-A1 Lipid encapsulated interfering RNA Protiva Biotherapeutics Inc. (CA) 2013-03-13 EP disclosed
EP-2462811-A1 Structured lipid compositions Kraft Foods Global Brands LLC (US) 2012-06-13 EP disclosed
EP-2057904-B1 Structured lipid compositions KRAFT FOODS GLOBAL BRANDS LLC (US) 2012-04-25 EP disclosed
US-20120058188-A1 LIPID ENCAPSULATED INTERFERING RNA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2012-03-08 US disclosed
US-20110305770-A1 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM ENZON PHARMACEUTICALS, INC. (US) 2011-12-15 US disclosed
US-20110269942-A1 ANTIBODIES MODIFIED WITH HYDROPHOBIC MOLECULE DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-11-03 US disclosed
WO-2011119058-A2 F3-PEPTIDE TARGETED LIPID-BASED NANOPARTICLES USEFUL FOR THE TREATMENT OF ANGIOGENESIS-DEPENDENT DISEASES UNIVERSIDADE DE COIMBRA (PT) 2011-09-29 WO disclosed
US-20110223257-A1 RELEASABLE FUSOGENIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS ENZON PHARMACEUTICALS, INC. (US) 2011-09-15 US disclosed
EP-2362728-A1 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM Enzon Pharmaceuticals, Inc. (US) 2011-09-07 EP disclosed
EP-2355799-A1 RELEASABLE FUSOGENIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS Enzon Pharmaceuticals, Inc. (US) 2011-08-17 EP disclosed
US-7982027-B2 silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell; hepatitis PROTIVA BIOTHERAPEUTICS, INC. (CA) 2011-07-19 US disclosed
WO-2010057160-A9 RELEASABLE FUSOGENIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS ENZON PHARMACEUTICALS, INC. (US) 2011-05-05 WO disclosed
US-20100292455-A1 MODIFIED iRNA AGENTS ALNYLAM PHARMACEUTICALS (US) 2010-11-18 US disclosed
US-20100279990-A1 ANTIPROLIFERATIVE COMPOUNDS, COMPOSITIONS AND METHODS OF USE RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2010-11-04 US disclosed
US-7807815-B2 Compositions comprising immunostimulatory siRNA molecules and DLinDMA or DLenDMA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2010-10-05 US disclosed
EP-2231195-A2 TARGETING LIPIDS Alnylam Pharmaceuticals Inc. (US) 2010-09-29 EP disclosed
US-20100166780-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity PFIZER INC 2010-07-01 US disclosed
US-7745608-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2010-06-29 US disclosed
US-20100130549-A1 PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2010-05-27 US disclosed
WO-2010057150-A1 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS ENZON PHARMACEUTICALS, INC. (US) 2010-05-20 WO disclosed
WO-2010057160-A1 RELEASABLE FUSOGENIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS ENZON PHARMACEUTICALS, INC. (US) 2010-05-20 WO disclosed
EP-2184355-A1 ANTIBODY MODIFIED WITH HYDROPHOBIC MOLECULE Daiichi Sankyo Company, Limited (JP) 2010-05-12 EP disclosed
EP-2120907-A1 PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE Ramot at Tel-Aviv University Ltd (IL) 2009-11-25 EP disclosed
US-20090286973-A1 LIGAND-CONJUGATED MONOMERS ALNYLAM PHARMACEUTICALS, INC. (US) 2009-11-19 US disclosed
US-20090247608-A1 Targeting Lipids ALNYLAM PHARMACEUTICALS, INC. (US) 2009-10-01 US disclosed
US-7582744-B2 containing 2'-O-methyl modified nucleoside; oligonucleotide having a nucleotide sequence consisting of from 12 to 23 nucleotides in length sufficiently complementary to a microRNA target sequence of about 12 to 23 nucleotides, conjugate with a cholesterol or steroid; for inhibiting gene expression ALNYLAM PHARMACEUTICALS, INC. (US) 2009-09-01 US disclosed
EP-2078080-A2 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceuticals GmbH (DE) 2009-07-15 EP disclosed
WO-2009082607-A2 TARGETING LIPIDS ALNYLAM PHARMACEUTICALS, INC. (US) 2009-07-02 WO disclosed
US-20090142362-A1 Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP) AVANT IMMUNOTHERAPEUTICS, INC. (US) 2009-06-04 US disclosed
US-20090123635-A1 Structured Lipid Compositions INTERCONTINENTAL GREAT BRANDS LLC 2009-05-14 US disclosed
EP-2057904-A1 Structured lipid compositions Kraft Foods Global Brands LLC (US) 2009-05-13 EP disclosed
EP-2029517-A2 ANTIPROLIFERATIVE COMPOUNDS, COMPOSITIONS AND METHODS OF USE Ramot at Tel-Aviv University Ltd. (IL) 2009-03-04 EP disclosed
WO-2008057529-A9 PEPTIDE-BASED VACCINE COMPOSITIONS TO ENDOGENOUS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) COLEY PHARM GROUP INC (US) 2008-07-24 WO disclosed
WO-2008084484-A1 PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE RAMOT AT TEL-AVIV UNIVERSITY LTD (IL) 2008-07-17 WO disclosed
WO-2008068638-A2 CPG OLIGONUCLEOTIDE ANALOGS CONTAINING HYDROPHOBIC T ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY COLEY PHARMACEUTICAL GMBH (DE) 2008-06-12 WO disclosed
WO-2008057529-A2 PEPTIDE-BASED VACCINE COMPOSITIONS TO ENDOGENOUS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-05-15 WO disclosed
WO-2007146796-A2 ANTIPROLIFERATIVE COMPOUNDS, COMPOSITIONS AND METHODS OF USE RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2007-12-21 WO disclosed
EP-1791567-A2 CHEMICALLY MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals Inc. (US) 2007-06-06 EP disclosed
EP-1773857-A1 IMMUNOSTIMULATORY SIRNA MOLECULES AND USES THEREFOR Protiva Biotherapeutics Inc. (CA) 2007-04-18 EP disclosed
US-20060240093-A1 LIPID ENCAPSULATED INTERFERING RNA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2006-10-26 US disclosed
EP-1648519-A2 LIPID ENCAPSULATED INTERFERING RNA Protiva Biotherapeutics Inc. (CA) 2006-04-26 EP disclosed
US-20060058266-A1 containing 2'-O-methyl modified nucleoside; oligonucleotide having a nucleotide sequence consisting of from 12 to 23 nucleotides in length sufficiently complementary to a microRNA target sequence of about 12 to 23 nucleotides, conjugate with a cholesterol or steroid; for inhibiting gene expression BANK OF AMERICA, N.A. 2006-03-16 US disclosed
US-20060051405-A1 Compositions for the delivery of therapeutic agents and uses thereof PROTIVA BIOTHERAPEUTICS, INC. (CA) 2006-03-09 US disclosed
WO-2006020768-A2 CHEMICALLY MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2006-02-23 WO disclosed
US-20060025366-A1 Immunostimulatory siRNA molecules and uses therefor PROTIVA BIOTHERAPEUTICS, INC. (GB) 2006-02-02 US disclosed
WO-2006007712-A1 METHODS COMPRISING POLYETHYLENE GLYCOL-LIPID CONJUGATES FOR DELIVERY OF THERAPEUTIC AGENTS PROTIVA BIOTHERAPEUTICS, INC. (CA) 2006-01-26 WO disclosed
WO-2006002538-A1 IMMUNOSTIMULATORY SIRNA MOLECULES AND USES THEREFOR PROTIVA BIOTHERAPEUTICS, INC. (CA) 2006-01-12 WO disclosed
US-20050107325-A1 Conjugated lipophilic group with a modified nucleotide is used to target disease gene, cells, tissue, for drug delivery to entrance into tumor cells; ribose sugar of nucleotide is replaced with a cyclic carrier which has at least one attached phosphate or phosphorothioate group; antitumor biodrugs ALNYLAM PHARMACEUTICALS, INC. 2005-05-19 US disclosed
US-20050064595-A1 Lipid encapsulated interfering RNA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2005-03-24 US disclosed
WO-2005007196-A2 LIPID ENCAPSULATED INTERFERING RNA PROTIVA BIOTHERAPEUTICS, INC. (CA) 2005-01-27 WO disclosed
WO-2002102169-A2 SYNTHETIC FAT COMPOSITION THIXO LTD. (IL) 2002-12-27 WO disclosed
US-20020132035-A1 Synthetic fat composition TAMARKIN DOV (IL) 2002-09-19 US disclosed
EP-0571724-B1 Stabilizer for phospholipid vesicles CHIBA FLOUR MILLING (JP) 1997-06-04 EP disclosed
US-5472951-A Containing lipopolysaccharide having hydrophobic group linked through an amide linkage to a stereoisomeric carbon at a reducing end group of an aldose CHIBA FLOUR MILLING CO., LTD. (JP) 1995-12-05 US disclosed
EP-0571724-A1 Stabilizer for phospholipid vesicles CHIBA FLOUR MILLING CO. LTD. (JP) 1993-12-01 EP disclosed
EP-0321548-A4 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES 1991-01-30 EP disclosed
US-4904582-A Novel amphiphilic nucleic acid conjugates SYNTHETIC GENETICS (US) 1990-02-27 US disclosed
EP-0321548-A1 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES SYNTHETIC GENETICS (US) 1989-06-28 EP disclosed
WO-1988009810-A1 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES SYNTHETIC GENETICS (US) 1988-12-15 WO disclosed
WO-1988009810-A1 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES SYNTHETIC GENETICS (US) 1988-12-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (32 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12274753-B2 Compositions and methods for targeted RNA delivery PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20180193270-A1 EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS EXOSC5, EXOSC9, EXOSC10 LMNA 3167/4885FDPS 4415/4885GGPS1 3264/4885
US-20090247608-A1 Targeting Lipids LY96, ABHD10, APOB LMNA 180/4885FDPS 1893/4885GGPS1 872/4885
US-20100279990-A1 ANTIPROLIFERATIVE COMPOUNDS, COMPOSITIONS AND METHODS OF USE STRA6, GPR6, CCNO LMNA 3449/4885FDPS 3786/4885GGPS1 3031/4885
US-20060058266-A1 containing 2'-O-methyl modified nucleoside; oligonucleotide having a nucleotide sequence consisting of from 12 to 23 nucleotides in length sufficiently complementary to a microRNA target sequence of about 12 to 23 nucleotides, conjugate with a cholesterol or steroid; for inhibiting gene expression NSUN2, RNMT, RNGTT LMNA 2496/4885FDPS 1386/4885GGPS1 471/4885
US-20240100169-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20110305770-A1 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM KPNA6, LPAR6, KAT6B LMNA 276/4885FDPS 3395/4885GGPS1 1683/4885
US-20130184328-A1 LIGAND-CONJUGATED MONOMERS TNFSF11, BCDIN3D, CD40LG LMNA 3599/4885FDPS 2341/4885GGPS1 1659/4885
US-20210177757-A1 EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS EXOSC5, EXOSC9, EXOSC10 LMNA 3167/4885FDPS 4415/4885GGPS1 3264/4885
US-20110223257-A1 RELEASABLE FUSOGENIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS FUS, HNRNPUL2, HNRNPDL LMNA 530/4885FDPS 1064/4885GGPS1 1100/4885
US-20100292455-A1 MODIFIED iRNA AGENTS NCL, HNRNPA0, HNRNPA1 LMNA 56/4885FDPS 1225/4885GGPS1 811/4885
US-20050064595-A1 Lipid encapsulated interfering RNA ABHD16A, LDLR, RNASE1 LMNA 1007/4885FDPS 2172/4885GGPS1 619/4885
US-20150191726-A1 LIGAND-CONJUGATED MONOMERS TNFSF11, BCDIN3D, CD40LG LMNA 3599/4885FDPS 2341/4885GGPS1 1659/4885
US-20120058188-A1 LIPID ENCAPSULATED INTERFERING RNA ABHD16A, LDLR, RNASE1 LMNA 1007/4885FDPS 2172/4885GGPS1 619/4885
US-20140179761-A1 TARGETING LIPIDS LY96, ABHD10, APOB LMNA 169/4885FDPS 1928/4885GGPS1 879/4885
US-12569570-B2 Compositions and methods for targeted RNA delivery LDLR, ASGR1, PCSK9 LMNA 63/4885FDPS 4013/4885GGPS1 1626/4885
US-20100130549-A1 PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE SLC6A2, CHRNA6, SLC6A3 LMNA 3494/4885FDPS 4655/4885GGPS1 4038/4885
US-20060240093-A1 LIPID ENCAPSULATED INTERFERING RNA ABHD16A, LDLR, RNASE1 LMNA 1007/4885FDPS 2172/4885GGPS1 619/4885
US-20100166780-A1 CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity TLR9, TYMP, STING1 LMNA 4419/4885FDPS 1275/4885GGPS1 528/4885
US-10260071-B2 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity TLR9, TYMP, STING1 LMNA 4419/4885FDPS 1275/4885GGPS1 528/4885
US-20240316212-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY PCSK9, LDLR, PCSK7 LMNA 135/4885FDPS 2396/4885GGPS1 2053/4885
US-20060051405-A1 Compositions for the delivery of therapeutic agents and uses thereof PNLIP, SGPL1, PLTP LMNA 1788/4885FDPS 448/4885GGPS1 168/4885
US-20220152210-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20090142362-A1 Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP) CETP, PCTP, LCAT LMNA 2968/4885FDPS 420/4885GGPS1 277/4885
US-11207416-B2 Compositions and methods for targeted RNA delivery PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20260048142-A1 METAL-CHELATED POLYPHENOL COMPLEX NANOPARTICLE, DRUG-LIPID PARTICLE, PREPARATION METHODS FOR THE SAME, AND USES THEREOF HAMP, ELP1, LIPC LMNA 1077/4885FDPS 1591/4885GGPS1 2673/4885
US-20050107325-A1 Conjugated lipophilic group with a modified nucleotide is used to target disease gene, cells, tissue, for drug delivery to entrance into tumor cells; ribose sugar of nucleotide is replaced with a cyclic carrier which has at least one attached phosphate or phosphorothioate group; antitumor biodrugs LDLR, SLC29A1, SLC29A2 LMNA 295/4885FDPS 1287/4885GGPS1 594/4885
US-20210299261-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20090286973-A1 LIGAND-CONJUGATED MONOMERS TNFSF11, BCDIN3D, CD40LG LMNA 3599/4885FDPS 2341/4885GGPS1 1659/4885
US-11801306-B2 Compositions and methods for targeted RNA delivery PCSK9, LDLR, PCSK7 LMNA 127/4885FDPS 3130/4885GGPS1 1855/4885
US-20060025366-A1 Immunostimulatory siRNA molecules and uses therefor HAVCR2, CD74, STING1 LMNA 4187/4885FDPS 2135/4885GGPS1 673/4885
US-20160375137-A9 TARGETING LIPIDS LY96, ABHD10, APOB LMNA 169/4885FDPS 1928/4885GGPS1 879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.