Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.34 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.34 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.32 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.30 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865548 | 0.97 | MMP1 (0.36) | DNM1MMP1MMP2MMP3MMP8 | |
| Bromide SCHEMBL31364322 | 0.94 | DNM1 (0.38) | DNM1MMP1MMP2MMP3MMP8 | |
| Water SCHEMBL28587222 | 0.94 | TSHR (0.35) | DNM1MMP1MMP2MMP3MMP8 | |
| SCHEMBL865701 | 0.92 | FDPS (0.36) | DNM1MMP1MMP2MMP3MMP8 | |
| SCHEMBL865718 | 0.92 | DNM1 (0.43) | DNM1MMP1MMP2MMP3MMP8 | |
| Hydrochloric Acid SCHEMBL3027494 | 0.89 | DNM1 (0.52) | DNM1TSHRCA12CA1CA9 | |
| Hydrochloric Acid SCHEMBL27746543 | 0.89 | DNM1 (0.52) | DNM1TSHRCA12CA1CA9 | |
| SCHEMBL10379743 | 0.89 | DNM1 (0.48) | DNM1TSHRCA12CA1CA9 | |
| SCHEMBL11252414 | 0.89 | DNM1 (0.48) | DNM1TSHRCA12CA1CA9 | |
| SCHEMBL3309868 | 0.88 | DNM1 (0.46) | DNM1TSHRLMNACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5961770-A | HEATING A MIXTURE OF A POLYDIORGANOSILOXANE, A SILICONE RESIN COPOLYMER, AND AN ORGANIC AMINE COMPOUND OR SALT THEREOF, AND THEN ADDING AN ORGANIC PEROXIDE OR AZO COMPOUND TO THE RESULTANT REACTION PRODUCT. | DOW CORNING CORPORATION (US) | 1999-10-05 | — | — | US | claimed |
| US-5869556-A | PREPARED BY HEATING MIXTURE OF POLYSILOXANE, SOLUBLE SILICONE RESIN COPOLYMER, ORGANIC AMINE, ADDING ORGANIC PEROXIDE OR AZO COMPOUND | DOW CORNING CORPORATION (US) | 1999-02-09 | — | — | US | claimed |
| CN-107779091-B | Organosiloxane compositions and coatings, articles, methods and uses | 美国陶氏有机硅公司 | 2020-05-19 | — | — | CN | disclosed |
| US-9926410-B2 | Organosiloxane compositions and coatings, manufactured articles, methods and uses | DOW CORNING CORPORATION (US) | 2018-03-27 | — | — | US | disclosed |
| EP-2978795-B1 | ORGANOSILOXANE COMPOSITIONS AND COATINGS, MANUFACTURED ARTICLES, METHODS AND USES | DOW CORNING (US) | 2017-05-31 | — | — | EP | disclosed |
| EP-2470588-B1 | PROCESS FOR THE PREPARATION OF A SILICONE PRESSURE-SENSITIVE ADHESIVE | DOW CORNING (US) | 2016-04-27 | — | — | EP | disclosed |
| US-20160053056-A1 | ORGANOSILOXANE COMPOSITIONS AND COATINGS, MANUFACTURED ARTICLES, METHODS AND USES | DOW SILICONES CORPORATION | 2016-02-25 | — | — | US | disclosed |
| EP-2978795-A1 | ORGANOSILOXANE COMPOSITIONS AND COATINGS, MANUFACTURED ARTICLES, METHODS AND USES | Dow Corning Corporation (US) | 2016-02-03 | — | — | EP | disclosed |
| CN-102549047-B | For the preparation of the method for silicone pressure-sensitive adhesive | DOW CORNING CORP. (US) | 2016-01-20 | — | — | CN | disclosed |
| CN-105229056-A | Organosiloxane compositions and coatings, articles, methods and uses | DOW CORNING | 2016-01-06 | — | — | CN | disclosed |
| US-9175198-B2 | Process for the preparation of a silicone pressure-sensitive adhesive | DOW CORNING CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| CN-1254232-C | Topical compositions containing fluid-absorbent solids and adhesive fluids | PROCTER & GAMBLE (US) | 2006-05-03 | — | — | CN | disclosed |
| CN-1558750-A | Topical compositions containing fluid-absorbent solids and adhesive fluids | — | 2004-12-29 | — | — | CN | disclosed |
| EP-0867493-B1 | Silicone pressure sensitive adhesive compositions | DOW CORNING (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-0816464-B1 | Silicone pressure sensitive adhesive compositions | DOW CORNING (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5961770-A | HEATING A MIXTURE OF A POLYDIORGANOSILOXANE, A SILICONE RESIN COPOLYMER, AND AN ORGANIC AMINE COMPOUND OR SALT THEREOF, AND THEN ADDING AN ORGANIC PEROXIDE OR AZO COMPOUND TO THE RESULTANT REACTION PRODUCT. | DOW CORNING CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| US-5916981-A | PRESSURE SENSITIVE ADHESIVES OF POLYSILOXANES AND CATALYSTS | DOW CORNING CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |
| US-5869556-A | PREPARED BY HEATING MIXTURE OF POLYSILOXANE, SOLUBLE SILICONE RESIN COPOLYMER, ORGANIC AMINE, ADDING ORGANIC PEROXIDE OR AZO COMPOUND | DOW CORNING CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0867493-A2 | Silicone pressure sensitive adhesive compositions | DOW CORNING CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0816464-A2 | Silicone pressure sensitive adhesive compositions | DOW CORNING CORPORATION (US) | 1998-01-07 | — | — | EP | disclosed |