Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.49 |
| ▸ | TTR known ✓ | P02766 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15723570 | 0.98 | ALDH1A1 (0.63) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL30892482 | 0.98 | ALDH1A1 (0.63) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL10942341 | 0.87 | ALDH1A1 (0.71) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL30979260 | 0.87 | ALDH1A1 (0.71) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL10930822 | 0.85 | ALDH1A1 (0.58) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28623609 | 0.84 | GPR35 (0.56) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL11809474 | 0.83 | L3MBTL1 (0.59) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL70180 | 0.82 | GPR35 (0.58) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL17059243 | 0.80 | ALDH1A1 (0.58) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 | |
| SCHEMBL4699370 | 0.80 | ALDH1A1 (0.86) | ALDH1A1CYP3A4MAPK1ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601646-B | 4 [6 (methyl mercapto) benzo [1,2 d:5,4 d '] two [base of 1,3] oxazoles 2] benzoic acid preparation method | 南通大学 | 2017-10-17 | — | — | CN | claimed |
| CN-105601646-A | Preparation method for 4-[6-(methylthio) benzo [1,2-d:5,4-d'] bis [1,3] oxazole-2-radical] benzoic acid | UNIV NANTONG | 2016-05-25 | — | — | CN | claimed |
| CN-104098589-B | 4- [6- (methylthio) benzo [1,2-d:5, 4-d' ] di [1,3] oxazole-2-yl ] benzoic acid and preparation method thereof | NANTONG UNIVERSITY (CN) | 2016-05-04 | — | — | CN | claimed |
| CN-103664622-B | The monomer of AB type hydroxyl modification superpolymer and intermediate thereof and preparation method | JIANG University OF TECHNOLOGY (CN) | 2016-01-13 | — | — | CN | claimed |
| CN-104119534-A | Polyhydroxy-p-phenylene benzodioxazole polymer and preparation and application thereof | JIN NINGREN | 2014-10-29 | — | — | CN | claimed |
| CN-104098589-A | 4- [6- (methylthio) benzo [1,2-d:5,4-d' ] di [1,3] oxazole-2-yl ] benzoic acid and preparation method thereof | UNIV NANTONG | 2014-10-15 | — | — | CN | claimed |
| CN-103664622-A | Monomers and intermediates of AB type hydroxyl modified high polymer and preparation methods of monomers and intermediates | UNIV ZHEJIANG TECHNOLOGY | 2014-03-26 | — | — | CN | claimed |
| CN-1326831-C | 4-amino-6-nitro resorcin hydrochloride, and its preparation and use | UNIV ZHEJIANG TECHNOLOGY (CN) | 2007-07-18 | — | — | CN | claimed |
| CN-1275950-C | AB type poly(p-phenyl) benzdioxan monomer and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-09-20 | — | — | CN | claimed |
| CN-1709858-A | 4-amino-6-nitro resorcin hydrochloride, and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-12-21 | — | — | CN | claimed |
| CN-1644578-A | AB type poly(p-phenyl) benzdioxan monomer and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-27 | — | — | CN | claimed |
| CN-107163250-B | A kind of preparation and application of 4,6- diamino resorcin hydrochlorate and its compound salt monomer for the modified PBO of monohydroxy | 金宁人 | 2019-09-17 | — | — | CN | disclosed |
| CN-107163250-B | A kind of preparation and application of 4,6- diamino resorcin hydrochlorate and its compound salt monomer for the modified PBO of monohydroxy | 金宁人 | 2019-09-17 | — | — | CN | disclosed |
| CN-105601646-B | 4 [6 (methyl mercapto) benzo [1,2 d:5,4 d '] two [base of 1,3] oxazoles 2] benzoic acid preparation method | 南通大学 | 2017-10-17 | — | — | CN | disclosed |
| CN-107163250-A | A kind of preparation and application for 4,6 diamino resorcin hydrochlorates and its compound salt monomer that PBO is modified for monohydroxy | 金宁人 | 2017-09-15 | — | — | CN | disclosed |
| CN-1275950-C | AB type poly(p-phenyl) benzdioxan monomer and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-09-20 | — | — | CN | disclosed |
| CN-1709858-A | 4-amino-6-nitro resorcin hydrochloride, and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-12-21 | — | — | CN | disclosed |
| CN-1709858-A | 4-amino-6-nitro resorcin hydrochloride, and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-12-21 | — | — | CN | disclosed |
| CN-1709858-A | 4-amino-6-nitro resorcin hydrochloride, and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-12-21 | — | — | CN | disclosed |
| CN-1644578-A | AB type poly(p-phenyl) benzdioxan monomer and its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-27 | — | — | CN | disclosed |