Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.45 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.44 |
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.43 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.43 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.43 |
| ▸ | ITK known ✓ | Q08881 | 1/20 | 0.43 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764271 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL11613395 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL8778695 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL12096492 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL10767578 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL2495415 | 0.96 | TP53 (0.45) | ALDH1A1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL6727933 | 0.91 | L3MBTL1 (0.47) | ALDH1A1TP53HPGDNPC1MITF | |
| SCHEMBL9752728 | 0.89 | L3MBTL1 (0.50) | TP53TSHRNPC1MITFLMNA | |
| SCHEMBL9752719 | 0.89 | L3MBTL1 (0.50) | TP53TSHRNPC1MITFLMNA | |
| SCHEMBL9752571 | 0.89 | L3MBTL1 (0.50) | TP53TSHRNPC1MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503982-B1 | CONCENTRATES FOR TREATING SUBSTRATES | COGNIS IP MAN GMBH (DE) | 2018-04-25 | — | — | EP | disclosed |
| WO-2014202150-A1 | NEW CATIONIC DYES, KITS AND COMPOSITIONS THEREOF, AND PROCESS FOR DYEING KERATIN FIBERS | ALFA PARF GROUP S.P.A. (IT) | 2014-12-24 | — | — | WO | disclosed |
| EP-1982749-B1 | Novel hair colouring compositions for use in oxidative hair dyeing | PROCTER & GAMBLE (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2503982-A2 | CONCENTRATES FOR TREATING SUBSTRATES | Cognis IP Management GmbH (DE) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063902-A2 | CONCENTRATES FOR TREATING SUBSTRATES | COGNIS IP MANAGEMENT GMBH (DE) | 2011-06-03 | — | — | WO | disclosed |
| EP-2327390-A1 | Concentrates for treating substrates | Cognis IP Management GmbH (DE) | 2011-06-01 | — | — | EP | disclosed |
| EP-1359890-A4 | PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR | P & G CLAIROL INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1353638-A4 | NOVEL COUPLERS FOR USE IN OXIDATIVE HAIR DYEING | P & G CLAIROL INC (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1353637-A4 | NOVEL COUPLERS FOR USE IN OXIDATIVE HAIR DYEING | P & G CLAIROL INC (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1982749-A2 | Novel hair colouring compositions for use in oxidative hair dyeing | The Procter and Gamble Company (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20020102224-A1 | Novel coupler for use in oxidative hair dyeing | WELLA OPERATIONS US, LLC | 2002-08-01 | — | — | US | disclosed |
| WO-2002058632-A2 | PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR | P&G-CLARIOL, INC. (US) | 2002-08-01 | — | — | WO | disclosed |
| WO-2002047635-A1 | NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING | P&G-CLAIROL, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
| WO-2002045675-A1 | PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR | P&G - CLAIROL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2002039969-A1 | NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING | P&G-CLAIROL, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| WO-2002039967-A1 | NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING | P&G - CLAIROL, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| WO-2002039970-A1 | NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING | P&G - CLAIROL, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| WO-2002039968-A1 | NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING | P&G - CLAIROL, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| US-5827503-A | ORAL APPLICATION OF ALKYLDIMETHYBENZYLAMMONIUM CHLORIDE, SODIUM CHLORIDE AND WATER BY RINSING OR MOUTHWASH OR TOOTH PASTE TO PREVENT PERIODONTITIS, GINGIVITIS, HALITOSIS, APHTHOUS ULCER OR PLAQUE FORMATION | COLLAGENEX PHARMACEUTICALS, INC. (US) | 1998-10-27 | — | — | US | disclosed |
| WO-1998005297-A1 | COMPOSITION FOR TREATING PERIODONTITIS | COLLAGENEX PHARM INC (US) | 1998-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020102224-A1 | Novel coupler for use in oxidative hair dyeing | CBR1, CBR3, PYCR1 | HSP90AA1 3923/4885CA2 1540/4885JAK2 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.