Hydrochloric Acid

Hydrochloric Acid

SCHEMBL21521915

Brc1cnc2c(c1)CNC2.Cl

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 known ✓ O60674 2/20 0.32
ABL1 known ✓ P00519 2/20 0.32
RET known ✓ P07949 2/20 0.32
FGFR1 known ✓ P11362 2/20 0.32
PDGFRA known ✓ P16234 2/20 0.32
FLT1 known ✓ P17948 2/20 0.32
KDR known ✓ P35968 2/20 0.32
ACVR1 known ✓ Q04771 2/20 0.32
ROCK1 known ✓ Q13464 2/20 0.32
ALK known ✓ Q9UM73 2/20 0.32
PRKD3 known ✓ O94806 1/20 0.32
NTRK1 known ✓ P04629 1/20 0.32
MET known ✓ P08581 1/20 0.32
PDGFRB known ✓ P09619 1/20 0.32
PRKCQ known ✓ Q04759 1/20 0.32
CSF1R known ✓ P07333 1/20 0.31
NTRK2 known ✓ Q16620 1/20 0.31
PNMT P11086 1/20 0.36
ASIC3 Q9UHC3 1/20 0.36
DYRK1A Q13627 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3871102 0.98 PNMT (0.37) PNMTASIC3DYRK1AHTTKMT2A
Hydrochloric Acid SCHEMBL31184489 0.83 PNMT (0.49) PNMTASIC3SMN1; SMN2
Hydrochloric Acid SCHEMBL30331878 0.83 PNMT (0.49) PNMTASIC3SMN1; SMN2
Hydrochloric Acid SCHEMBL2262405 0.83 PNMT (0.49) PNMTASIC3SMN1; SMN2
Hydrochloric Acid SCHEMBL16935156 0.83 PNMT (0.49) PNMTASIC3SMN1; SMN2
SCHEMBL29762650 0.81 PNMT (0.50) PNMTASIC3
SCHEMBL21591692 0.81 PNMT (0.50) PNMTASIC3
SCHEMBL722943 0.81 PNMT (0.50) PNMTASIC3SMN1; SMN2
SCHEMBL29727983 0.81 PNMT (0.50) PNMTASIC3SMN1; SMN2
SCHEMBL6217721 0.80 AURKA (0.34) PNMTASIC3DYRK1AABHD6AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250382308-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION AS (US) 2025-12-18 US disclosed
EP-4419525-B1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LTD (GB) 2025-07-23 EP disclosed
US-20250230165-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LIMITED (GB) 2025-07-17 US disclosed
EP-4511119-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS Nuevolution A/S (DK) 2025-02-26 EP disclosed
US-20250034120-A1 PYRIDAZINONES AS PARP7 INHIBITORS RIBON THERAPEUTICS, INC. 2025-01-30 US disclosed
CN-119365455-A Having a bromodomain active compounds 纽韦卢森公司 2025-01-24 CN disclosed
EP-4419525-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER Artios Pharma Limited (GB) 2024-08-28 EP disclosed
CN-118556059-A Heterocyclic compounds for the treatment of cancer 阿提奥斯医药有限公司 2024-08-27 CN disclosed
CN-112955446-B 6-Fluoro-2-methylbenzo [ D ] thiazol-5-yl compounds 伊莱利利公司 2024-07-12 CN disclosed
WO-2023205251-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION A/S (DK) 2023-10-26 WO disclosed
CN-112313228-A Novel heteroaryl heterocyclyl compounds for the treatment of autoimmune diseases 豪夫迈·罗氏有限公司 2021-02-02 CN disclosed
US-20210024502-A1 PYRIDAZINONES AS PARP7 INHIBITORS ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE 2021-01-28 US disclosed
US-10870641-B2 Pyridazinones as PARP7 inhibitors RIBON THERAPEUTICS, INC. (US) 2020-12-22 US disclosed
US-10836773-B1 6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds ELI LILLY AND COMPANY (US) 2020-11-17 US disclosed
US-10752632-B2 6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds ELI LILLY AND COMPANY (US) 2020-08-25 US disclosed
US-20200123134-A1 PYRIDAZINONES AS PARP7 INHIBITORS ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE 2020-04-23 US disclosed
WO-2020068530-A1 6-FLUORO-2-METHYLBENZO[D]THIAZOL-5-YL COMPOUNDS ELI LILLY AND COMPANY (US) 2020-04-02 WO disclosed
US-20200095254-A1 6-Fluoro-2-Methylbenzo[d]thiazol-5-yl Compounds ELI LILLY AND COMPANY 2020-03-26 US disclosed
US-10550105-B2 Pyridazinones as PARP7 inhibitors Ribon Therapeutics Inc. (US) 2020-02-04 US disclosed
US-20190330194-A1 PYRIDAZINONES AS PARP7 INHIBITORS ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE 2019-10-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10752632-B2 6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds MAPT, HTT, TFEB JAK2 948/4885ABL1 640/4885RET 838/4885
US-20210024502-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885
US-20200095254-A1 6-Fluoro-2-Methylbenzo[d]thiazol-5-yl Compounds MAPT, HTT, PSEN2 JAK2 1095/4885ABL1 888/4885RET 1205/4885
US-10550105-B2 Pyridazinones as PARP7 inhibitors PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885
US-20250034120-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885
US-10836773-B1 6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds MAPT, HTT, PSEN2 JAK2 1095/4885ABL1 888/4885RET 1205/4885
US-20190330194-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885
US-20250382308-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS BRD4, BRD3, EP300 JAK2 1214/4885ABL1 461/4885RET 3885/4885
US-10870641-B2 Pyridazinones as PARP7 inhibitors PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885
US-20250230165-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER NQO1, VHL, SDHA JAK2 1113/4885ABL1 498/4885RET 861/4885
US-20200123134-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 JAK2 2244/4885ABL1 1004/4885RET 2740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.