Hydrochloric Acid

Hydrochloric Acid

SCHEMBL2158165

CO[Si](OC)(OC)c1ccccc1CNC(C)N.Cl

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 1/20 0.36
BCHE known ✓ P06276 1/20 0.33
CASR known ✓ P41180 1/20 0.33
ALDH1A1 P00352 3/20 0.36
MAPT P10636 1/20 0.36
ATM Q13315 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
POLB P06746 2/20 0.34
KDM4E B2RXH2 2/20 0.34
MAPK1 P28482 1/20 0.34
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3653474 0.98 ATM (0.36) ALDH1A1GAAMAPTATML3MBTL1
SCHEMBL21060581 0.84 ATM (0.33) ATML3MBTL1POLBKDM4EMAPK1
SCHEMBL5619642 0.83 ATM (0.35) ALDH1A1ATML3MBTL1POLBKDM4E
SCHEMBL21060569 0.81 KDM4E (0.32) ALDH1A1ATML3MBTL1POLBKDM4E
SCHEMBL4387371 0.80 HPGD (0.32) ALDH1A1GAAMAPTHPGDHTT
Hydrochloric Acid SCHEMBL2158162 0.75 CHRM2 (0.48) MAPTPOLBBCHEKMT2AMEN1
SCHEMBL1492149 0.74 ATM (0.35) ALDH1A1GAAMAPTATML3MBTL1
SCHEMBL3653473 0.73 CHRM2 (0.49) MAPTPOLBBCHEKMT2AMEN1
SCHEMBL4844480 0.72 ALDH1A1 (0.31) ALDH1A1KDM4EMAPK1
SCHEMBL28036038 0.72 PNMT (0.45) ALDH1A1GAAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323260-B1 AMINOHYDROCARBONSILOXANE MOIETY COMPRISING BOTH SILICON AND NITROGEN. BAYER INC. (CA) 2001-11-27 US claimed
EP-1131379-A1 PROCESS FOR HYDROPHOBICIZING PARTICLES, AND THEIR USE IN DISPERSIONS Bayer Inc. (CA) 2001-09-12 EP claimed
WO-2000031178-A1 PROCESS FOR HYDROPHOBICIZING PARTICLES, AND THEIR USE IN DISPERSIONS BAYER INC. (CA) 2000-06-02 WO claimed
US-20160222201-A1 BUTYL RUBBER COMPOUNDS COMPRISING A MIXED MODIFIER SYSTEM ARLANXEO CANADA INC (CA) 2016-08-04 US disclosed
EP-2203514-B1 BUTYL RUBBER COMPOUNDS COMPRISING A THREE COMPONENT MIXED MODIFIER SYSTEM LANXESS INC (CA) 2012-09-05 EP disclosed
EP-2455422-A1 Butyl rubber compounds comprising a mixed modifier system Lanxess Inc. (CA) 2012-05-23 EP disclosed
US-8071668-B2 Butyl rubber compounds comprising a three component mixed modifier system LANXESS INC. (US) 2011-12-06 US disclosed
US-20110184087-A1 BUTYL RUBBER COMPOUNDS COMPRISING A MIXED MODIFIER SYSTEM LANXESS INC. (CA) 2011-07-28 US disclosed
US-20100298476-A1 BUTYL RUBBER COMPOUNDS COMPRISING A THREE COMPONENT MIXED MODIFIER SYSTEM LANXESS INC. (CA) 2010-11-25 US disclosed
EP-2203514-A1 BUTYL RUBBER COMPOUNDS COMPRISING A THREE COMPONENT MIXED MODIFIER SYSTEM LANXESS Inc. (CA) 2010-07-07 EP disclosed
WO-2009049413-A1 BUTYL RUBBER COMPOUNDS COMPRISING A THREE COMPONENT MIXED MODIFIER SYSTEM LANXESS INC. (CA) 2009-04-23 WO disclosed
US-6420456-B1 ACID SALTS OF AMINES AND SILANES WITH HYDROLYSIS BAYER INC. (CA) 2002-07-16 US disclosed
US-6407153-B1 Silica-containing rubber compositions BAYER INC. (CA) 2002-06-18 US disclosed
US-6323260-B1 AMINOHYDROCARBONSILOXANE MOIETY COMPRISING BOTH SILICON AND NITROGEN. BAYER INC. (CA) 2001-11-27 US disclosed
US-20010009948-A1 Elastomeric butyl compounds with improved chemical bonding between the butyl elastomer and the filler BAYER INC. (CA) 2001-07-26 US disclosed
EP-1111004-A1 Elastomeric butyl compounds with improved chemical bonding between the butyl elastomer and the filler Bayer Inc. (CA) 2001-06-27 EP disclosed
EP-1021484-A1 ELASTOMERIC COMPOSITIONS AND PROCESS FOR PRODUCTION THEREOF Bayer Inc. (CA) 2000-07-26 EP disclosed
EP-0983317-A1 PROCESS FOR HYDROPHOBICIZING PARTICLES, AND THEIR USE AS FILLERS IN POLYMER MASTERBATCHES Bayer Inc. (CA) 2000-03-08 EP disclosed
WO-1999015583-A1 ELASTOMERIC COMPOSITIONS AND PROCESS FOR PRODUCTION THEREOF BAYER INC. (CA) 1999-04-01 WO disclosed
WO-1998053004-A1 PROCESS FOR HYDROPHOBICIZING PARTICLES, AND THEIR USE AS FILLERS IN POLYMER MASTERBATCHES BAYER INC. (CA) 1998-11-26 WO disclosed