Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 2/20 | 0.62 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.62 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.53 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.53 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 known ✓ | P23458 | 1/20 | 0.47 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.44 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556152 | 0.98 | BCHE (0.64) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL24258289 | 0.91 | HRH3 (0.62) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL19650799 | 0.91 | BCHE (0.61) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL24393407 | 0.86 | BCHE (0.57) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL4208525 | 0.84 | ACHE (0.65) | BCHEACHEBACE1TEAD1KDM1A | |
| SCHEMBL21729631 | 0.84 | ACHE (0.50) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL24258285 | 0.84 | BCHE (0.50) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL23545550 | 0.82 | MAOA (0.54) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL23545657 | 0.82 | MAOA (0.54) | BCHEACHEBACE1TEAD1MEN1 | |
| SCHEMBL25253729 | 0.82 | BCHE (0.52) | BCHEACHEBACE1TEAD1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920151-B1 | METHOD FOR PRODUCING CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2017-09-27 | — | — | EP | disclosed |
| US-9656964-B2 | Method for producing carboxamides | BAYER CROPSCIENCE AG (DE) | 2017-05-23 | — | — | US | disclosed |
| US-20160009655-A1 | METHOD FOR PRODUCING CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2016-01-14 | — | — | US | disclosed |
| EP-2920151-A1 | METHOD FOR PRODUCING CARBOXAMIDES | Bayer Cropscience AG (DE) | 2015-09-23 | — | — | EP | disclosed |
| EP-2351747-B1 | Fungicide n-cycloalkyl-benzyl-amide derivatives | BAYER IP GMBH (DE) | 2014-07-02 | — | — | EP | disclosed |
| WO-2014076007-A1 | METHOD FOR PRODUCING CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2014-05-22 | — | — | WO | disclosed |
| EP-1981866-B1 | N-cyclopropyl-N-benzylamides as fungicides | BAYER CROPSCIENCE AG (DE) | 2013-02-27 | — | — | EP | disclosed |
| CN-101360730-B | Fungicide N-cycloalkyl-benzyl-amide derivatives | BAYER CROPSCIENCE SA | 2012-06-27 | — | — | CN | disclosed |
| US-8088927-B2 | Fungicide N-cycloalkyl-benzyl-amide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-01-03 | — | — | US | disclosed |
| EP-2351747-A1 | Fungicide n-cycloalkyl-benzyl-amide derivatives | Bayer CropScience AG (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100286221-A1 | Fungicide N-Cycloalkyl-Benzyl-Amide Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-11-11 | — | — | US | disclosed |
| CN-101360730-A | Fungicide N-cycloalkyl-benzyl-amide derivatives | BAYER CROPSCIENCE SA (FR) | 2009-02-04 | — | — | CN | disclosed |
| EP-1981866-A1 | FUNGICIDE N-CYCLOALKYL-BENZYL-AMIDE DERIVATIVES | Bayer CropScience S.A. (FR) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007087906-A1 | FUNGICIDE N-CYCLOALKYL-BENZYL-AMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009655-A1 | METHOD FOR PRODUCING CARBOXAMIDES | CBR3, NQO2, CPS1 | BCHE 450/4885ACHE 2576/4885MAOA 1395/4885 |
| US-20100286221-A1 | Fungicide N-Cycloalkyl-Benzyl-Amide Derivatives | CYP51A1, CBR3, ERG28 | BCHE 81/4885ACHE 1038/4885MAOA 677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.