Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.42 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.42 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473779 | 0.98 | ADRA2B (0.47) | ADRA2BMAOAMAOBAPPEGFR | |
| Hydrochloric Acid SCHEMBL6269529 | 0.90 | EGFR (0.53) | ADRA2BAPPEGFRMAPTBLM | |
| Hydrochloric Acid SCHEMBL6849297 | 0.90 | MAPT (0.46) | ADRA2BMAOAMAOBMAPTBLM | |
| Hydrochloric Acid SCHEMBL6856018 | 0.90 | MEN1 (0.46) | ADRA2BMAPTMEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL6273889 | 0.89 | ADRA2B (0.44) | ADRA2BMAOAMAOBMAPTMEN1 | |
| SCHEMBL6270346 | 0.87 | ADRA2B (0.50) | ADRA2BMAOAMAOBAPPEGFR | |
| SCHEMBL6267226 | 0.87 | MAPT (0.47) | ADRA2BMAOAMAOBMAPTBLM | |
| SCHEMBL6272111 | 0.87 | MEN1 (0.47) | ADRA2BMAPTMEN1KMT2APOLB | |
| SCHEMBL6741722 | 0.87 | ADRA2B (0.43) | ADRA2BMAOAMAOBAPPEGFR | |
| SCHEMBL6269373 | 0.87 | MEN1 (0.43) | ADRA2BMAOAMAOBEGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558204-B1 | MEANS FOR COLOURING KERATIN FIBRES COMPRISING 2-AMINO-5-ETHYLPHENOL | Wella GmbH (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-7641702-B2 | O-Aminophenol derivatives and colorants containing said compounds | WELLA AG (DE) | 2010-01-05 | — | — | US | disclosed |
| US-20080235882-A1 | Novel O-Aminophenol Derivatives and Colorants Containing Said Compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2008-10-02 | — | — | US | disclosed |
| EP-1926469-A1 | AGENT TO COLOR KERATIN FIBERS CONTAINING 2-AMINO-5-METHYLPHENOL AND M-AMINOPHENOLES | The Procter and Gamble Company (US) | 2008-06-04 | — | — | EP | disclosed |
| CN-101044112-A | O-aminophenol derivatives and colorants containing these compounds | PROCTER & GAMBLE (US) | 2007-09-26 | — | — | CN | disclosed |
| US-20070099959-A1 | O-Aminophenol derivatives and colorants containing these compounds | THE PROCTER & GAMBLE COMPANY (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070067926-A1 | Agent for dyeing keratin fibers containing 2-amino-5-methyl-phenol and m-aminophenoles | PROCTER & GAMBLE COMPANY, THE | 2007-03-29 | — | — | US | disclosed |
| WO-2007034410-A1 | AGENT TO COLOR KERATIN FIBERS CONTAINING 2-AMINO-5-METHYLPHENOL AND M-AMINOPHENOLES | THE PROCTER & GAMBLE COMPANY (US) | 2007-03-29 | — | — | WO | disclosed |
| US-20070017040-A1 | 2-Amino-5-aminomethyl-phenol derivatives and agent for coloring keratin fibers comprising these derivatives | PROCTER & GAMBLE COMPANY, THE | 2007-01-25 | — | — | US | disclosed |
| EP-1746088-A1 | 2-Amino-5-aminomethyl-phenol derivatives and agent for coloring keratin fibers comprising these derivatives | Wella Aktiengesellschaft (DE) | 2007-01-24 | — | — | EP | disclosed |
| US-6800097-B2 | FOR DYEING KERATIN FIBERS; HAIR DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2004-10-05 | — | — | US | disclosed |
| US-6780998-B2 | DEVELOPER-COUPLER SUBSTANCE COMBINATION HAIR DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2004-08-24 | — | — | US | disclosed |
| US-6685751-B2 | SUCH AS 2-((2-AMINO-PHENYLAMINO)-METHYL)-1,4-DIAMINOBENZENE; HAIR DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2004-02-03 | — | — | US | disclosed |
| US-6602302-B1 | Mixtures of carbocyclic amines such as 2-((2-aminophenylamino) -methyl)-1,4-diaminobenzene, couplers and developers, having photostability, wash and colorfastness, used for dyeing human hair | WELLA AG (DE) | 2003-08-05 | — | — | US | disclosed |
| US-20030110578-A1 | Substituted 1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2003-06-19 | — | — | US | disclosed |
| US-20030070241-A1 | Substituted 2-aminoalkyl-1,4-Diaminobenzene compounds and oxidation dye precursor compositions containing same | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2003-04-17 | — | — | US | disclosed |
| US-20020189033-A1 | Substituted 2-aminoalkyl-1,4diaminobenzene compounds and oxidation dye precursor compositions containing same | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2002-12-19 | — | — | US | disclosed |
| US-6436152-B1 | Substituted 2-aminoalky-1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same | WELLA AKTIENGESELLSCHAFT (DE) | 2002-08-20 | — | — | US | disclosed |
| JP-2001199942-A | NEW 1,4-DIAMINOBENZENE DERIVATIVE AND DYEING AGENT CONTAINING THE COMPOUND | WELLA AG | 2001-07-24 | — | — | JP | disclosed |
| EP-1116711-A2 | 2-aminoalkyl-1,4-diaminobenzene derivatives and dye composition containing these compounds | Wella Aktiengesellschaft (DE) | 2001-07-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099959-A1 | O-Aminophenol derivatives and colorants containing these compounds | KRT18, TYR, ALPG | ADRA2B 3020/4885MAOA 839/4885MAOB 733/4885 |
| US-20020189033-A1 | Substituted 2-aminoalkyl-1,4diaminobenzene compounds and oxidation dye precursor compositions containing same | DDT, CYP1B1, ALDH7A1 | ADRA2B 1384/4885MAOA 192/4885MAOB 128/4885 |
| US-20030070241-A1 | Substituted 2-aminoalkyl-1,4-Diaminobenzene compounds and oxidation dye precursor compositions containing same | DDT, ALDH7A1, DDC | ADRA2B 2238/4885MAOA 171/4885MAOB 161/4885 |
| US-20070017040-A1 | 2-Amino-5-aminomethyl-phenol derivatives and agent for coloring keratin fibers comprising these derivatives | KRT18, ALDH7A1, MKI67 | ADRA2B 1806/4885MAOA 1134/4885MAOB 1305/4885 |
| US-20030110578-A1 | Substituted 1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same | KRT18, AOC1, DAO | ADRA2B 2700/4885MAOA 285/4885MAOB 85/4885 |
| US-20080235882-A1 | Novel O-Aminophenol Derivatives and Colorants Containing Said Compounds | CBR3, KRT18, F12 | ADRA2B 3028/4885MAOA 1707/4885MAOB 1561/4885 |
| US-20070067926-A1 | Agent for dyeing keratin fibers containing 2-amino-5-methyl-phenol and m-aminophenoles | KRT18, H1-5, H1-4 | ADRA2B 1022/4885MAOA 1977/4885MAOB 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.