Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norvaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 5/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.52 |
| ▸ | NOS1 | P29475 | 3/20 | 0.46 |
| ▸ | GSR | P00390 | 2/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norvaline SCHEMBL2512779 | 1.00 | SLC1A2 (0.52) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL2513624 | 1.00 | SLC1A2 (0.52) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL2512780 | 1.00 | SLC1A2 (0.52) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL2517585 | 1.00 | SLC1A2 (0.52) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL2517586 | 1.00 | SLC1A2 (0.52) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL166375 | 0.94 | SLC1A2 (0.47) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL167818 | 0.91 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL197812 | 0.87 | — | — | |
| Norvaline SCHEMBL21114359 | 0.87 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL840389 | 0.87 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612370-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-12577210-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12577209-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12540119-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-02-03 | — | — | US | disclosed |
| US-12522568-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473261-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-11-18 | — | — | US | disclosed |
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-29 | — | — | US | disclosed |
| US-20250162997-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-20250163000-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-8344014-B2 | — | — | 2013-01-01 | — | — | US | disclosed |
| US-20120220643-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220642-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-8183288-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-05-22 | — | — | US | disclosed |
| US-8178572-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110313043-A1 | Amino Acid Compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-12-22 | — | — | US | disclosed |
| US-8034836-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-10-11 | — | — | US | disclosed |
| US-7777074-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090105328-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-04-23 | — | — | US | disclosed |
| US-20090076110-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473261-B2 | Amino acid compositions | ASNS, GLUL, ARGLU1 | SLC1A2 28/4885SLC1A1 24/4885SLC1A3 26/4885 |
| US-20120220643-A1 | Amino Acid Compounds | AADAT, OAT, SLC1A5 | SLC1A2 9/4885SLC1A1 15/4885SLC1A3 36/4885 |
| US-20250163000-A1 | AMINO ACID COMPOSITIONS | MUSK, MYOF, PYGM | SLC1A2 58/4885SLC1A1 64/4885SLC1A3 65/4885 |
| US-12612370-B2 | Amino acid compositions | TNNT2, NPR1, NOS2 | SLC1A2 29/4885SLC1A1 63/4885SLC1A3 46/4885 |
| US-12448357-B1 | Amino acid compositions | SLC6A15, SLC1A5, SLC6A19 | SLC1A2 14/4885SLC1A1 12/4885SLC1A3 16/4885 |
| US-12540119-B2 | Amino acid compositions | NOS2, NOS1, NOS3 | SLC1A2 28/4885SLC1A1 38/4885SLC1A3 30/4885 |
| US-20090076110-A1 | Amino Acid Compounds | OAT, ARGLU1, ASNS | SLC1A2 72/4885SLC1A1 81/4885SLC1A3 89/4885 |
| US-12577209-B2 | Amino acid compositions | ARG1, NOS1, NOS2 | SLC1A2 24/4885SLC1A1 28/4885SLC1A3 26/4885 |
| US-20090105328-A1 | Amino Acid Compounds | DNPEP, AADAT, ASNS | SLC1A2 20/4885SLC1A1 23/4885SLC1A3 32/4885 |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | SLC1A2 30/4885SLC1A1 27/4885SLC1A3 29/4885 |
| US-12577210-B2 | Amino acid compositions | NPR1, SLC1A5, SLC6A15 | SLC1A2 18/4885SLC1A1 21/4885SLC1A3 16/4885 |
| US-20110313043-A1 | Amino Acid Compositions | ARGLU1, AADAT, MUSK | SLC1A2 41/4885SLC1A1 48/4885SLC1A3 60/4885 |
| US-20250162997-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | SLC1A2 28/4885SLC1A1 24/4885SLC1A3 26/4885 |
| US-20120220642-A1 | Amino Acid Compounds | AADAT, SLC10A2, SLC6A12 | SLC1A2 20/4885SLC1A1 22/4885SLC1A3 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.