Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.82 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL2516105 | 1.00 | CYP3A4 (0.82) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL2511227 | 1.00 | CYP3A4 (0.82) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL137600 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL30852263 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL28071764 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL3260 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL388560 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL19974306 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| D-Histidine SCHEMBL288043 | 0.91 | CYP3A4 (1.00) | CYP3A4SLC7A5CPB2HRH4HRH3 | |
| Histidine SCHEMBL23002334 | 0.89 | CYP3A4 (0.97) | CYP3A4SLC7A5CPB2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612370-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-12577210-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12577209-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12540119-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-02-03 | — | — | US | disclosed |
| US-12522568-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473261-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-11-18 | — | — | US | disclosed |
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-29 | — | — | US | disclosed |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-20250162999-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-8344014-B2 | — | — | 2013-01-01 | — | — | US | disclosed |
| US-20120220643-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220642-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-8183288-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-05-22 | — | — | US | disclosed |
| US-8178572-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110313043-A1 | Amino Acid Compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-12-22 | — | — | US | disclosed |
| US-8034836-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-10-11 | — | — | US | disclosed |
| US-7777074-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090105328-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-04-23 | — | — | US | disclosed |
| US-20090076110-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473261-B2 | Amino acid compositions | ASNS, GLUL, ARGLU1 | CYP3A4 1179/4885SLC7A5 13/4885CPB2 3159/4885 |
| US-20120220643-A1 | Amino Acid Compounds | AADAT, OAT, SLC1A5 | CYP3A4 2273/4885SLC7A5 8/4885CPB2 1035/4885 |
| US-12612370-B2 | Amino acid compositions | TNNT2, NPR1, NOS2 | CYP3A4 1657/4885SLC7A5 51/4885CPB2 1556/4885 |
| US-12448357-B1 | Amino acid compositions | SLC6A15, SLC1A5, SLC6A19 | CYP3A4 635/4885SLC7A5 13/4885CPB2 741/4885 |
| US-12540119-B2 | Amino acid compositions | NOS2, NOS1, NOS3 | CYP3A4 1293/4885SLC7A5 26/4885CPB2 3493/4885 |
| US-20090076110-A1 | Amino Acid Compounds | OAT, ARGLU1, ASNS | CYP3A4 760/4885SLC7A5 46/4885CPB2 2849/4885 |
| US-12577209-B2 | Amino acid compositions | ARG1, NOS1, NOS2 | CYP3A4 1377/4885SLC7A5 27/4885CPB2 2064/4885 |
| US-20090105328-A1 | Amino Acid Compounds | DNPEP, AADAT, ASNS | CYP3A4 2870/4885SLC7A5 27/4885CPB2 829/4885 |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | CYP3A4 1266/4885SLC7A5 14/4885CPB2 3097/4885 |
| US-12577210-B2 | Amino acid compositions | NPR1, SLC1A5, SLC6A15 | CYP3A4 1575/4885SLC7A5 14/4885CPB2 3113/4885 |
| US-20250162999-A1 | AMINO ACID COMPOSITIONS | ASNS, SLC1A5, BCAT2 | CYP3A4 2232/4885SLC7A5 8/4885CPB2 2911/4885 |
| US-20110313043-A1 | Amino Acid Compositions | ARGLU1, AADAT, MUSK | CYP3A4 1704/4885SLC7A5 31/4885CPB2 1722/4885 |
| US-20120220642-A1 | Amino Acid Compounds | AADAT, SLC10A2, SLC6A12 | CYP3A4 809/4885SLC7A5 9/4885CPB2 629/4885 |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | CYP3A4 1179/4885SLC7A5 13/4885CPB2 3159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.