Hydrochloric Acid

Hydrochloric Acid

SCHEMBL2551834

CC12CC3CC(C1)CC(N)(C3)C2.Cl

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN1 known ✓ Q05586 7/20 0.64
GRIN2A known ✓ Q12879 7/20 0.64
GRIN2D known ✓ O15399 6/20 0.60
GRIN3B known ✓ O60391 6/20 0.60
GRIN2B known ✓ Q13224 6/20 0.60
GRIN2C known ✓ Q14957 6/20 0.60
GRIN3A known ✓ Q8TCU5 6/20 0.60
ESR1 known ✓ P03372 1/20 0.60
ADRB3 known ✓ P13945 1/20 0.60
ACHE known ✓ P22303 1/20 0.60
OPRK1 known ✓ P41145 1/20 0.60
SIGMAR1 known ✓ Q99720 1/20 0.48
LMNA P02545 4/20 0.64
PMP22 Q01453 2/20 0.64
NPSR1 Q6W5P4 1/20 0.64
SLC22A1 O15245 2/20 0.60
NFKB1 P19838 2/20 0.60
CYP2C9 P11712 2/20 0.60
MTOR P42345 1/20 0.60
HTT P42858 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1764807 0.98 GRIN1 (0.62) GRIN1GRIN2ALMNAPMP22NPSR1
SCHEMBL25552171 0.98 GRIN1 (0.62) GRIN1GRIN2ALMNAPMP22NPSR1
Hydrochloric Acid SCHEMBL866896 0.82 LMNA (0.67) GRIN1GRIN2ALMNAPMP22NPSR1
Hydrochloric Acid SCHEMBL28669825 0.82 GRIN1 (0.50) GRIN1GRIN2ALMNAPMP22NPSR1
Hydrochloric Acid SCHEMBL1880961 0.82 LMNA (0.67) GRIN1GRIN2ALMNAPMP22NPSR1
SCHEMBL1938959 0.80 GRIN1 (0.47) GRIN1GRIN2ALMNAPMP22NPSR1
Memantine SCHEMBL249401 0.79 GRIN1 (0.86) GRIN1GRIN2ALMNAPMP22NPSR1
Memantine SCHEMBL1374768 0.79 GRIN1 (0.86) GRIN1GRIN2ALMNAPMP22NPSR1
SCHEMBL12132159 0.79 GRIN1 (0.65) GRIN1GRIN2ALMNAPMP22NPSR1
SCHEMBL733849 0.79 GRIN1 (0.48) GRIN1GRIN2ALMNAPMP22NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119936252-A Memantine hydrochloride and detection method of related substances thereof 宁夏医科大学 2025-05-06 CN claimed
EP-2555616-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE Hetero Research Foundation (IN) 2013-02-13 EP claimed
WO-2011125062-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE HETERO RESEARCH FOUNDATION (IN) 2011-10-13 WO claimed
US-20260092039-A1 DUAL INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIV BARCELONA (ES) 2026-04-02 US disclosed
EP-4676916-A1 DUAL INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE Universitat De Barcelona (ES) 2026-01-14 EP disclosed
CN-119936252-A Memantine hydrochloride and detection method of related substances thereof 宁夏医科大学 2025-05-06 CN disclosed
CN-119936252-A Memantine hydrochloride and detection method of related substances thereof 宁夏医科大学 2025-05-06 CN disclosed
WO-2024184305-A1 DUAL INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIVERSITAT DE BARCELONA (ES) 2024-09-12 WO disclosed
US-11597727-B2 Inhibitors of integrin alpha 2 beta 1 and methods of use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-07 US disclosed
CN-107334744-B Memantine hydrochloride medicine composition and preparation method thereof 湖南洞庭药业股份有限公司 2020-09-04 CN disclosed
EP-2555616-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE Hetero Research Foundation (IN) 2013-02-13 EP disclosed
EP-2555616-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE Hetero Research Foundation (IN) 2013-02-13 EP disclosed
WO-2011125062-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE HETERO RESEARCH FOUNDATION (IN) 2011-10-13 WO disclosed
WO-2011125062-A1 PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE HETERO RESEARCH FOUNDATION (IN) 2011-10-13 WO disclosed
EP-1999100-A1 PROCESS FOR PREPARING MEMANTINE HYDROCHLORIDE SUBSTANTIALLY FREE OF IMPURITIES Teva Pharmaceutical Fine Chemicals S.R.L. (IT) 2008-12-10 EP disclosed
US-20080033054-A1 Process for preparing memantine hydrochloride substantially free of impurities TEVA PHARMACEUTICALS USA, INC. 2008-02-07 US disclosed
WO-2007126886-A1 PROCESS FOR PREPARING MEMANTINE HYDROCHLORIDE SUBSTANTIALLY FREE OF IMPURITIES TEVA PHARMACEUTICALS USA, INC. (US) 2007-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11597727-B2 Inhibitors of integrin alpha 2 beta 1 and methods of use ITGB1, ITGB2, ITGA2 GRIN1 933/4885GRIN2A 918/4885GRIN2D 830/4885
US-20080033054-A1 Process for preparing memantine hydrochloride substantially free of impurities PNMT, PSEN2, CHRNA5 GRIN1 83/4885GRIN2A 16/4885GRIN2D 68/4885
US-20260092039-A1 DUAL INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE BACE2, BACE1, GLS2 GRIN1 31/4885GRIN2A 41/4885GRIN2D 63/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.