Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.35 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2222537 | 1.00 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL131316 | 0.98 | PLAU (0.46) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29373584 | 0.98 | PLAU (0.46) | PLAUCYP2A6F12NCF1NOS3 | |
| Bromide SCHEMBL299632 | 0.96 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 | |
| Ammonia Solution, Strong SCHEMBL28140044 | 0.96 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL27879304 | 0.92 | PLAU (0.41) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL4389307 | 0.89 | LMNA (0.39) | PLAUCYP2A6F12NCF1NOS3 | |
| Quinoline SCHEMBL28833127 | 0.88 | ALDH1A1 (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL23886136 | 0.81 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL22883707 | 0.79 | PLAU (0.39) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089252-A | Amphoteric polymer of betainised dialkylaminoalkyl acrylate or dialkylaminoalkyl acrylamide and cationic deriative | L'OREAL (FR) | 1992-02-18 | — | — | US | claimed |
| US-11825842-B2 | Quaternary amine formulations and uses thereof | AURORIUM HOLDINGS LLC (US) | 2023-11-28 | — | — | US | disclosed |
| WO-2023164152-A1 | MULTI-MODAL HAIR CARE COMPOSITION COMPRISING CATIONIC GUAR BLENDS AND PROCESS FOR PREPARATION THEREOF | ISP INVESTMENTS LLC (US) | 2023-08-31 | — | — | WO | disclosed |
| CN-114606791-A | Dissolved air debonding of tissue | GPCP知识产权控股有限责任公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-109154145-B | Dissolved air debonding of tissue | GPCP知识产权控股有限责任公司 | 2022-05-10 | — | — | CN | disclosed |
| US-11248346-B2 | Dissolved air de-bonding of a tissue sheet | GPCP IP HOLDINGS LLC (US) | 2022-02-15 | — | — | US | disclosed |
| US-11248345-B2 | Dissolved air de-bonding of a tissue sheet | GPCP IP HOLDINGS LLC (US) | 2022-02-15 | — | — | US | disclosed |
| US-20210140117-A1 | DISSOLVED AIR DE-BONDING OF A TISSUE SHEET | GPCP IP HOLDINGS LLC | 2021-05-13 | — | — | US | disclosed |
| CN-107427869-B | Heavy metal fixing agent for treating ash and method for treating ash using same | 栗田工业株式会社 | 2021-02-02 | — | — | CN | disclosed |
| CN-111465391-A | Compositions of epinephrine and prodrug with enhanced delivery | 阿奎斯蒂弗医疗股份有限公司 | 2020-07-28 | — | — | CN | disclosed |
| US-20030040555-A1 | Process for producing enlarged latex | ROHM AND HAAS COMPANY | 2003-02-27 | — | — | US | disclosed |
| EP-1245584-A1 | PROCESS FOR PRODUCING ENLARGED LATEX | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5148822-A | Applying a quaternary ammonium compound having an alkyl group attached to the ammonium nitrogen of nonprotein or protein material | JOHNSON PRODUCTS CO., INC. (US) | 1992-09-22 | — | — | US | disclosed |
| US-5139037-A | Amphoteric polymer of betanized dialkylaminoalkyl (meth)acrylate or (meth)acrylamide and a cationic polymer | L'OREAL (FR) | 1992-08-18 | — | — | US | disclosed |
| US-5089252-A | Amphoteric polymer of betainised dialkylaminoalkyl acrylate or dialkylaminoalkyl acrylamide and cationic deriative | L'OREAL (FR) | 1992-02-18 | — | — | US | disclosed |
| US-5060680-A | Applying alkaline straightener, rinsing, applying aqueous alkaline composition containing quaternary ammonium salt | JOHNSON PRODUCTS CO., INC. (US) | 1991-10-29 | — | — | US | disclosed |
| WO-1989002233-A1 | HAIR STRAIGHTENING METHOD AND TEXTURING STRENGTHENER COMPOSITION | JOHNSON PRODUCTS CO., INC. (US) | 1989-03-23 | — | — | WO | disclosed |
| US-4638822-A | CATIONIC AND ANIONIC POLYMERS | L'OREAL (FR) | 1987-01-27 | — | — | US | disclosed |
| US-RE31126-E | Quaternary ammonium compounds in pretreatment of hair before shampooing with an anionic shampoo | ALBERTO-CULVER COMPANY (US) | 1983-01-18 | — | — | US | disclosed |
| US-4061150-A | Quaternary ammonium compounds in pretreatment of hair before shampooing with an anionic shampoo | ALBERTO-CULVER COMPANY (US) | 1977-12-06 | — | — | US | disclosed |