Clortermine

Clortermine

SCHEMBL266778

CC(C)(N)Cc1ccccc1Cl.Cl

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Clortermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 3/20 0.48
SLC6A4 known ✓ P31645 2/20 0.45
SLC6A3 known ✓ Q01959 2/20 0.45
HTR2A known ✓ P28223 1/20 0.45
HRH1 known ✓ P35367 1/20 0.45
HTR2B known ✓ P41595 1/20 0.45
KCNH2 known ✓ Q12809 1/20 0.40
DPP4 known ✓ P27487 1/20 0.39
PNMT P11086 1/20 0.50
IDO1 P14902 4/20 0.48
TAAR1 Q96RJ0 5/20 0.48
CHRNA4 P43681 1/20 0.45
AOC3 Q16853 1/20 0.44
PKM P14618 1/20 0.42
LMNA P02545 1/20 0.42
HTT P42858 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clortermine SCHEMBL30791298 1.00 PNMT (0.50) PNMTIDO1TAAR1SLC6A2SLC6A4
Clortermine SCHEMBL164137 0.98 PNMT (0.52) PNMTIDO1TAAR1SLC6A2SLC6A4
Clortermine SCHEMBL30295323 0.98 PNMT (0.52) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL30818122 0.82 PNMT (0.57) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL14018901 0.82 IDO1 (0.48) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL14040511 0.82 IDO1 (0.48) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL6863939 0.82 PNMT (0.57) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL73408 0.80 IDO1 (0.50) PNMTIDO1TAAR1SLC6A2SLC6A4
Hydrochloric Acid SCHEMBL9276212 0.79 PNMT (0.50) PNMTIDO1TAAR1SLC6A2SLC6A4
SCHEMBL8976005 0.79 PNMT (0.45) PNMTIDO1TAAR1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2626 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-4749952-A2 ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM Dexcom, Inc. (US) 2026-05-27 EP disclosed
US-12629045-B2 Non-invasive analyte sensor device KNOW LABS, INC. (US) 2026-05-19 US disclosed
US-12629066-B2 Use of sensor redundancy to detect sensor failures DEXCOM, INC. (US) 2026-05-19 US disclosed
US-20260130590-A1 PROXIMITY PAIRING AND SECURITY OF A CONTINUOUS ANALYTE SENSOR SYSTEM DEXCOM INC (US) 2026-05-14 US disclosed
EP-4740859-A2 SYSTEMS AND METHOD FOR ACTIVATING ANALYTE SENSOR ELECTRONICS DexCom, Inc. (US) 2026-05-13 EP disclosed
EP-4740858-A2 PROXIMITY PAIRING AND SECURITY OF A CONTINUOUS ANALYTE SENSOR SYSTEM DexCom, Inc. (US) 2026-05-13 EP disclosed
EP-3435867-B1 SYSTEMS, DEVICES AND METHODS FOR ANALYTE MONITORING SYSTEM DEXCOM INC (US) 2026-05-13 EP disclosed
WO-1999030690-A1 ORAL DELIVERY FORMULATION AXIA THERAPEUTICS, INC. (US) 1999-06-24 WO disclosed
EP-0909183-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES Neuromedica, Inc. (US) 1999-04-21 EP disclosed
US-5795909-A ANTICARCINOGENIC AND ANTITUMOR AGENTS; BREAST, COLON, OVARIANCANCERS NEUROMEDICA, INC. (US) 1998-08-18 US disclosed
WO-1997044063-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES NEUROMEDICA, INC. (US) 1997-11-27 WO disclosed
US-5658955-A Combined use of dopamine and serotonin agonists in the treatment of immune disorders HITZIG PIETR (US) 1997-08-19 US disclosed
EP-0710106-A1 METHOD OF TREATING ADDICTIVE BEHAVIORS HITZIG, Pietr (US) 1996-05-08 EP disclosed
US-5502080-A Combined use of dopamine and serotonin agonists in the treatment of allergic disorders HITZIG PIETR (US) 1996-03-26 US disclosed
WO-1994021244-A1 METHOD OF TREATING ADDICTIVE BEHAVIORS HITZIG PIETR (US) 1994-09-29 WO disclosed