Tricyclamol

Tricyclamol

SCHEMBL2734572

C[N+]1(CCC(O)(c2ccccc2)C2CCCCC2)CCCC1.Cl

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Tricyclamol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 10/20 0.56
CHRM1 known ✓ P11229 8/20 0.56
CHRM3 known ✓ P20309 6/20 0.56
CHRM4 known ✓ P08173 5/20 0.56
CHRM5 known ✓ P08912 5/20 0.56
KCNH2 known ✓ Q12809 4/20 0.56
GRIN2D known ✓ O15399 1/20 0.54
GRIN3B known ✓ O60391 1/20 0.54
HRH1 known ✓ P35367 1/20 0.54
GRIN1 known ✓ Q05586 1/20 0.54
GRIN2A known ✓ Q12879 1/20 0.54
GRIN2B known ✓ Q13224 1/20 0.54
GRIN2C known ✓ Q14957 1/20 0.54
GRIN3A known ✓ Q8TCU5 1/20 0.54
HTR1A known ✓ P08908 1/20 0.54
OPRM1 known ✓ P35372 1/20 0.54
SIGMAR1 known ✓ Q99720 1/20 0.54
CYP2D6 P10635 4/20 0.56
MAPT P10636 1/20 0.56
BLM P54132 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tricyclamol SCHEMBL30573196 0.99 CHRM2 (0.58) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL20045514 0.81 CHRM2 (0.71) CHRM2CHRM1CHRM3CHRM4CHRM5
Iodide SCHEMBL29558329 0.77 CHRM2 (0.83) CHRM2CHRM1CHRM3CHRM4CHRM5
Hydrochloric Acid SCHEMBL7429698 0.76 CHRM2 (0.60) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL9910958 0.76 CHRM2 (0.68) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL10392382 0.75 CHRM2 (0.64) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL10516359 0.75 CHRM2 (0.64) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL2933098 0.75 CHRM2 (0.66) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL12441787 0.75 CHRM2 (0.66) CHRM2CHRM1CHRM3CHRM4CHRM5
SCHEMBL9782807 0.74 CHRM2 (0.62) CHRM2CHRM1CHRM3CHRM4CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4088717-A1 USE AND COMPOSITION FOR TREATING DEMENTIA Chase Pharmaceuticals Corporation (US) 2022-11-16 EP disclosed
EP-4035668-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS Chase Pharmaceuticals Corporation (US) 2022-08-03 EP disclosed
US-20210128528-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2021-05-06 US disclosed
US-20190314354-A1 MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM CHASE PHARMACEUTICALS CORPORATION (US) 2019-10-17 US disclosed
US-10307409-B2 Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system CHASE PHARMACEUTICALS CORPORATION (US) 2019-06-04 US disclosed
US-20190091214-A1 USE AND COMPOSITION FOR TREATING DEMENTIA CHASE PHARMACEUTICALS CORP (US) 2019-03-28 US disclosed
WO-2019033068-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2019-02-14 WO disclosed
US-20190046506-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2019-02-14 US disclosed
US-20190000826-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS CHASE PHARMACEUTICALS CORPORATION (US) 2019-01-03 US disclosed
US-20180360845-A1 MUSCARINIC COMBINATION OF A SELECTIVE M2-ANTAGONIST AND A PERIPHERAL NON-SELECTIVE ANTAGONIST FOR TREATING HYPOCHOLINERGIC DISORDERS CHASE PHARMACEUTICALS CORPORATION (US) 2018-12-20 US disclosed
CN-1113640-C Oral delivery of discrete units ALZA CORP (US) 2003-07-09 CN disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
CN-1265030-A Osmotic delivery system flow modulator appts. ALZA CORP (US) 2000-08-30 CN disclosed
CN-1265031-A Osmotic delivery system with semipermeable plug ALZA CORP (US) 2000-08-30 CN disclosed
CN-1240346-A Injectable depot gel composition and method of preparing the composition ALZA CORP (US) 2000-01-05 CN disclosed
CN-1191476-A Oral delivery of discrete units ALZA CORP (US) 1998-08-26 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190314354-A1 MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM CHRM3, CHRM2, CHRM4 CHRM2 2/4885CHRM1 5/4885CHRM3 1/4885
US-10307409-B2 Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system CHRM3, CHRM2, CHRM4 CHRM2 2/4885CHRM1 5/4885CHRM3 1/4885
US-20180360845-A1 MUSCARINIC COMBINATION OF A SELECTIVE M2-ANTAGONIST AND A PERIPHERAL NON-SELECTIVE ANTAGONIST FOR TREATING HYPOCHOLINERGIC DISORDERS CHRM2, CHRM1, CHRM4 CHRM2 1/4885CHRM1 2/4885CHRM3 5/4885
US-20190000826-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS ACHE, CHRNA5, SNCA CHRM2 46/4885CHRM1 60/4885CHRM3 32/4885
US-20190091214-A1 USE AND COMPOSITION FOR TREATING DEMENTIA ACHE, BCHE, CHAT CHRM2 11/4885CHRM1 25/4885CHRM3 18/4885
US-20210128528-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS HTR2A, HTR1A, HTR3B CHRM2 251/4885CHRM1 369/4885CHRM3 299/4885
US-20190046506-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS HTR2A, HTR1A, HTR3B CHRM2 251/4885CHRM1 369/4885CHRM3 299/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 CHRM2 4525/4885CHRM1 4583/4885CHRM3 4193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.