Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27490899 | 0.94 | DNM1 (0.41) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL227335 | 0.94 | DNM1 (0.45) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Bromide SCHEMBL10386791 | 0.90 | DNM1 (0.48) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL27823790 | 0.90 | DNM1 (0.43) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| SCHEMBL29531465 | 0.90 | DNM1 (0.47) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL27990427 | 0.88 | DNM1 (0.50) | DNM1OPRM1TSHRLMNA | |
| Hydrochloric Acid SCHEMBL6703153 | 0.88 | DNM1 (0.55) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Fluoride SCHEMBL28319638 | 0.88 | DNM1 (0.41) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Ammonia Solution, Strong SCHEMBL27583907 | 0.88 | TSHR (0.43) | DNM1OPRM1TSHRALDH1A1TDP1 | |
| Bromide SCHEMBL27829696 | 0.88 | DNM1 (0.46) | DNM1OPRM1TSHRALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104159929-A | Supported composite metallocene catalyst, method for preparing the same, and method for preparing polyolefin using the same | SK INNOVATION CO LTD | 2014-11-19 | — | — | CN | claimed |
| CN-104069737-A | Recycling and purifying method of ammonia-containing industrial waste gas | CHENGDU ORGANIC CHEMICALS CO | 2014-10-01 | — | — | CN | claimed |
| CN-104078239-A | Polymerization solution for solid electrolytic capacitor to manufacture solid electrolyte layer | FUJIAN GUOGUANG ELECTRONIC SCIENCE & TECHNOLOGY CO LTD | 2014-10-01 | — | — | CN | claimed |
| CN-103553905-A | Unsaturated alicyclic carboxylic acid and preparation method and application thereof | UNIV CENTRAL SOUTH | 2014-02-05 | — | — | CN | claimed |
| CN-101462992-B | Method for manufacturing thiodiglycolic dialkyl esters | SALTIGO GMBH | 2013-11-06 | — | — | CN | claimed |
| CN-103319483-A | Preparation method of important intermediate of linagliptin | 2Y CHEM LTD | 2013-09-25 | — | — | CN | claimed |
| CN-102084301-B | coating composition and pattern forming method | NISSAN CHEMICAL IND LTD | 2013-08-28 | — | — | CN | claimed |
| CN-103130727-A | Preparation method of saflufenacil intermediate | JIANGSU AGROCHEM LAB CO LTD | 2013-06-05 | — | — | CN | claimed |
| CN-101967000-B | Method for preparing high-solid-content and low-viscosity suspended nano calcium carbonate slurry | SHANDONG HAIZE NANOMATERIALS CO LTD | 2013-04-24 | — | — | CN | claimed |
| CN-102491959-A | Preparation method of oxirane derivative | JIANGSU CHENGYANG CROP TECHNOLOGY CO LTD | 2012-06-13 | — | — | CN | claimed |
| CN-101967000-A | Method for preparing high-solid-content and low-viscosity suspended nano calcium carbonate slurry and re-suspended nano calcium carbonate power | SHANDONG HAIZE NANOMATERIALS CO LTD | 2011-02-09 | — | — | CN | claimed |
| CN-101941911-A | Environment-friendly synthesis method for cinacalcet | SHANGHAI INST TECHNOLOGY | 2011-01-12 | — | — | CN | claimed |
| CN-101723823-A | Gemfibrozil composite method | SHANGHAI ECUST BIOMEDICINE CO | 2010-06-09 | — | — | CN | claimed |
| CN-101648711-A | Production method of cation-hybridization nano silicon sol | NANTONG HUARUN NEW MATERIAL CO | 2010-02-17 | — | — | CN | claimed |
| CN-101462992-A | Method for manufacturing thiodiglycolic dialkyl esters | SALTIGO GMBH (DE) | 2009-06-24 | — | — | CN | claimed |
| CN-101410374-A | Improved synthesis and preparation of intermediates and novel polymorphs thereof for the preparation of donepezil hydrochloride | MEDICHEM SA (ES) | 2009-04-15 | — | — | CN | claimed |
| CN-100391860-C | Method of biological inhibition using sea water cooling system | WUHAN XINHUA SCI & TECH CO LTD (CN) | 2008-06-04 | — | — | CN | claimed |
| CN-101039917-A | Process for preparing telmisartan | TEVA PHARMA (IL) | 2007-09-19 | — | — | CN | claimed |
| CN-1903740-A | Method of biological inhibition using sea water cooling system | WUHAN XINHUA SCI & TECH CO LTD (CN) | 2007-01-31 | — | — | CN | claimed |
| CN-1427743-A | Dosage forms of polymeric carriers, their use in organic chemical synthesis and process for producing said dosage forms | LONDBERK AS H (DK) | 2003-07-02 | — | — | CN | claimed |