Hydrochloric Acid

Hydrochloric Acid

SCHEMBL27714679

Cl.NC(=O)Nc1ccncc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 2/20 0.52
JAK2 known ✓ O60674 1/20 0.52
BCHE known ✓ P06276 1/20 0.50
PRKCI known ✓ P41743 1/20 0.50
ROCK2 known ✓ O75116 1/20 0.49
ROCK1 known ✓ Q13464 1/20 0.49
MDM2 Q00987 1/20 0.64
KDM4E B2RXH2 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
PEPD P12955 1/20 0.56
TAAR1 Q96RJ0 2/20 0.55
NPC1 O15118 1/20 0.54
ALDH1A1 P00352 1/20 0.54
KMT2A Q03164 3/20 0.52
MEN1 O00255 2/20 0.52
TYK2 P29597 1/20 0.52
MAPT P10636 1/20 0.50
GFER P55789 1/20 0.50
KIF11 P52732 1/20 0.48
NT5E P21589 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL230957 0.98 MDM2 (0.67) MDM2KDM4EL3MBTL1PEPDTAAR1
SCHEMBL28974307 0.90 MAPT (0.66) MDM2KDM4EL3MBTL1PEPDTAAR1
SCHEMBL4630961 0.85 KIF11 (0.63) MDM2PEPDNPC1ALDH1A1GAA
Hydrochloric Acid SCHEMBL28051056 0.83 MDM2 (0.59) MDM2KDM4EL3MBTL1TAAR1GAA
Phenylurea SCHEMBL27723303 0.81 GAA (0.66) MDM2PEPDTAAR1NPC1ALDH1A1
SCHEMBL5008975 0.81 HSD17B10 (0.58) PEPDNPC1ALDH1A1
Carbamic Acid SCHEMBL28283812 0.80 MDM2 (0.61) MDM2KDM4EL3MBTL1TAAR1GAA
SCHEMBL3188667 0.80 MDM2 (0.61) MDM2KDM4EL3MBTL1TAAR1GAA
SCHEMBL5062623 0.80 PEPD (0.80) PEPDNPC1ALDH1A1GAAKMT2A
Hydrochloric Acid SCHEMBL28030454 0.78 CTSD (0.52) MDM2KDM4EL3MBTL1TAAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116761883-A Compositions and methods for the oncolytic treatment of armed Senicaviruses 塞内卡治疗公司 2023-09-15 CN disclosed
CN-115038456-A Second generation seneca valley virus oncolytic therapy: compositions and methods thereof 纽约市哥伦比亚大学托管会 2022-09-09 CN disclosed
CN-101107249-B purine derivatives as A2A receptor agonists NOVARTIS AG 2010-10-13 CN disclosed
CN-101107249-A Purine derivatives as A2A receptor agonists NOVARTIS AG (CH) 2008-01-16 CN disclosed