Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28000315 | 1.00 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1459186 | 0.98 | NPC1 (0.36) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Iodide SCHEMBL2186162 | 0.97 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Iodide SCHEMBL299417 | 0.97 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL299882 | 0.97 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL2188209 | 0.97 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| N,N-Dimethylethanaminium SCHEMBL7062326 | 0.84 | NPC1 (0.39) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Trimethylammonium SCHEMBL869520 | 0.84 | NPC1 (0.41) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Trimethylammonium SCHEMBL635942 | 0.84 | NPC1 (0.41) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| N,N-Dimethylethanaminium SCHEMBL446053 | 0.83 | NPC1 (0.40) | NPC1GAAMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10036239-B2 | Graphene enhanced polymer composites and methods thereof | HALLIBURTON ENERGY SERVICES, INC. (US) | 2018-07-31 | — | — | US | claimed |
| US-9598631-B2 | Sulfonated relative permeability modifiers for reducing subterranean formation water permeability | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-03-21 | — | — | US | claimed |
| US-20170002262-A1 | SULFONATED RELATIVE PERMEABILITY MODIFIERS FOR REDUCING SUBTERRANEAN FORMATION WATER PERMEABILITY | HALIBURTON ENERGY SERVICES, INC. (US) | 2017-01-05 | — | — | US | claimed |
| US-20160340570-A1 | GRAPHENE ENHANCED POLYMER COMPOSITES AND METHODS THEREOF | HALLIBURTON ENERGY SERVICES INC. | 2016-11-24 | — | — | US | claimed |
| EP-2009076-A1 | Method for stimulating hydrocarbon production and reducing the production of water from a subterranean formation | Halliburton Energy Services, Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| US-7182136-B2 | Methods of reducing water permeability for acidizing a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2007-02-27 | — | — | US | claimed |
| US-20070012444-A1 | Apparatus and method for reducing water production from a hydrocarbon producing well | HALLIBURTON ENERGY SERVICES, INC. | 2007-01-18 | — | — | US | claimed |
| US-7114568-B2 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1644458-A1 | METHOD FOR STIMULATING HYDROCARBON PRODUCTION AND REDUCING THE PRODUCTION OF WATER FROM A SUBTERRANEAN FORMATION | Halliburton Energy Services, Inc. (US) | 2006-04-12 | — | — | EP | claimed |
| US-20050230114-A1 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. | 2005-10-20 | — | — | US | claimed |
| US-20050178549-A1 | Methods of reducing the permeabilities of horizontal well bore sections | HALLIBURTON ENERGY SERVICES, INC. | 2005-08-18 | — | — | US | claimed |
| WO-2005003515-A1 | METHODS OF REDUCING WATER PERMEABILITY FOR ACIDIZING A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| US-20050000694-A1 | Methods of reducing water permeability for acidizing a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004101706-A1 | METHOD FOR STIMULATING HYDROCARBON PRODUCTION AND REDUCING THE PRODUCTION OF WATER FROM A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2004-11-25 | — | — | WO | claimed |
| US-20040229756-A1 | Method for stimulating hydrocarbon production and reducing the production of water from a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-18 | — | — | US | claimed |
| US-6476169-B1 | Methods of reducing subterranean formation water permeability | HALLIBURTON ENERGY SERVICES, INC. | 2002-11-05 | — | — | US | claimed |
| EP-1193365-A1 | Reducing subterranean formation water permeability | Halliburton Energy Services, Inc. (US) | 2002-04-03 | — | — | EP | claimed |
| US-20230416598-A1 | ACIDIZING COMPOSITIONS FOR IMPROVED FLUID PERFORMANCE | HALLIBURTON ENERGY SERVICES, INC. (US) | 2023-12-28 | — | — | US | disclosed |
| US-20040229756-A1 | Method for stimulating hydrocarbon production and reducing the production of water from a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-18 | — | — | US | disclosed |
| EP-1193365-A1 | Reducing subterranean formation water permeability | Halliburton Energy Services, Inc. (US) | 2002-04-03 | — | — | EP | disclosed |