Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dinitrophenylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.67 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.64 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.61 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 6/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CES2 | O00748 | 1/20 | 0.68 |
| ▸ | CES1 | P23141 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinitrophenylene SCHEMBL28101551 | 1.00 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL29143070 | 1.00 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL29291896 | 0.97 | TSHR (1.00) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL36632 | 0.97 | TSHR (1.00) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL9733868 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL9733861 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL30600045 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL29834109 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL11661349 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 | |
| Dinitrophenylene SCHEMBL28186803 | 0.94 | TSHR (0.94) | TSHRLMNACES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118270738-A | Method for producing sulfur black and sodium thiosulfate from 2, 4-dinitrobenzene chloride | 宁夏朗利新材料股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-117024282-A | Preparation method of nitroaniline | 宁夏中盛新科技有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-112499872-B | Conditioner and treatment method of 2, 4-dinitrochlorobenzene waste acid | 浙江鸿盛化工有限公司 | 2022-11-11 | — | — | CN | claimed |
| CN-111100475-B | Preparation method of sulfur dye | 山西临汾染化(集团)有限责任公司 | 2022-02-18 | — | — | CN | claimed |
| CN-113354541-A | Method for cleanly producing 2, 4-dinitro benzene chloride | 天津泰研科技发展有限公司 | 2021-09-07 | — | — | CN | claimed |
| CN-112499872-A | Conditioner and treatment method of 2, 4-dinitrochlorobenzene waste acid | 浙江鸿盛化工有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-110627649-B | Preparation method of 2, 4-dinitroaniline | 浙江汇翔化学工业有限公司 | 2020-08-18 | — | — | CN | claimed |
| CN-110627649-A | Preparation method of 2, 4-dinitroaniline | 浙江汇翔化学工业有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-223263719-U | 2, 4-Dinitrobenzene chloride purification device | 新绛县德鑫化工有限公司 | 2025-08-26 | — | — | CN | disclosed |
| CN-223197626-U | 2, 4-Dinitrobenzene chloride washing cyclic utilization device | 新绛县德鑫化工有限公司 | 2025-08-08 | — | — | CN | disclosed |
| EP-4516778-A1 | COMPOUND SERVING AS DDR1 KINASE INHIBITOR, AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2025-03-05 | — | — | EP | disclosed |
| CN-115594629-B | Carbazole derivative with AEE characteristic and preparation method and application thereof | 辽宁师范大学 | 2024-10-11 | — | — | CN | disclosed |
| CN-118724793-A | High-efficient H that detects2S carbazole fluorescent probe and synthesis method and application thereof | 四川轻化工大学 | 2024-10-01 | — | — | CN | disclosed |
| CN-118270738-A | Method for producing sulfur black and sodium thiosulfate from 2, 4-dinitrobenzene chloride | 宁夏朗利新材料股份有限公司 | 2024-07-02 | — | — | CN | disclosed |
| US-8895805-B2 | Method for modifying insect resistance of plants by utilizing RNAi technique | SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES (CN) | 2014-11-25 | — | — | US | disclosed |
| CN-103154808-A | Liquid crystal aligning agent, liquid crystal alignment film, and liquid crystal display element using same | NISSAN CHEMICAL IND LTD | 2013-06-12 | — | — | CN | disclosed |
| US-20100181535-A1 | THE PHOTOSTABILITY AND/OR CONTROL OF THE FLUORESCENCE INTENSITY OF FLUORESCENT DYES | PICOQUANT GMBH (DE) | 2010-07-22 | — | — | US | disclosed |
| US-20100050294-A1 | METHOD FOR MODIFYING INSECT RESISTANCE OF PLANTS BY UTILIZING RNAI TECHNIQUE | SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES CHINESE ACADEMY OF SCIENCES (CN) | 2010-02-25 | — | — | US | disclosed |
| EP-2103690-A1 | METHOD FOR MODIFYING INSECT RESISTANCE OF PLANTS BY UTILIZING RNAI TECHNIQUE | Shanghai Institutes for Biological Sciences Chinese Academy of Sciences (CN) | 2009-09-23 | — | — | EP | disclosed |
| CN-1542057-A | Preparation method of azodiphenylamine yellow disperse dye | 阮加根 | 2004-11-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100050294-A1 | METHOD FOR MODIFYING INSECT RESISTANCE OF PLANTS BY UTILIZING RNAI TECHNIQUE | AGO2, RNGTT, OSR1 | ACHE 2866/4885HSP90AA1 2719/4885GAA 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.