Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33664 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL2371651 | 0.98 | ALDH1A1 (0.64) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL31557927 | 0.89 | ALDH1A1 (0.59) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| Propylene Oxide SCHEMBL5231764 | 0.86 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL27909691 | 0.85 | ALDH1A1 (0.62) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL1761421 | 0.85 | TDP1 (0.53) | ALDH1A1TDP1CYP3A4ALOX15MAPT | |
| SCHEMBL9098717 | 0.84 | TSHR (0.60) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL30539159 | 0.84 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL836536 | 0.84 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL501960 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TDP1CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161904-A1 | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF TOLVAPTAN AND ITS DERIVATIVES | Cambrex Profarmaco Milano S.r.l. (IT) | 2023-04-12 | — | — | EP | disclosed |
| WO-2021249877-A1 | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF TOLVAPTAN AND ITS DERIVATIVES | CAMBREX PROFARMACO MILANO S.R.L. (IT) | 2021-12-16 | — | — | WO | disclosed |
| US-9758658-B2 | Enhanced oilfield swellable elastomers and methods for making and using same | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2017-09-12 | — | — | US | disclosed |
| US-20130096038-A1 | ENHANCED OILFIELD SWELLABLE ELASTOMERS AND METHODS FOR MAKING AND USING SAME | WEATHERFORD/LAMB, INC. (US) | 2013-04-18 | — | — | US | disclosed |
| US-7687571-B2 | Swellable elastomer-based apparatus, oilfield elements comprising same, and methods of using same in oilfield applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2010-03-30 | — | — | US | disclosed |
| US-7631697-B2 | Oilfield apparatus comprising swellable elastomers having nanosensors therein and methods of using same in oilfield application | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2009-12-15 | — | — | US | disclosed |
| US-20080194717-A1 | SWELLABLE ELASTOMER-BASED APPARATUS, OILFIELD ELEMENTS COMPRISING SAME, AND METHODS OF USING SAME IN OILFIELD APPLICATIONS | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-08-14 | — | — | US | disclosed |
| US-20080125335-A1 | Oilfield Apparatus Comprising Swellable Elastomers Having Nanosensors Therein And Methods Of Using Same In Oilfield Application | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-05-29 | — | — | US | disclosed |
| US-7373991-B2 | Swellable elastomer-based apparatus, oilfield elements comprising same, and methods of using same in oilfield applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-05-20 | — | — | US | disclosed |
| US-20070027245-A1 | Swellable Elastomer-Based Apparatus, Oilfield Elements Comprising Same, and Methods of Using Same in Oilfield Applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |
| EP-1209185-B1 | DIAMINOBENZENE DERIVATIVE, POLYIMIDE OBTAINED THEREFROM, AND LIQUID-CRYSTAL ALIGNMENT FILM | NISSAN CHEMICAL IND LTD (JP) | 2006-06-14 | — | — | EP | disclosed |
| US-6740371-B1 | EXCELLENT IN UNIFORMITY; DODECYL (3,5-BIS(4-AMINO BENZOYLAMINO)) BENZOATE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-05-25 | — | — | US | disclosed |
| US-20020183519-A1 | Antithrombotic carboxylic acid amides | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-05 | — | — | US | disclosed |
| EP-1209185-A1 | DIAMINOBENZENE DERIVATIVE, POLYIMIDE OBTAINED THEREFROM, AND LIQUID-CRYSTAL ALIGNMENT FILM | Nissan Chemical Industries, Ltd. (JP) | 2002-05-29 | — | — | EP | disclosed |
| US-4137228-A | HIGH TINCTORIAL STRENGTH, COLORFASTNESS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1979-01-30 | — | — | US | disclosed |
| US-4033945-A | Water-soluble trisazo 8-amino-naphthol-1 dyes | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1977-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183519-A1 | Antithrombotic carboxylic acid amides | SERPINC1, TFPI, F2 | ALDH1A1 83/4885TDP1 1147/4885CYP3A4 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.