Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3136984

CN(C)C(=O)CCc1ccccc1.Cl

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 known ✓ Q92769 2/20 0.50
HDAC8 known ✓ Q9BY41 2/20 0.50
HDAC6 known ✓ Q9UBN7 2/20 0.50
HDAC3 known ✓ O15379 1/20 0.48
ADRA1A known ✓ P35348 1/20 0.48
HDAC4 known ✓ P56524 1/20 0.48
SLC6A3 known ✓ Q01959 1/20 0.48
HDAC1 known ✓ Q13547 1/20 0.48
HDAC7 known ✓ Q8WUI4 1/20 0.48
HDAC10 known ✓ Q969S8 1/20 0.48
HDAC11 known ✓ Q96DB2 1/20 0.48
HDAC9 known ✓ Q9UKV0 1/20 0.48
HDAC5 known ✓ Q9UQL6 1/20 0.48
SIGMAR1 known ✓ Q99720 1/20 0.48
KMT2A Q03164 3/20 0.68
ALDH1A1 P00352 1/20 0.59
MEN1 O00255 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
HTT P42858 1/20 0.57
KEAP1 Q14145 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9130864 0.98 KMT2A (0.66) KMT2AALDH1A1MEN1L3MBTL1HTT
SCHEMBL3366949 0.98 KMT2A (0.70) KMT2AALDH1A1MEN1L3MBTL1HTT
Water SCHEMBL3678915 0.96 KMT2A (0.68) KMT2AALDH1A1MEN1L3MBTL1HTT
Hydrochloric Acid SCHEMBL27410606 0.89 ALOX5 (0.67) KMT2AALDH1A1ALOX5NPC1RAB9A
SCHEMBL7088866 0.87 FFAR1 (0.65) KMT2AALDH1A1MEN1L3MBTL1HTT
SCHEMBL8493143 0.86 ALOX5 (0.69) KMT2AALDH1A1ALOX5NPC1RAB9A
SCHEMBL386559 0.85 ALOX5 (0.77) KMT2AALOX5HDAC2HDAC8HDAC6
Hydrochloric Acid SCHEMBL6165650 0.85 KMT2A (0.64) KMT2AALDH1A1MEN1L3MBTL1HTT
SCHEMBL448875 0.84 ALOX5 (0.77) KMT2AALDH1A1MEN1L3MBTL1HTT
SCHEMBL7073173 0.84 KMT2A (0.54) KMT2AALDH1A1MEN1L3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114026068-A EP2 antagonists 小野药品工业株式会社 2022-02-08 CN disclosed
EP-1636224-B1 PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE PROSIDION LTD (GB) 2010-07-14 EP disclosed
CN-100480249-C Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors PROSIDION LTD (GB) 2009-04-22 CN disclosed
CN-1826340-A Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors PROSIDION LTD (GB) 2006-08-30 CN disclosed
US-20060140888-A1 Whitening agent containing crystalline molecular complex of hydroquinone and surfactant CIRCLE FOR THE PROMOTION OF SCIENCE AND ENGINEERING, THE (JP) 2006-06-29 US disclosed
EP-1636224-A2 PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE Prosidion Limited (GB) 2006-03-22 EP disclosed
WO-2004104001-A2 PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE PROSIDION LIMITED (GB) 2004-12-02 WO disclosed
EP-1072591-A1 NOVEL UREA DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 2001-01-31 EP disclosed
EP-1051210-A2 ENHANCED BIOCOMPATIBILITY COATINGS FOR MEDICAL IMPLANTS Edwards Lifesciences Corporation (US) 2000-11-15 EP disclosed
WO-1999038547-A2 ENHANCED BIOCOMPATIBILITY COATINGS FOR MEDICAL IMPLANTS EDWARDS LIFESCIENCES CORPORATION (US) 1999-08-05 WO disclosed
CN-1142492-A Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents PFIZER (US) 1997-02-12 CN disclosed
US-5382492-A Thermoplastic resin particles, nonpolar liquids and benzyl acetyldimethylammonium chloride XEROX CORPORATION (US) 1995-01-17 US disclosed
US-4824532-A Process for the electrochemical synthesis of carboxylic acids SOCIETE NATIONALE INDUSTRIELLE ET AEROSPATIALE DES POUDRES ET (FR) 1989-04-25 US disclosed