Gusperimus

Gusperimus

SCHEMBL317327

Cl.N=C(N)NCCCCCCC(=O)NC(O)C(=O)NCCCCNCCCN

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Gusperimus. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRNB4 known ✓ P30926 2/20 0.43
CHRNA3 known ✓ P32297 2/20 0.43
GRIN1 known ✓ Q05586 1/20 0.43
GRIN2A known ✓ Q12879 1/20 0.43
GRIA1 P42261 8/20 0.46
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
GRM1 Q13255 1/20 0.43
PAOX Q6QHF9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gusperimus SCHEMBL7320030 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Gusperimus SCHEMBL26925 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Gusperimus SCHEMBL12980163 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL9772175 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL9772231 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL9772186 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Gusperimus SCHEMBL317912 1.00 GRIA1 (0.46) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Gusperimus SCHEMBL10910437 0.99 GRIA1 (0.45) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL9772173 0.99 GRIA1 (0.47) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL9772154 0.99 GRIA1 (0.44) GRIA1CHRNB2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 465 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4745155-A1 POWDER CONTAINING PARTICLES OF GELATIN DERIVATIVE AND APPLICATION OF SAME IN MEDICAL TREATMENT National Institute for Materials Science (JP) 2026-05-20 EP claimed
WO-2025013818-A1 POWDER CONTAINING PARTICLES OF GELATIN DERIVATIVE AND APPLICATION OF SAME IN MEDICAL TREATMENT 国立研究開発法人物質・材料研究機構 2025-01-16 WO claimed
US-9675696-B2 Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain WARSAW ORTHOPEDIC, INC. (US) 2017-06-13 US claimed
EP-2104505-B1 METHOD AND USE FOR INCREASING EFFICACY OF ANTI-ADHESIVE COMPOSITIONS IN CONTROLLING INFLAMMATION AND PAIN WARSAW ORTHOPEDIC INC (US) 2014-05-21 EP claimed
US-8617603-B2 Coated tablet NIPPON SHINYAKU CO., LTD. (JP) 2013-12-31 US claimed
EP-2057985-B1 Tablet coated with a polyvinyl alcohol copolymer NIPPON SHINYAKU CO LTD (JP) 2013-10-16 EP claimed
US-20130004577-A1 COATED TABLET NIPPON SHINYAKU (JP) 2013-01-03 US claimed
EP-2465513-A2 Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain Warsaw Orthopedic, Inc. (US) 2012-06-20 EP claimed
US-7901453-B2 Coated implantable medical device COOK INCORPORATED (US) 2011-03-08 US claimed
EP-1010435-B1 NANOCAPSULE PREPARATIONS FOR TREATING INTRAARTICULAR DISEASES MARUHO K K (JP) 2010-11-03 EP claimed
US-20080145399-A1 coronary stent has a multilayer coatings for controlled release of immunosuppressive agent active materials, including a porous cover layer COOK MEDICAL TECHNOLOGIES LLC 2008-06-19 US claimed
WO-2008063943-A2 METHOD AND USE FOR INCREASING EFFICACY OF ANTI-ADHESIVE COMPOSITIONS IN CONTROLLING INFLAMMATION AND PAIN WARSAW ORTHOPEDIC, INC. (US) 2008-05-29 WO claimed
US-20080112921-A1 Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain WARSAW ORTHOPEDIC, INC. 2008-05-15 US claimed
US-20060293391-A1 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES EURO NIPPON KAYAKU GMBH (DE) 2006-12-28 US claimed
US-7153887-B1 Use of 15-deoxyspergualin for the treatment of ANCA associated vasculitis EURO NIPPON KAYAKU GMBH (DE) 2006-12-26 US claimed
US-20050261762-A1 Medical devices to prevent or inhibit restenosis MEDTRONIC VASCULAR, INC. (US) 2005-11-24 US claimed
US-20030036794-A1 Coated implantable medical device COOK INCORPORATED 2003-02-20 US claimed
EP-1180026-B1 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES EURO NIPPON KAYAKU GMBH (DE) 2002-12-04 EP claimed
EP-1180026-A2 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES Euro Nippon Kayaku GmbH (DE) 2002-02-20 EP claimed
WO-2000071103-A2 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES EURO NIPPON KAYAKU GMBH (DE) 2000-11-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060293391-A1 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES SHBG, HSD17B11, NR5A1 CHRNB4 1355/4885CHRNA3 1187/4885GRIN1 1385/4885
US-20080112921-A1 Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain ICAM1, MMP8, VCAM1 CHRNB4 847/4885CHRNA3 665/4885GRIN1 1028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.