Hydrochloric Acid

Hydrochloric Acid

SCHEMBL329165

CCCC(N)C(O)C(=O)NC1CC1.Cl

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SIGMAR1 known ✓ Q99720 1/20 0.36
SMYD3 Q9H7B4 1/20 0.42
METAP2 P50579 9/20 0.40
METAP1 P53582 3/20 0.40
LMNA P02545 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
MME P08473 1/20 0.35
ANPEP P15144 1/20 0.35
DNPEP Q9ULA0 1/20 0.35
GPR88 Q9GZN0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4205427 1.00 SMYD3 (0.42) SMYD3METAP2METAP1LMNABLM
Hydrochloric Acid SCHEMBL3511596 1.00 SMYD3 (0.42) SMYD3METAP2METAP1LMNABLM
Hydrochloric Acid SCHEMBL329085 1.00 SMYD3 (0.42) SMYD3METAP2METAP1LMNABLM
Hydrochloric Acid SCHEMBL328872 1.00 SMYD3 (0.42) SMYD3METAP2METAP1LMNABLM
Hydrochloric Acid SCHEMBL29618100 1.00 SMYD3 (0.42) SMYD3METAP2METAP1LMNABLM
SCHEMBL3045972 0.98 SMYD3 (0.43) SMYD3METAP2METAP1LMNABLM
SCHEMBL329193 0.98 SMYD3 (0.43) SMYD3METAP2METAP1LMNABLM
SCHEMBL329101 0.98 SMYD3 (0.43) SMYD3METAP2METAP1LMNABLM
SCHEMBL2331995 0.98 SMYD3 (0.43) SMYD3METAP2METAP1LMNABLM
SCHEMBL13058644 0.98 SMYD3 (0.43) SMYD3METAP2METAP1LMNABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104293844-B A kind of synthetic method of Telaprevir intermediate 苏州永健生物医药有限公司 2017-10-10 CN claimed
CN-104293844-A Synthetic method of telaprevir intermediate SUZHOU UUGENE BIOPHARMA CO LTD 2015-01-21 CN claimed
WO-2014083582-A2 NOVEL PROCESS FOR THE PREPARATION OF (1S,3AR,6AS)-2-[(2S)-2-({(2S)-2-CYCLOHEXYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO]ACETYL}AMINO)-3,3-DIMETHYLBUTANOYL]-N-[(3S)-1-(CYCLOPROPYLAMINO)-1,2-DIOXOHEXAN-3-YL]-3,3A,4,5,6,6A-HEXAHYDRO-1H-CYCLOPENTA[C] PYRROLE-1-CARBOXAMIDE AND ITS INTERMEDIATES MSN LABORATORIES LIMITED (IN) 2014-06-05 WO claimed
CN-102702015-A Preparation method of (2S, 3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride Zhejiang xinhua pharmaceutical co ltd 2012-10-03 CN claimed
CN-114539125-B Synthesis method of paciclovir intermediate 杭州国瑞生物科技有限公司 2024-02-09 CN disclosed
WO-2023168827-A1 SYNTHESIS METHOD FOR PAXLOVID INTERMEDIATE 杭州国瑞生物科技有限公司 2023-09-14 WO disclosed
CN-114539125-A Synthetic method of pasiclovir intermediate 杭州国瑞生物科技有限公司 2022-05-27 CN disclosed
CN-104293844-B A kind of synthetic method of Telaprevir intermediate 苏州永健生物医药有限公司 2017-10-10 CN disclosed
CN-105085310-A New synthesis method of telaprevir intermediate CHONGQING HUIZHI PHARMACEUTICAL RES INST CO LTD 2015-11-25 CN disclosed
CN-104812733-A A method for the preparation of 3-amino-n-cyclopropyl-2-hydroxyl-hexanamide JANSSEN PHARMACEUTICA NV 2015-07-29 CN disclosed
CN-103435532-B Synthetic method of boceprevir intermediate SUZHOU UUGENE BIOPHARMA CO LTD 2015-07-08 CN disclosed
EP-2861557-A1 A METHOD FOR THE PREPARATION OF 3-AMINO-N-CYCLOPROPYL-2-HYDROXYL-HEXANAMIDE Janssen Pharmaceutica, N.V. (BE) 2015-04-22 EP disclosed
US-20090312577-A1 Process for Production of Beta-Amino-Alpha-Hydroxy Carbonxamide Derivative KANEKA CORPORATION (JP) 2009-12-17 US disclosed
WO-2009081608-A1 PROCESS FOR PRODUCING N-CYCLOPROPYL-3-AMINO-2-HYDROXYHEXANOIC ACID AMIDE HYDROCHLORIDE KANEKA CORPORATION (JP) 2009-07-02 WO disclosed
CN-101454274-A Processes and intermediates for preparing steric compounds VERTEX PHARMA (US) 2009-06-10 CN disclosed
EP-2039689-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-2 -HYDROXYPROPIONIC CYCLOPROPYLAMIDE DERIVATIVES AND SALTS THEREOF Kaneka Corporation (JP) 2009-03-25 EP disclosed
EP-1993993-A1 PROCESSES AND INTERMEDIATES FOR PREPARING STERIC COMPOUNDS Vertex Pharmaceuticals Incorporated (US) 2008-11-26 EP disclosed
EP-1988073-A1 PROCESS FOR PRODUCTION OF BETA-AMINO-ALPHA-HYDROXY ACID AMIDE DERIVATIVE Kaneka Corporation (JP) 2008-11-05 EP disclosed
US-20070244334-A1 Processes and intermediates for preparing steric compounds VERTEX PHARMACEUTICALS INCORPORATED 2007-10-18 US disclosed
WO-2007109023-A1 PROCESSES AND INTERMEDIATES FOR PREPARING STERIC COMPOUNDS VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312577-A1 Process for Production of Beta-Amino-Alpha-Hydroxy Carbonxamide Derivative PTMA, ATIC, HCAR2 SIGMAR1 796/4885SMYD3 4666/4885METAP2 1578/4885
US-20070244334-A1 Processes and intermediates for preparing steric compounds REV1, HSD11B1, CYP11B1 SIGMAR1 465/4885SMYD3 4359/4885METAP2 1514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.