Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | EYA2 | O00167 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551330 | 0.98 | TDP1 (0.33) | FAAHTDP1EYA2APPACE | |
| SCHEMBL3435871 | 0.85 | FAAH (0.36) | FAAHTDP1EYA2APPACE | |
| SCHEMBL27712183 | 0.81 | SMN1; SMN2 (0.35) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL3674964 | 0.79 | — | — | |
| SCHEMBL8817028 | 0.79 | TDP1 (0.33) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL8665225 | 0.76 | FFAR3 (0.35) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL3658176 | 0.75 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL3786123 | 0.75 | TDP1 (0.36) | FAAHTDP1EYA2APPACE | |
| SCHEMBL8527819 | 0.74 | TDP1 (0.33) | TDP1EYA2APPACEKDM4E | |
| SCHEMBL3453847 | 0.74 | TDP1 (0.39) | TDP1EYA2APPACEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062292-B1 | PROCESS FOR THE PREPARATION OF A COOLING EMULSION, AND ITS APPLICATION | Meinhardt, Horst (DE) | 1986-01-22 | — | — | EP | claimed |
| US-20210290690-A1 | COMPOSITIONS OF MORSELIZED UMBILICAL CORD AND/OR AMNIOTIC MEMBRANE AND METHODS OF USE THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION | 2021-09-23 | — | — | US | disclosed |
| US-11116800-B2 | Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof | TISSUETECH, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-10632155-B2 | Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition | TISSUETECH, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-10463890-B2 | Method for preparing broccoli with increased sulforaphane content and use of broccoli prepared thereby | BKBIO CO., LTD. (KR) | 2019-11-05 | — | — | US | disclosed |
| EP-2664337-B1 | Amniotic membrane preparations and purified compositions and methods of use | TISSUETECH INC (US) | 2019-08-14 | — | — | EP | disclosed |
| US-10272119-B2 | Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition | TISSUETECH, INC. (US) | 2019-04-30 | — | — | US | disclosed |
| EP-1933852-B1 | AMNIOTIC MEMBRANE PREPARATIONS AND PURIFIED COMPOSITIONS AND METHODS OF USE | TISSUETECH INC (US) | 2018-12-19 | — | — | EP | disclosed |
| US-20180318356-A1 | DERMATOLOGICAL AND COSMETIC TREATMENTS USING MESENCHYMAL STEM CELLS | KPBKR LLC | 2018-11-08 | — | — | US | disclosed |
| US-20180193252-A1 | Cosmetic Compositions and Method of Making the Same | SERUCELLBIO, INC. | 2018-07-12 | — | — | US | disclosed |
| EP-0389950-A1 | Melanocyte-stimulating hormone inhibitor and external preparation containing the same | LION CORPORATION (JP) | 1990-10-03 | — | — | EP | disclosed |
| CN-1042912-A | (1H-oxazol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1990-06-13 | — | — | CN | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371559-A2 | Use of benzimidazoles in the treatment of epithelial disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |
| EP-0335442-A2 | Agents for preserving or restoring the soundness of the skin | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-10-04 | — | — | EP | disclosed |
| EP-0332847-A2 | Composition for preventing graying of the hair and restoring grayed hair to its natural color | LION CORPORATION (JP) | 1989-09-20 | — | — | EP | disclosed |
| EP-0294808-A1 | Agent for external application and use thereof | LION CORPORATION (JP) | 1988-12-14 | — | — | EP | disclosed |
| EP-0293837-A2 | Composition for application to hair or scalp | Sugiyama, Keikichi (JP) | 1988-12-07 | — | — | EP | disclosed |
| EP-0260697-A2 | Composition for application to hair | LION CORPORATION (JP) | 1988-03-23 | — | — | EP | disclosed |
| EP-0256472-A2 | Cosmetic agent for application to skin | LION CORPORATION (JP) | 1988-02-24 | — | — | EP | disclosed |