Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 7/20 | 0.78 |
| ▸ | THRA known ✓ | P10827 | 4/20 | 0.59 |
| ▸ | PPARG known ✓ | P37231 | 2/20 | 0.59 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.59 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.59 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.59 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.59 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.59 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.59 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.59 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.59 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.59 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.59 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.59 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.59 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.59 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.59 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.59 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.59 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL41654 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL29378991 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL29684887 | 0.88 | THRB (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL428139 | 0.87 | PCNA (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL445767 | 0.87 | PCNA (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL1487713 | 0.87 | PCNA (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Detrothyronine SCHEMBL41655 | 0.86 | USP2 (1.00) | THRBMEN1KMT2ALMNAUSP2 | |
| Water SCHEMBL28780879 | 0.86 | PCNA (0.97) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL4439595 | 0.86 | PCNA (0.97) | THRBMEN1KMT2ALMNAUSP2 | |
| Water SCHEMBL28780882 | 0.86 | PCNA (0.97) | THRBMEN1KMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090297566-A1 | Oxygen-impervious packaging with optional oxygen scavenger, stabilized thyroid hormone compositions and methods for storing thyroid hormone pharmaceutical compositions | KING PHARMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| EP-1835897-A2 | OXYGEN-IMPERVIOUS PACKAGING WITH OPTIONAL OXYGEN SCAVENGER, STABILIZED THYROID HORMONE COMPOSITIONS AND METHODS FOR STORING THYROID HORMONE PHARMACEUTICAL COMPOSITIONS | King Pharmaceuticals Research and Development Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060183804-A1 | Oxygen-impervious packaging with optional oxygen scavenger, stabilized thyroid hormone compositions and methods for storing thyroid hormone pharmaceutical compositions | CREDIT SUISSE AG | 2006-08-17 | — | — | US | disclosed |
| WO-2006071844-A2 | OXYGEN-IMPERVIOUS PACKAGING AND METHODS FOR STORING THYROID HORMONE | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183804-A1 | Oxygen-impervious packaging with optional oxygen scavenger, stabilized thyroid hormone compositions and methods for storing thyroid hormone pharmaceutical compositions | TPO, TSHR, TRHDE | THRB 7/4885THRA 4/4885PPARG 328/4885 |
| US-20090297566-A1 | Oxygen-impervious packaging with optional oxygen scavenger, stabilized thyroid hormone compositions and methods for storing thyroid hormone pharmaceutical compositions | TPO, TSHR, THRA | THRB 8/4885THRA 3/4885PPARG 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.