Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 6/20 | 0.46 |
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.44 |
| ▸ | PPARG known ✓ | P37231 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27790636 | 0.99 | IDO1 (0.47) | IDO1MMP12MAOBKMT2AMMP1 | |
| Hydrochloric Acid SCHEMBL4489763 | 0.86 | MAPT (0.45) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL6921092 | 0.85 | IDO1 (0.55) | IDO1MMP12MAOBKMT2AMMP1 | |
| SCHEMBL5369304 | 0.84 | MAPT (0.46) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL4481340 | 0.84 | ALDH1A1 (0.48) | IDO1MMP12MAOBKMT2AMMP1 | |
| Hydrochloric Acid SCHEMBL27554654 | 0.84 | KDM4E (0.43) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL27790571 | 0.82 | LMNA (0.41) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL4474551 | 0.81 | MEN1 (0.55) | IDO1MMP12MAOBKMT2AMMP1 | |
| Hydrochloric Acid SCHEMBL1177366 | 0.81 | MAPT (0.52) | MMP12KMT2AMMP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1177668 | 0.80 | ALDH1A1 (0.56) | KMT2AALDH1A1MAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563819-B1 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | PHOTOCURE ASA (NO) | 2009-07-21 | — | — | US | disclosed |
| US-7287646-B2 | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy | PHOTOCURE ASA (NO) | 2007-10-30 | — | — | US | disclosed |
| CN-1318388-C | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | PHOTOCURE A S (NO) | 2007-05-30 | — | — | CN | disclosed |
| US-7217736-B2 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | PHOTOCURE ASA (NO) | 2007-05-15 | — | — | US | disclosed |
| EP-1313695-B1 | ESTERS OF 5-AMINOLEVULINIC ACID AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY | PHOTOCURE ASA (NO) | 2006-12-27 | — | — | EP | disclosed |
| US-6992107-B1 | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy | PHOTOCURE ASA (NO) | 2006-01-31 | — | — | US | disclosed |
| US-20050107471-A1 | NEW ESTERS OF 5-AMINOLEVULINIC ACID AND THEIR USE AS PHOTOSENSITIZING COMPOUNDS IN PHOTOCHEMOTHERAPY | GIERSKCKY KARL E (NO) | 2005-05-19 | — | — | US | disclosed |
| US-20040106679-A1 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | PHOTOCURE ASA (NO) | 2004-06-03 | — | — | US | disclosed |
| CN-1460099-A | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | PHOTOCURE AS (NO) | 2003-12-03 | — | — | CN | disclosed |
| EP-1313695-A1 | ESTERS OF 5-AMINOLEVULINIC ACID AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY | Photocure ASA (NO) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010120-A1 | ESTERS OF 5-AMINOLEVULINIC ACID AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY | PHOTOCURE ASA (NO) | 2002-02-07 | — | — | WO | disclosed |