Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 known ✓ | O95136 | 5/20 | 0.43 |
| ▸ | S1PR4 known ✓ | O95977 | 5/20 | 0.43 |
| ▸ | S1PR1 known ✓ | P21453 | 5/20 | 0.43 |
| ▸ | S1PR3 known ✓ | Q99500 | 5/20 | 0.43 |
| ▸ | S1PR5 known ✓ | Q9H228 | 1/20 | 0.43 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.42 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PPARG known ✓ | P37231 | 4/20 | 0.39 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 3/20 | 0.39 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.39 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.39 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133298 | 0.98 | TSHR (0.46) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL15263821 | 0.92 | RELA (0.38) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL355144 | 0.92 | PAOX (0.43) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL31347643 | 0.92 | PAOX (0.49) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL11588468 | 0.91 | TSHR (0.39) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL11585916 | 0.91 | TSHR (0.39) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL5880662 | 0.91 | PAOX (0.42) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL4945383 | 0.90 | TSHR (0.42) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Edetic Acid SCHEMBL10949676 | 0.89 | TDP1 (0.52) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Nitrilotriacetic Acid SCHEMBL1118282 | 0.89 | TSHR (0.52) | TSHRALDH1A1S1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115428128-A | Hollow microspheres | 株式会社德山 | 2022-12-02 | — | — | CN | disclosed |
| CN-115379926-A | Hollow microspheres for CMP polishing pads | 株式会社德山 | 2022-11-22 | — | — | CN | disclosed |
| US-20140349969-A1 | COMPOUNDS AND METHODS FOR TREATING PAIN | AKRON MOLECULES AG (AT) | 2014-11-27 | — | — | US | disclosed |
| EP-2674161-A1 | FMO3 inhibitors for treating pain | Akron Molecules GmbH (AT) | 2013-12-18 | — | — | EP | disclosed |
| US-20130252924-A1 | Compounds and Methods for Treating Pain | AKRON MOLECULES GMBH (AT) | 2013-09-26 | — | — | US | disclosed |
| EP-2637649-A2 | COMPOUNDS AND METHODS FOR TREATING PAIN | Akron Molecules GmbH (AT) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062925-A2 | COMPOUNDS AND METHODS FOR TREATING PAIN | AKRON MOLECULES GMBH (AT) | 2012-05-18 | — | — | WO | disclosed |
| US-7364723-B1 | Liquid preparation for contact lenses | MENICON CO., LTD. (JP) | 2008-04-29 | — | — | US | disclosed |
| CN-101027986-A | Compound disinfectant | QUAN LIMIN (CN) | 2007-09-05 | — | — | CN | disclosed |
| US-7258904-B2 | Absorber and method for producing it | SONY CORPORATION (JP) | 2007-08-21 | — | — | US | disclosed |
| EP-0947203-B1 | Agent for contact lenses | MENICON CO LTD (JP) | 2003-02-26 | — | — | EP | disclosed |
| EP-1214883-A1 | LIQUID PREPARATION FOR CONTACT LENSES | MENICON CO., LTD. (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-20020039629-A1 | Water absorber and method for fabricating the same | SONY CORPORATION (JP) | 2002-04-04 | — | — | US | disclosed |
| EP-1186344-A2 | Water absorber and method for fabricating the same | SONY CORPORATION (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-20010021752-A1 | Antimicrobial agent and production process thereof | SONY CORPORATION | 2001-09-13 | — | — | US | disclosed |
| EP-1132412-A1 | Antimicrobial agent and production process thereof | SONY CORPORATION (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-6177480-B1 | MIXTURE OF WATER AND SMECTITE; CLEANING, PRESERVATIVE, RINSING, STABILIZING | MENICON CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6121327-A | MIXTURE OF NITROGEN DISINFECTANT, ALCOHOL AND BIS(2-HYDROXYETHYL)IMINOTRI(HYDROXYMETHYL)METHANE | MENICON CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0958836-A2 | Contact lens disinfecting solution | Menicon Co., Ltd. (JP) | 1999-11-24 | — | — | EP | disclosed |
| EP-0947203-A2 | Agent for contact lenses | Menicon Co., Ltd. (JP) | 1999-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349969-A1 | COMPOUNDS AND METHODS FOR TREATING PAIN | TRPV1, ACHE, OPRL1 | S1PR2 475/4885S1PR4 474/4885S1PR1 584/4885 |
| US-20130252924-A1 | Compounds and Methods for Treating Pain | TRPV1, ACHE, OPRL1 | S1PR2 475/4885S1PR4 474/4885S1PR1 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.