Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 4/20 | 0.51 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.45 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.42 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.41 |
| ▸ | ITK known ✓ | Q08881 | 1/20 | 0.41 |
| ▸ | RET known ✓ | P07949 | 2/20 | 0.40 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31035997 | 1.00 | KDR (0.51) | KDRCHEK1AOC3RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL3675763 | 1.00 | KDR (0.51) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL2563486 | 0.98 | KDR (0.53) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL29419326 | 0.98 | KDR (0.53) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL29733654 | 0.98 | KDR (0.53) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL8965829 | 0.83 | RAB9A (0.58) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL29361867 | 0.82 | KDR (0.58) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL221259 | 0.82 | KDR (0.58) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL9469591 | 0.82 | RAB9A (0.58) | KDRCHEK1AOC3RAB9ANPC1 | |
| SCHEMBL9469103 | 0.78 | KDR (0.46) | KDRCHEK1AOC3RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599337-B1 | Method for detection of nucleic acid and probe therefor | CANON KK (JP) | 2006-03-08 | — | — | EP | claimed |
| US-20190002832-A1 | HUMANIZED MOUSE MODEL OF MYASTHENIA GRAVIS AND MSC THERAPY | ASSOCIATION INSTITUT DE MYOLOGIE (FR) | 2019-01-03 | — | — | US | disclosed |
| EP-2874654-B1 | NOVEL ARTERIVIRUS PROTEIN AND EXPRESSION MECHANISMS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2018-11-28 | — | — | EP | disclosed |
| EP-3393236-A1 | HUMANIZED MOUSE MODEL OF MYASTHENIA GRAVIS AND MSC THERAPY | Association Institut de Myologie (FR) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017109204-A1 | HUMANIZED MOUSE MODEL OF MYASTHENIA GRAVIS AND MSC THERAPY | ASSOCIATION INSTITUT DE MYOLOGIE (FR) | 2017-06-29 | — | — | WO | disclosed |
| US-9623103-B2 | Arterivirus protein and expression mechanisms | SOUTH DAKOTA BOARD OF REGENTS (US) | 2017-04-18 | — | — | US | disclosed |
| EP-3009948-A2 | NOVEL ARTERIVIRUS PROTEIN AND EXPRESSION MECHANISMS | Cambridge Enterprise Limited (GB) | 2016-04-20 | — | — | EP | disclosed |
| US-20150190495-A1 | ARTERIVIRUS PROTEIN AND EXPRESSION MECHANISMS | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2015-07-09 | — | — | US | disclosed |
| US-20040043047-A1 | Cosmetic or dermatological compositions containing at least one substance for increasing the functionality and/or expression of the CD44 membrane receptors of skin cells | PARFUMS CHRISTIAN DIOR (FR) | 2004-03-04 | — | — | US | disclosed |
| US-20020106674-A1 | In situ assay of substance in biological sample using labeled probe | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2002-08-08 | — | — | US | disclosed |
| US-6339172-B1 | REACTING LABELED NUCLEIC ACID PROBE WITH AN OBJECTIVE SUBSTANCE ON A BIOLOGICAL SAMPLE SELECTED FROM TISSUE, CELL AND CHROMOSOME ADDING HEAVY METAL AND ASSAYING FLUORESCENCE OF COMPLEX FORMED | Matsumoto, Kazuko (JP) | 2002-01-15 | — | — | US | disclosed |