Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cocarboxylase. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | TKT | P29401 | 7/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PPP5C | P53041 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cocarboxylase SCHEMBL23151792 | 0.99 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL991346 | 0.99 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL8923435 | 0.99 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL21111 | 0.99 | LMNA (0.98) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19138210 | 0.98 | LMNA (0.93) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL4315554 | 0.98 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL23151791 | 0.98 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL23151784 | 0.98 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL344290 | 0.98 | LMNA (0.96) | LMNATKTTDP1HSP90AA1ALDH1A1 | |
| Cocarboxylase SCHEMBL30192281 | 0.98 | LMNA (1.00) | LMNATKTTDP1HSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160160176-A1 | REDUCING THE IMMUNOGENICITY OF ALLOGRAFTS | BREONICS, INC. | 2016-06-09 | — | — | US | claimed |
| EP-2367530-B1 | SOLUTIONS FOR VOLUME THERAPY | FRESENIUS KABI DE GMBH (DE) | 2013-05-01 | — | — | EP | claimed |
| CN-102256593-A | Solutions for volume therapy | FRESENIUS KABI DE GMBH | 2011-11-23 | — | — | CN | claimed |
| US-20110257090-A1 | SOLUTIONS FOR VOLUME THERAPY | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2011-10-20 | — | — | US | claimed |
| EP-2367530-A2 | SOLUTIONS FOR VOLUME THERAPY | Fresenius Kabi Deutschland GmbH (DE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010078935-A2 | SOLUTIONS FOR VOLUME THERAPY | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2010-07-15 | — | — | WO | claimed |
| EP-1021084-A4 | SOLUTION AND PROCESS FOR RESUSCITATION AND REPARATION OF ISCHEMICALLY DAMAGED TISSUE | BREONICS INC (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1164841-B9 | PHYSIOLOGICAL MEDIUM FOR PERFUSING, PRESERVING AND STORING ISOLATED CELL, TISSUE AND ORGAN SAMPLES | RES DEL INTERNAT LTD (GB) | 2004-01-02 | — | — | EP | claimed |
| US-20030077655-A1 | Physiological medium for perfusing, preserving and storing isolated cell, tissue and organ samples | RES-DEL INTERNATIONAL LIMITED (GB) | 2003-04-24 | — | — | US | claimed |
| EP-1164841-B1 | PHYSIOLOGICAL MEDIUM FOR PERFUSING, PRESERVING AND STORING ISOLATED CELL, TISSUE AND ORGAN SAMPLES | RES DEL INTERNAT LTD (GB) | 2003-04-09 | — | — | EP | claimed |
| EP-1164841-A1 | PHYSIOLOGICAL MEDIUM FOR PERFUSING, PRESERVING AND STORING ISOLATED CELL, TISSUE AND ORGAN SAMPLES | Res-Del International Limited (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2001052647-A1 | PHYSIOLOGICAL MEDIUM FOR PERFUSING, PRESERVING AND STORING ISOLATED CELL, TISSUE AND ORGAN SAMPLES | RES-DEL INTERNATIONAL LIMITED (GB) | 2001-07-26 | — | — | WO | claimed |
| EP-1021084-A1 | SOLUTION AND PROCESS FOR RESUSCITATION AND REPARATION OF ISCHEMICALLY DAMAGED TISSUE | Breonics, Inc. (US) | 2000-07-26 | — | — | EP | claimed |
| US-5843024-A | Solution and process for resuscitation and preparation of ischemically damaged tissue | BREONICS, INC. (US) | 1998-12-01 | — | — | US | claimed |
| WO-1997043899-A1 | SOLUTION AND PROCESS FOR RESUSCITATION AND REPARATION OF ISCHEMICALLY DAMAGED TISSUE | BREONICS, INC. (US) | 1997-11-27 | — | — | WO | claimed |
| EP-4709188-A1 | PHARMACEUTICAL OR COSMETIC COMPOSITION FOR REDUCING SEBUM PRODUCTION ON THE SCALP | Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) | 2026-03-18 | — | — | EP | disclosed |
| CN-119121243-B | Electrolytic copper foil surface treatment process | 广东嘉元科技股份有限公司 | 2026-02-06 | — | — | CN | disclosed |
| US-5843024-A | Solution and process for resuscitation and preparation of ischemically damaged tissue | BREONICS, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| WO-1998020332-A1 | BIOSENSOR INCORPORATING A SURFACTANT | SENSALYSE HOLDINGS LIMITED (GB) | 1998-05-14 | — | — | WO | disclosed |
| WO-1997043899-A1 | SOLUTION AND PROCESS FOR RESUSCITATION AND REPARATION OF ISCHEMICALLY DAMAGED TISSUE | BREONICS, INC. (US) | 1997-11-27 | — | — | WO | disclosed |