Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 0.57 |
| ▸ | S1PR4 known ✓ | O95977 | 1/20 | 0.41 |
| ▸ | S1PR1 known ✓ | P21453 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29240 | 0.98 | ACHE (0.59) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL29562542 | 0.98 | ACHE (0.59) | ACHEKDM4ENPC1S1PR4MAPT | |
| Nitric Acid SCHEMBL29563050 | 0.90 | ACHE (0.55) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL3972008 | 0.85 | ACHE (0.74) | ACHE | |
| SCHEMBL29411838 | 0.85 | ACHE (0.74) | ACHE | |
| SCHEMBL4670865 | 0.77 | MAPT (0.39) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL7091234 | 0.76 | ALDH1A1 (0.57) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL19329417 | 0.73 | ATM (0.50) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL2315874 | 0.73 | ATM (0.50) | ACHEKDM4ENPC1S1PR4MAPT | |
| SCHEMBL6904073 | 0.72 | ACHE (1.00) | ACHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193315-B2 | Excitatory glycine receptors and methods | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-06-05 | — | — | US | disclosed |
| US-20120046446-A1 | p16 MEDIATED REGULATION OF NMDA RECEPTORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-02-23 | — | — | US | disclosed |
| US-20110045098-A1 | EXCITATORY GLYCINE RECEPTORS AND METHODS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-02-24 | — | — | US | disclosed |
| US-7790404-B2 | Excitatory glycine receptors and methods | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100160607-A1 | p16 MEDIATED REGULATION OF NMDA RECEPTORS | NATIONAL INSTITUTES OF HEALTH - DIRETOR DEITR | 2010-06-24 | — | — | US | disclosed |
| US-7544478-B2 | Method for screening for compounds that modulate P16 mediated regulation of NMDA receptors | THE BURNHAM INSTITUTE (US) | 2009-06-09 | — | — | US | disclosed |
| EP-1660634-A4 | P16 MEDIATED REGULATION OF NMDA RECEPTORS | BURNHAM INST (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1578909-A4 | EXCITATORY GLYCINE RECEPTORS AND METHODS | BURNHAM INST (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1660634-A2 | P16 MEDIATED REGULATION OF NMDA RECEPTORS | The Burnham Institute (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1578909-A2 | EXCITATORY GLYCINE RECEPTORS AND METHODS | The Burnham Institute (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050037433-A1 | p16 mediated regulation of NMDA receptors | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-02-17 | — | — | US | disclosed |
| WO-2005014797-A2 | P16 MEDIATED REGULATION OF NMDA RECEPTORS | THE BURNHAM INSTITUTE (US) | 2005-02-17 | — | — | WO | disclosed |
| US-20040033500-A1 | Excitatory glycine receptors and methods | THE BURNHAM INSTITUTE | 2004-02-19 | — | — | US | disclosed |
| US-20030092004-A1 | Excitatory glycine receptors and methods | LIPTON STUART A (US) | 2003-05-15 | — | — | US | disclosed |
| WO-2003016479-A2 | EXCITATORY GLYCINE RECEPTORS AND METHODS | THE BURNHAM INSTITUTE (US) | 2003-02-27 | — | — | WO | disclosed |