Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837282 | 0.82 | HTR2A (0.57) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL5837782 | 0.81 | HTR2A (0.56) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL6740275 | 0.75 | SLC6A4 (0.74) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5837734 | 0.70 | HTR2A (0.52) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL2056277 | 0.68 | ALDH1A1 (0.50) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5836771 | 0.67 | HTR2A (0.54) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL12733355 | 0.66 | HTR2A (0.50) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5838544 | 0.65 | SLC6A4 (0.41) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5836773 | 0.65 | HTR2A (0.59) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL12732679 | 0.65 | NPBWR1 (0.39) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436938-B1 | ADMINISTERING A SIGMA RECEPTOR LIGAND IN COMBINATION WITH AN ANTIDEPRESSANT AGENT; ESPECIALLY FOR REFRACTORY DEPRESSION | PFIZER INC. | 2002-08-20 | — | — | US | claimed |
| US-20040162316-A1 | Combination treatment for alcoholism and alcohol dependence | PFIZER INC | 2004-08-19 | — | — | US | disclosed |
| US-20040048856-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | PFIZER INC | 2004-03-11 | — | — | US | disclosed |
| US-20040029972-A1 | Combination treatment for depression | HOWARD HARRY R (US) | 2004-02-12 | — | — | US | disclosed |
| US-20030130322-A1 | Biaryl ether derivative as opiod antagonist | PFIZER INC. | 2003-07-10 | — | — | US | disclosed |
| US-20020183306-A1 | Combination treatment for sleep disorders including sleep apnea | PFIZER INC. | 2002-12-05 | — | — | US | disclosed |
| US-20020165217-A1 | Combination treatment for anxiety and depression | PFIZER INC. | 2002-11-07 | — | — | US | disclosed |
| US-20020147206-A1 | Combination treatment of multiple sclerosis (MS), other demyelinating conditions and peripheral neuropathy, especially painful neuropathies and diabetic neuropathy | PFIZER INC. | 2002-10-10 | — | — | US | disclosed |
| US-20020143003-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | PFIZER INC. | 2002-10-03 | — | — | US | disclosed |
| US-20020123490-A1 | Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis | PFIZER INC. | 2002-09-05 | — | — | US | disclosed |
| US-20020107244-A1 | An antidepressant formulation consists of a biphenoxy or binaphthelenoxy compound as antidepressant, a 5-HT3 receptor antagonist and a carrier | PFIZER PRODUCTS INC. | 2002-08-08 | — | — | US | disclosed |
| US-20020099045-A1 | Combination treatment for depression | PFIZER PRODUCTS INC. | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130322-A1 | Biaryl ether derivative as opiod antagonist | OPRM1, OPRD1, OPRK1 | HTR2A 29/4885SLC6A4 40/4885KCNH2 2000/4885 |
| US-20020165217-A1 | Combination treatment for anxiety and depression | GABRA1, GABRA2, GABRA5 | HTR2A 48/4885SLC6A4 40/4885KCNH2 840/4885 |
| US-20020183306-A1 | Combination treatment for sleep disorders including sleep apnea | HTR1A, HTR2A, ADRA2A | HTR2A 2/4885SLC6A4 30/4885KCNH2 700/4885 |
| US-20020107244-A1 | An antidepressant formulation consists of a biphenoxy or binaphthelenoxy compound as antidepressant, a 5-HT3 receptor antagonist and a carrier | HTR3A, HTR3E, HTR4 | HTR2A 11/4885SLC6A4 19/4885KCNH2 2974/4885 |
| US-20040029972-A1 | Combination treatment for depression | HTR3A, HTR5A, HTR6 | HTR2A 9/4885SLC6A4 14/4885KCNH2 1815/4885 |
| US-20040162316-A1 | Combination treatment for alcoholism and alcohol dependence | OPRM1, SLC6A2, OPRK1 | HTR2A 43/4885SLC6A4 13/4885KCNH2 1285/4885 |
| US-20020123490-A1 | Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis | SLC6A3, OXTR, OPRD1 | HTR2A 13/4885SLC6A4 5/4885KCNH2 1532/4885 |
| US-20020099045-A1 | Combination treatment for depression | HTR5A, HTR1A, OPRL1 | HTR2A 4/4885SLC6A4 11/4885KCNH2 1516/4885 |
| US-20020147206-A1 | Combination treatment of multiple sclerosis (MS), other demyelinating conditions and peripheral neuropathy, especially painful neuropathies and diabetic neuropathy | PMP22, GAP43, SLC6A2 | HTR2A 108/4885SLC6A4 4/4885KCNH2 368/4885 |
| US-20020143003-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | SLC6A2, SLC6A4, SLC6A3 | HTR2A 24/4885SLC6A4 2/4885KCNH2 1224/4885 |
| US-20040048856-A1 | Monoamine reuptake inhibitors for treatment of CNS disorders | SLC6A2, SLC6A3, SLC18A2 | HTR2A 14/4885SLC6A4 4/4885KCNH2 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.