Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11290000 | 1.00 | CTSL (0.52) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL20583780 | 0.99 | CTSL (0.53) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL9437417 | 0.99 | CTSL (0.53) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Trifluoroacetic Acid SCHEMBL25383492 | 0.92 | CTSL (0.53) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Trifluoroacetic Acid SCHEMBL11275189 | 0.92 | CTSL (0.53) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7778325 | 0.92 | ALDH1A1 (0.52) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL8726231 | 0.92 | ALDH1A1 (0.52) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL3019477 | 0.92 | ALDH1A1 (0.52) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL11599047 | 0.91 | CTSL (0.50) | CTSLMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL8851538 | 0.90 | ALDH1A1 (0.53) | CTSLMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477912-B1 | Novel N-acyldipeptides, and pharmaceutical compositions containing the same | UNIV LJUBLJANI (SI) | 2001-08-29 | — | — | EP | disclosed |
| US-6008333-A | Preparation of glucosaminyl muramic acid derivatives | ENDOREX CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| US-5824652-A | IMMUNOSTIMULANTS, ANTITUMOR AGENTS | UNIVERZA V LJUBLJANI, FAKULTETA ZA NARAVOSLOVJE IN TECHNOLOGIJO, ODDELEK ZA FARMACIJO (SI) | 1998-10-20 | — | — | US | disclosed |
| EP-0695308-B1 | NOVEL HETEROCYCLIC ACYLDIPEPTIDES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UNIV LJUBLJANI (SI) | 1998-07-01 | — | — | EP | disclosed |
| US-5750665-A | Preparation of glucosaminyl muramic acid derivatives | ENDOREX CORPORATION | 1998-05-12 | — | — | US | disclosed |
| EP-0471280-B1 | Trans-2-acylaminocyclohexyloxyacyldipeptides | UNIV LJUBLJANI (YU) | 1996-11-06 | — | — | EP | disclosed |
| US-5514654-A | ANTITUMOR AGENTS AND IMMUNOMODULATORS | UNIV LJUBLJANI (SI) | 1996-05-07 | — | — | US | disclosed |
| EP-0695308-A1 | NOVEL HETEROCYCLIC ACYLDIPEPTIDES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UNIVERZA V LJUBLJANI, FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO, ODDELEK ZA FARMACIJO (SI) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024152-A1 | NOVEL HETEROCYCLIC ACYLDIPEPTIDES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UNIVERZA V LJUBLJANI, FAKULTETA ZA NARAVOSLOVJE IN TEHNOLOGIJO, ODDELEK ZA FARMACIJO (SI) | 1994-10-27 | — | — | WO | disclosed |
| US-5286715-A | Treating tumors | IMUNOLOSKI ZAVOD (CR) | 1994-02-15 | — | — | US | disclosed |
| US-4362716-A | IMMUNOSTIMULANTS | RHONE-POULENC INDUSTRIES (FR) | 1982-12-07 | — | — | US | disclosed |
| EP-0014159-B1 | IMMUNOLOGICALLY ACTIVE DIPEPTIDYL SACCHARIDES AND METHODS OF PREPARATION | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | disclosed |
| US-4310514-A | VACCINES | MERCK & CO., INC. (US) | 1982-01-12 | — | — | US | disclosed |
| EP-0041896-A1 | Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation | MERCK & CO. INC. (US) | 1981-12-16 | — | — | EP | disclosed |
| EP-0039637-A1 | Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation | MERCK & CO. INC. (US) | 1981-11-11 | — | — | EP | disclosed |
| US-4256735-A | BACTERICIDES | MERCK & CO., INC. (US) | 1981-03-17 | — | — | US | disclosed |
| EP-0018901-A1 | Immunologically active peptidyl disaccharides, methods of preparation and vaccine | MERCK & CO. INC. (US) | 1980-11-12 | — | — | EP | disclosed |
| EP-0014159-A1 | Immunologically active dipeptidyl saccharides and methods of preparation | MERCK & CO. INC. (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4101536-A | IMMUNOADJUVANT, ANTITUMOR | DAIICHI SEIYAKU CO., LTD. (JP) | 1978-07-18 | — | — | US | disclosed |
| US-4082735-A | NOVEL IMMUNOLOGICAL ADJUVANT COMPOUNDS AND METHODS OF PREPARATION THEREOF | SYNTEX (U.S.A.) INC. (US) | 1978-04-04 | — | — | US | disclosed |