Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.87 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.87 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.87 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.79 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.74 |
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.66 |
| ▸ | RXRA | P19793 | 4/20 | 0.64 |
| ▸ | RXRB | P28702 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | RXRG | P48443 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949143 | 0.98 | NR4A2 (0.90) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| Hydrochloric Acid SCHEMBL8544438 | 0.95 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL1756343 | 0.93 | NR4A2 (0.81) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL5582767 | 0.93 | NR4A2 (0.81) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL4059143 | 0.93 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL6830467 | 0.93 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL228477 | 0.93 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL11273693 | 0.91 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL11603952 | 0.91 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL11603274 | 0.91 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5202028-A | — | — | None | — | — | JP | disclosed |
| US-5891359-A | FLUOROTRIESTERAROMATIC COMPOUND FOR LIQUID CRYSTALS | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0465344-B1 | Liquid crystal compounds | SHOWA SHELL SEKIYU (JP) | 1996-09-04 | — | — | EP | disclosed |
| EP-0339987-B1 | Liquid crystal compounds having naphthalene nucleus | SHOWA SHELL SEKIYU (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5310500-A | Fluorinated naphthalenecarboxylic acid ester derivatives; electrooptics | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1994-05-10 | — | — | US | disclosed |
| US-5262086-A | Used as photoelectric element utilizing response to an electric field; exhibits high optical purity | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1993-11-16 | — | — | US | disclosed |
| JP-H05202028-A | OPTICALLY ACTIVE COMPOUND HAVING THIOPHENE RING | SHOWA SHELL SEKIYU KK | 1993-08-10 | — | — | JP | disclosed |
| US-5171471-A | Having wide range of phase transition temperatures for faster optical response times | SHOWA SHELL SEKIYU K.K. (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0465344-A1 | Liquid crystal compounds | Showa Shell Sekiyu Kabushiki Kaisha (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4973738-A | Liquid crystal compounds having naphthalene nucleus | SHOWA SHELL SEKIYU K.K. (JP) | 1990-11-27 | — | — | US | disclosed |
| EP-0339987-A2 | Liquid crystal compounds having naphthalene nucleus | Showa Shell Sekiyu Kabushiki Kaisha (JP) | 1989-11-02 | — | — | EP | disclosed |