SCHEMBL9102443

SCHEMBL9102443

CCCN(CCC)c1ncnc(NOCC(F)F)n1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 1/20 0.33
LMNA P02545 2/20 0.31
MAPT P10636 2/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfuric Acid SCHEMBL9106614 0.94 CRHR1 (0.30) CRHR1LMNAMAPTALDH1A1TP53
SCHEMBL9102501 0.80 CRHR1 (0.38) CRHR1LMNAMAPTALDH1A1TP53
SCHEMBL9106758 0.79 CRHR1 (0.35) CRHR1LMNAMAPTALDH1A1TP53
Hydrochloric Acid SCHEMBL9108148 0.79 CRHR1 (0.37) CRHR1LMNAMAPTALDH1A1TP53
SCHEMBL9104666 0.78 CRHR1 (0.36) CRHR1LMNAMAPT
Hydrochloric Acid SCHEMBL9106909 0.77 CRHR1 (0.35) CRHR1LMNAMAPT
SCHEMBL9107410 0.76 CRHR1 (0.39) CRHR1LMNAMAPTALDH1A1TP53
Sulfuric Acid SCHEMBL9109235 0.74 CRHR1 (0.32) CRHR1
SCHEMBL9107468 0.72 CRHR1 (0.38) CRHR1LMNAMAPTHTT
SCHEMBL9107263 0.66 MAPT (0.42) CRHR1LMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120142647-A1 Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases GALLEON PHARMACEUTICALS, INC. 2012-06-07 US claimed
US-20260137675-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT DRUG OVERDOSE ENALARE THERAPEUTICS INC (US) 2026-05-21 US disclosed
US-12544369-B2 Methods and pharmaceutical compositions to treat drug overdose ENALARE THERAPEUTICS INC. (US) 2026-02-10 US disclosed
US-20250325554-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT RESPIRATORY DEPRESSION IN PATIENTS ENALARE THERAPEUTICS INC (US) 2025-10-23 US disclosed
US-20250114370-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ENALARE THERAPEUTICS INC (US) 2025-04-10 US disclosed
US-20250032496-A1 METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT ENALARE THERAPEUTICS INC (US) 2025-01-30 US disclosed
US-12138267-B2 Methods of treating respiratory depression modulated by a non-opioid agent ENALARE THERAPEUTICS INC. (US) 2024-11-12 US disclosed
US-20240238303-A1 LARGE-CONDUCTANCE POTASSIUM CHANNEL MODULATORS, COMPOSITIONS THEREOF, METHODS OF MANUFACTURING THEREOF, AND METHODS OF USE THEREOF ENALARE THERAPEUTICS INC (US) 2024-07-18 US disclosed
US-20230414624-A1 METHODS OF TREATING NEUROLOGICAL VENTILATORY INSUFFICIENCY ENALARE THERAPEUTICS INC (US) 2023-12-28 US disclosed
WO-2023250141-A2 METHODS OF TREATING NEUROLOGICAL VENTILATORY INSUFFICIENCY ENALARE THERAPEUTICS INC. (US) 2023-12-28 WO disclosed
US-20230310440-A1 RESPIRATORY STIMULANT NASAL FORMULATIONS ENALARE THERAPEUTICS INC. 2023-10-05 US disclosed
US-20230210857-A1 RESPIRATORY STIMULANT PARENTERAL FORMULATIONS ENALARE THERAPEUTICS INC. 2023-07-06 US disclosed
WO-2023081185-A1 METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT ENALARE THERAPEUTICS INC. (US) 2023-05-11 WO disclosed
US-20230140606-A1 METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT ENALARE THERAPEUTICS INC. 2023-05-04 US disclosed
US-20220241268-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT DRUG OVERDOSE ENALARE THERAPEUTICS INC. 2022-08-04 US disclosed
CN-114173872-A Methods and pharmaceutical compositions for treating drug overdose 依那拉治疗股份有限公司 2022-03-11 CN disclosed
WO-2020236975-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT DRUG OVERDOSE PERGOLIZZI JOSEPH V (US) 2020-11-26 WO disclosed
US-20160256463-A1 NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES GALLEON PHARMACEUTICALS INC (US) 2016-09-08 US disclosed
US-9351972-B2 Compounds as respiratory stimulants for treatment of breathing control disorders or diseases GALLEON PHARMACEUTICALS, INC. (US) 2016-05-31 US disclosed
US-20120142647-A1 Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases GALLEON PHARMACEUTICALS, INC. 2012-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12544369-B2 Methods and pharmaceutical compositions to treat drug overdose OPRK1, OPRD1, OPRM1 CRHR1 87/4885LMNA 1240/4885MAPT 2846/4885
US-20120142647-A1 Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases MTNR1B, CHRM3, ADRA2C CRHR1 101/4885LMNA 2124/4885MAPT 3227/4885
US-12138267-B2 Methods of treating respiratory depression modulated by a non-opioid agent OPRK1, OPRM1, OPRD1 CRHR1 114/4885LMNA 3453/4885MAPT 3664/4885
US-20260137675-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT DRUG OVERDOSE ADRA2B, ADRB1, ADRB2 CRHR1 140/4885LMNA 499/4885MAPT 989/4885
US-20250325554-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT RESPIRATORY DEPRESSION IN PATIENTS NDUFB6, NDUFB7, CHRM5 CRHR1 204/4885LMNA 1470/4885MAPT 2509/4885
US-20250032496-A1 METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT OPRK1, OPRM1, OPRD1 CRHR1 114/4885LMNA 3453/4885MAPT 3664/4885
US-20230310440-A1 RESPIRATORY STIMULANT NASAL FORMULATIONS ADRA2C, MTNR1B, MTNR1A CRHR1 41/4885LMNA 3538/4885MAPT 4651/4885
US-20160256463-A1 NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES P2RX5, HRH2, ADRA2C CRHR1 184/4885LMNA 3628/4885MAPT 2741/4885
US-20230140606-A1 METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT OPRK1, OPRM1, OPRD1 CRHR1 114/4885LMNA 3453/4885MAPT 3664/4885
US-20220241268-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT DRUG OVERDOSE OPRK1, OPRM1, ADRB1 CRHR1 120/4885LMNA 390/4885MAPT 1346/4885
US-20250114370-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ADRA2A, ADRA2C, OPRM1 CRHR1 109/4885LMNA 566/4885MAPT 2796/4885
US-20240238303-A1 LARGE-CONDUCTANCE POTASSIUM CHANNEL MODULATORS, COMPOSITIONS THEREOF, METHODS OF MANUFACTURING THEREOF, AND METHODS OF USE THEREOF KCNN2, KCNN1, KCNN3 CRHR1 4067/4885LMNA 574/4885MAPT 4481/4885
US-20230210857-A1 RESPIRATORY STIMULANT PARENTERAL FORMULATIONS ADRA2C, ADRA1B, CHRM3 CRHR1 50/4885LMNA 3121/4885MAPT 4117/4885
US-20230414624-A1 METHODS OF TREATING NEUROLOGICAL VENTILATORY INSUFFICIENCY SDHA, NDUFB7, OTC CRHR1 1219/4885LMNA 1597/4885MAPT 2530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.