Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399223 | 0.97 | — | — | |
| Phenylhydrazine SCHEMBL28241394 | 0.84 | TDP1 (0.58) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL28320590 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7881442 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL250009 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5693995 | 0.74 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL2138441 | 0.74 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5693996 | 0.74 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| SCHEMBL193916 | 0.71 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| SCHEMBL8505294 | 0.71 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1TDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106831584-B | A kind of efficient method for preparing tri- substituted pyrazolecarboxylic class compound of 1,3,5- | 江西师范大学 | 2019-11-22 | — | — | CN | claimed |
| CN-107540627-A | One kind has Tuo hydrogen Cong Suan oxadiazine Hete rocyclic derivatives of antibacterial activity and its production and use | 南京林业大学 | 2018-01-05 | — | — | CN | claimed |
| CN-104478804-B | Double nitrogen-containing heterocycle compounds and its preparation method and application | 河南大学 | 2016-08-17 | — | — | CN | claimed |
| CN-104478804-A | Nitrogen-containing bisheterocyclic compound, and preparation method and application thereof | UNIV HENAN | 2015-04-01 | — | — | CN | claimed |
| CN-104098645-A | Ursolic acid indole derivative, preparation method and application thereof | UNIV NANJING FORESTRY | 2014-10-15 | — | — | CN | claimed |
| CN-102731404-B | Double-pyrazole ring compound and derivative, preparation method and application thereof | UNIV HENAN | 2014-06-11 | — | — | CN | claimed |
| CN-102731477-B | Pyrazoloquinoline compound and derivatives thereof, as well as preparation method and application thereof | UNIV HENAN | 2014-02-05 | — | — | CN | claimed |
| CN-102731404-A | Double-pyrazole ring compound and derivative, preparation method and application thereof | UNIV HENAN | 2012-10-17 | — | — | CN | claimed |
| CN-102731477-A | Pyrazoloquinoline compound and derivatives thereof, as well as preparation method and application of pyrazoloquinoline compound and derivatives thereof | UNIV HENAN | 2012-10-17 | — | — | CN | claimed |
| CN-101560153-A | 7,7,7-trifluoromethyl-6-carbonyl methyl heptanoate, 5-fluoro-2-trifluoromethyl-3-methyl indole butyrate and synthesis method thereof | UNIV SHANGHAI (CN) | 2009-10-21 | — | — | CN | claimed |
| JP-63152355-A | — | — | None | — | — | JP | disclosed |
| CN-107721982-B | A kind of antiobesity compounds and its preparation method and application | 中山大学 | 2019-12-03 | — | — | CN | disclosed |
| CN-106831584-B | A kind of efficient method for preparing tri- substituted pyrazolecarboxylic class compound of 1,3,5- | 江西师范大学 | 2019-11-22 | — | — | CN | disclosed |
| CN-110218161-A | A kind of preparation method aligning substituted phenylhydrazines hydrochloride | 河北民族师范学院 | 2019-09-10 | — | — | CN | disclosed |
| CN-106279153-B | Substituted benzazolyl compounds and its application method and purposes | 广东东阳光药业有限公司 | 2019-08-16 | — | — | CN | disclosed |
| EP-1080934-A1 | Ink-jet printing receiving sheet comprising gelatin and a metal salt | FERRANIA S.p.A. (IT) | 2001-03-07 | — | — | EP | disclosed |
| EP-1080935-A2 | Ink-jet print receiving sheet comprising a high-boiling organic solvent and an non-ionic surfactant | FERRANIA S.p.A. (IT) | 2001-03-07 | — | — | EP | disclosed |
| US-5897940-A | Ink jet transparencies | XEROX CORPORATION (US) | 1999-04-27 | — | — | US | disclosed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | disclosed |
| JP-S63152355-A | N'-(FLUOROPHENYL)BENZOHYDRAZIDE DERIVATIVE AND NON-MEDICAL MICROBICIDE | MEIJI SEIKA KAISHA LTD | 1988-06-24 | — | — | JP | disclosed |