Hydrochloric Acid

Hydrochloric Acid

SCHEMBL1160367

CCc1ccc(NN)cc1.Cl

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D known ✓ O15399 1/20 0.46
GRIN3B known ✓ O60391 1/20 0.46
GRIN1 known ✓ Q05586 1/20 0.46
GRIN2A known ✓ Q12879 1/20 0.46
GRIN2B known ✓ Q13224 1/20 0.46
GRIN2C known ✓ Q14957 1/20 0.46
GRIN3A known ✓ Q8TCU5 1/20 0.46
SIGMAR1 known ✓ Q99720 1/20 0.46
GAA known ✓ P10253 1/20 0.45
SRC known ✓ P12931 1/20 0.42
PTGS2 known ✓ P35354 1/20 0.42
CA2 known ✓ P00918 1/20 0.41
TAAR1 Q96RJ0 1/20 0.46
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
HPGD P15428 2/20 0.45
MEN1 O00255 1/20 0.45
APAF1 O14727 1/20 0.45
USP2 O75604 1/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1143908 0.97 TAAR1 (0.48) TAAR1RAB9AGRIN2DGRIN3BGRIN1
Bromide SCHEMBL20984809 0.95 TAAR1 (0.46) TAAR1RAB9AGRIN2DGRIN3BGRIN1
Hydrochloric Acid SCHEMBL31448117 0.88 SMN1; SMN2 (0.41) TAAR1RAB9AGRIN2DGRIN3BGRIN1
SCHEMBL31448008 0.85 SMN1; SMN2 (0.42) TAAR1RAB9AGRIN2DGRIN3BGRIN1
Oxalic Acid SCHEMBL20984103 0.85 ALDH1A1 (0.50) RAB9AGRIN2DGRIN3BGRIN1GRIN2A
Phosphoric Acid SCHEMBL20984608 0.85 SRC (0.58) RAB9AGRIN2DGRIN3BGRIN1GRIN2A
Sulfuric Acid SCHEMBL20984471 0.85 HPGD (0.50) RAB9AGRIN2DGRIN3BGRIN1GRIN2A
Nitric Acid SCHEMBL20984380 0.82 MAPT (0.46) RAB9AGRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL4294111 0.81 CA2 (0.45) TAAR1ALDH1A1POLBGAAIDO1
SCHEMBL1806848 0.78 CA2 (0.47) TAAR1ALDH1A1POLBGAAIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114276305-B Trisubstituted phenyl-1, 2, 4-triazole derivative, preparation method thereof and application thereof in treatment of neuronal injury 中山大学 2023-11-17 CN claimed
CN-114276305-A Tri-substituted phenyl-1, 2, 4-triazole derivative, preparation thereof and application thereof in treating neuronal injury 中山大学 2022-04-05 CN claimed
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2021-06-22 US claimed
CN-107663161-B Continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt 上海惠和化德生物科技有限公司 2020-04-10 CN claimed
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2019-05-23 US claimed
EP-0918052-B1 Improved polymeric mdi color BAYER AG (US) 2003-05-28 EP claimed
US-5942151-A PREVENTING THE DISCOLORATION OF PRODUCING POLYMETHYLENEPOLYPHENYLENE POLYISOCYANATE BY ADDING AN ADDITIVE HYDRAZINE OR A HYDRAZINE DERIVATIVE BAYER CORPORATION (US) 1999-08-24 US claimed
EP-0918052-A1 Improved polymeric mdi color Bayer Corporation (US) 1999-05-26 EP claimed
EP-3623372-B1 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS VALO HEALTH INC (US) 2026-02-04 EP disclosed
EP-3681877-B1 PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF HANMI PHARMACEUTICAL CO LTD (KR) 2024-10-16 EP disclosed
CN-115611823-B 1,2, 4-Triazole-phenyl hydroxamic acid compound, preparation method and application 新天地医药技术研究院(郑州)有限公司 2024-09-27 CN disclosed
CN-118561826-A 2, 3-Oxindole andrographolide derivative and preparation method and application thereof 郑州大学 2024-08-30 CN disclosed
WO-2024153134-A1 FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF 哈尔滨三联药业股份有限公司 2024-07-25 WO disclosed
CN-118359543-A Five-membered heterocyclic compound and medical application thereof 哈尔滨三联药业股份有限公司 2024-07-19 CN disclosed
WO-2007077961-A2 FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-07-12 WO disclosed
WO-2005040127-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2005-05-06 WO disclosed
US-20040043995-A1 Novel triazole derivatives, process for their preparation and pharmaceutical compositions containing them BIGNON ERIC (FR) 2004-03-04 US disclosed
EP-0918052-B1 Improved polymeric mdi color BAYER AG (US) 2003-05-28 EP disclosed
US-5942151-A PREVENTING THE DISCOLORATION OF PRODUCING POLYMETHYLENEPOLYPHENYLENE POLYISOCYANATE BY ADDING AN ADDITIVE HYDRAZINE OR A HYDRAZINE DERIVATIVE BAYER CORPORATION (US) 1999-08-24 US disclosed
EP-0918052-A1 Improved polymeric mdi color Bayer Corporation (US) 1999-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040043995-A1 Novel triazole derivatives, process for their preparation and pharmaceutical compositions containing them CCKAR, CCKBR, NPY1R GRIN2D 1604/4885GRIN3B 947/4885GRIN1 998/4885
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts HPD, TYR, PDK2 GRIN2D 3444/4885GRIN3B 4754/4885GRIN1 4283/4885
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts HPD, TYR, PDK2 GRIN2D 3444/4885GRIN3B 4754/4885GRIN1 4283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.