Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 known ✓ | P50406 | 2/20 | 0.50 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.48 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29392855 | 0.99 | KAT2B (0.59) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL111539 | 0.99 | KAT2B (0.59) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL10781769 | 0.89 | KAT2B (0.61) | KAT2BMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2472513 | 0.87 | KAT2B (0.60) | KAT2BMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL20420165 | 0.86 | MAPT (0.58) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL10580319 | 0.84 | MAPT (0.58) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL10576590 | 0.84 | LMNA (0.68) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL762553 | 0.84 | SMN1; SMN2 (0.60) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL16211097 | 0.83 | MAPT (0.57) | KAT2BMAPTLMNASMN1; SMN2TDP1 | |
| SCHEMBL739095 | 0.83 | MAPT (0.64) | KAT2BMAPTLMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034067-A1 | Hair colouring compositions | Unilever PLC (GB) | 2016-06-22 | — | — | EP | claimed |
| US-5972044-A | Composition and method for dyeing keratin fibers | WELLA AG (DE) | 1999-10-26 | — | — | US | claimed |
| EP-0867170-A2 | Composition and method for dyeing keratin fibres | Wella Aktiengesellschaft (DE) | 1998-09-30 | — | — | EP | claimed |
| EP-3229918-B1 | COMPOSITION AND PROCEDURE FOR TREATING KERATINIC FIBERS WITH FLASH EVAPORATION | HENKEL AG & CO KGAA (DE) | 2024-03-13 | — | — | EP | disclosed |
| US-11298304-B2 | Two component hair treatment kit comprising a hair coloring cream and a developer composition comprising a specific tensioactive compound | LABORATOIRE BIOSTHÉTIQUE KOSMETIK GMBH & CO. KG (DE) | 2022-04-12 | — | — | US | disclosed |
| US-20210128427-A1 | TWO COMPONENT HAIR TREATMENT KIT COMPRISING A HAIR COLORING CREAM AND A DEVELOPER COMPOSITION COMPRISING A SPECIFIC TENSIOACTIVE COMPOUND | LABORATOIRE BIOSTHÉTIQUE KOSMETIK GMBH & CO. KG (DE) | 2021-05-06 | — | — | US | disclosed |
| EP-3773435-A1 | TWO COMPONENT HAIR TREATMENT KIT COMPRISING A HAIR COLORING CREAM AND A DEVELOPER COMPOSITION COMPRISING A SPECIFIC TENSIOACTIVE COMPOUND | Laboratoire Biosthetique Kosmetik GmbH&Co. KG (DE) | 2021-02-17 | — | — | EP | disclosed |
| EP-2263642-B1 | Colouring bleaches | HENKEL AG & CO KGAA (DE) | 2020-04-15 | — | — | EP | disclosed |
| US-10456341-B2 | Compositions and methods for simultaneous reshaping and direct coloring of hair | ALFA PARF GROUP S.P.A. (IT) | 2019-10-29 | — | — | US | disclosed |
| EP-2930126-B1 | Fashionable aerosol dye | HENKEL AG & CO KGAA (DE) | 2019-10-09 | — | — | EP | disclosed |
| WO-2019185127-A1 | TWO COMPONENT HAIR TREATMENT KIT COMPRISING A HAIR COLORING CREAM AND A DEVELOPER COMPOSITION COMPRISING A SPECIFIC TENSIOACTIVE COMPOUND | HCT - HAIR COSMETIC TECHNOLOGY AG (CH) | 2019-10-03 | — | — | WO | disclosed |
| US-5972044-A | Composition and method for dyeing keratin fibers | WELLA AG (DE) | 1999-10-26 | — | — | US | disclosed |
| EP-0943316-A2 | Means for coloring and decoloring of hair | Wella Aktiengesellschaft (DE) | 1999-09-22 | — | — | EP | disclosed |
| EP-0898954-A2 | Composition for dyeing keratin fibres | Wella Aktiengesellschaft (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5865855-A | COUPLING TWO PYRAZOLE COMPOUNDS | WELLA AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| EP-0891971-A1 | Bispyrazole-aza compounds, processes for their preparation, and hair dyeing agents containing these compounds | Wella Aktiengesellschaft (DE) | 1999-01-20 | — | — | EP | disclosed |
| EP-0888768-A2 | Hair-dye | Wella Aktiengesellschaft (DE) | 1999-01-07 | — | — | EP | disclosed |
| EP-0867170-A2 | Composition and method for dyeing keratin fibres | Wella Aktiengesellschaft (DE) | 1998-09-30 | — | — | EP | disclosed |
| EP-0867171-A2 | Powder composition for the preparation of gels comprising a methyl hydroxyalkyl cellulose | Wella Aktiengesellschaft (DE) | 1998-09-30 | — | — | EP | disclosed |
| US-5026401-A | Hair dyes | L'OREAL (FR) | 1991-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128427-A1 | TWO COMPONENT HAIR TREATMENT KIT COMPRISING A HAIR COLORING CREAM AND A DEVELOPER COMPOSITION COMPRISING A SPECIFIC TENSIOACTIVE COMPOUND | KRT18, KIT, PRKDC | HTR6 2388/4885GLA 1785/4885GAA 4167/4885 |
| US-11298304-B2 | Two component hair treatment kit comprising a hair coloring cream and a developer composition comprising a specific tensioactive compound | KRT18, KIT, PRKDC | HTR6 2388/4885GLA 1785/4885GAA 4167/4885 |
| US-10456341-B2 | Compositions and methods for simultaneous reshaping and direct coloring of hair | GRHPR, DAO, ALPG | HTR6 1241/4885GLA 107/4885GAA 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.