Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.40 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.40 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.40 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.40 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.40 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.40 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.40 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.40 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.40 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.40 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.40 |
| ▸ | DPP4 known ✓ | P27487 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28925989 | 1.00 | GABRA1 (0.40) | GABRA1TSHRGABRG2GABRB3GABRB2 | |
| SCHEMBL1821813 | 0.98 | GABRA1 (0.41) | GABRA1TSHRGABRG2GABRB3GABRB2 | |
| Naphthoquinone SCHEMBL29639242 | 0.82 | DPP4 (0.44) | TSHRFAAHCA1CA2DPP4 | |
| Naphthoquinone SCHEMBL1820512 | 0.82 | DPP4 (0.44) | TSHRFAAHCA1CA2DPP4 | |
| Hydrochloric Acid SCHEMBL12478351 | 0.80 | GABRA1 (0.40) | GABRA1TSHRGABRG2GABRB3GABRB2 | |
| Hydrochloric Acid SCHEMBL2798765 | 0.80 | GABRA1 (0.40) | GABRA1TSHRGABRG2GABRB3GABRB2 | |
| SCHEMBL16267050 | 0.79 | GABRA1 (0.43) | GABRA1TSHRGABRG2GABRB3GABRB2 | |
| SCHEMBL1772757 | 0.79 | CYP3A4 (0.34) | TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL1822642 | 0.78 | ALDH1A1 (0.30) | TSHRALDH1A1ALOX15 | |
| SCHEMBL16655509 | 0.78 | DPP4 (0.45) | GABRA1TSHRGABRG2GABRB3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737301-B2 | Preparation of 2-bicyclopropyl-2-yl-phenylamine through catalyzing the dehydrochlorination in the presence of a palladium complex; cost efficiency; used as intermediates for the preparation of fungicides | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-15 | — | — | US | claimed |
| US-20090221855-A1 | PROCESS FOR THE PRODUCTION OF ANILINES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-03 | — | — | US | claimed |
| EP-1931618-B1 | PROCESS FOR THE PRODUCTION OF ANILINES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-05 | — | — | EP | claimed |
| EP-2560960-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| US-8524915-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-03 | — | — | US | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| US-8519151-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2316813-B1 | Process for the preparation of amines | SYNGENTA PARTICIPATIONS AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| US-20130041160-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130035495-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| EP-2316814-A1 | Process for preparation of halogen substituted benzonorbornenes derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316813-A1 | Process for the preparation of amines | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316809-A1 | Process for the preparation of benzonorbornane derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316815-A1 | Process for preparation of halogen substituted arynes | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| US-7781615-B2 | Process for the preparation of amines | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7737301-B2 | Preparation of 2-bicyclopropyl-2-yl-phenylamine through catalyzing the dehydrochlorination in the presence of a palladium complex; cost efficiency; used as intermediates for the preparation of fungicides | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090221855-A1 | PROCESS FOR THE PRODUCTION OF ANILINES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1931618-B1 | PROCESS FOR THE PRODUCTION OF ANILINES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221855-A1 | PROCESS FOR THE PRODUCTION OF ANILINES | CBR3, C1S, C9 | GABRA1 3973/4885GABRG2 4052/4885GABRB3 3192/4885 |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | F5, F12, F9 | GABRA1 2030/4885GABRG2 2199/4885GABRB3 2548/4885 |
| US-20130035495-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | F5, F7, F8 | GABRA1 1119/4885GABRG2 1357/4885GABRB3 1225/4885 |
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | HRH3, PAH, C1R | GABRA1 1065/4885GABRG2 2278/4885GABRB3 905/4885 |
| US-20130041160-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | CBR3, F12, CBR1 | GABRA1 1567/4885GABRG2 1096/4885GABRB3 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.