Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.39 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.35 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254403 | 0.97 | — | — | |
| Iodide SCHEMBL20524267 | 0.95 | TNF (0.46) | TNFLOXL2ALDH1A1CYP1A2CYP3A4 | |
| Iodomethane SCHEMBL28886765 | 0.91 | TNF (0.44) | TNFLOXL2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL24067260 | 0.84 | TNF (0.54) | TNFCYP3A4PIK3CAPIK3CGKMT2A | |
| Pyridine SCHEMBL637184 | 0.79 | KMT2A (0.43) | TNFALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2154504 | 0.78 | KMT2A (0.47) | TNFLOXL2CYP1A2KMT2AKDM4E | |
| SCHEMBL13907293 | 0.76 | LOXL2 (0.50) | LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL4699655 | 0.74 | ENPP2 (0.47) | LOXL2ALDH1A1CYP1A2CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL28747248 | 0.74 | ENPP2 (0.47) | LOXL2ALDH1A1CYP1A2CYP3A4KMT2A | |
| SCHEMBL254617 | 0.73 | MEN1 (0.52) | LOXL2ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215841-B | Pyridinium-coumarin derivative fluorescent probe and preparation method and application thereof | 河南理工大学 | 2024-01-23 | — | — | CN | claimed |
| CN-117003781-A | Coumarin derivative fluorescent probe and preparation method and application thereof | 河南理工大学 | 2023-11-07 | — | — | CN | claimed |
| CN-114605318-B | Perchlorate visual fluorescent probe molecule and preparation method thereof | 中国科学院新疆理化技术研究所 | 2023-07-07 | — | — | CN | claimed |
| CN-115215841-A | Pyridinium-coumarin derivative fluorescent probe and preparation method and application thereof | 河南理工大学 | 2022-10-21 | — | — | CN | claimed |
| CN-111484447-B | Bipyridyl ligand and preparation method thereof, ruthenium supermolecule self-assembly containing bipyridyl ligand and preparation method and application thereof | 江苏师范大学 | 2022-09-02 | — | — | CN | claimed |
| CN-113773245-B | Water-soluble double-targeting near-infrared fluorescent probe and preparation method thereof | 西安交通大学口腔医院 | 2022-07-01 | — | — | CN | claimed |
| CN-114605318-A | Perchlorate visual fluorescent probe molecule and preparation method thereof | 中国科学院新疆理化技术研究所 | 2022-06-10 | — | — | CN | claimed |
| CN-113773245-A | Water-soluble double-targeting near-infrared fluorescent probe and preparation method thereof | 西安交通大学口腔医院 | 2021-12-10 | — | — | CN | claimed |
| CN-111484447-A | Bipyridyl ligand and preparation method thereof, ruthenium supermolecule self-assembly containing bipyridyl ligand and preparation method and application thereof | 江苏师范大学 | 2020-08-04 | — | — | CN | claimed |
| CN-107417598-B | Fluorescent probe for detecting G-quadruplex DNAs (deoxyribonucleic acids) and preparation method thereof | 山西大学 | 2020-04-17 | — | — | CN | claimed |
| CN-107501170-B | A kind of adjustable aggregation-induced emission type fluorescent material of spectrum and its preparation method and application | 陕西师范大学 | 2019-08-20 | — | — | CN | claimed |
| CN-107501170-A | A kind of adjustable aggregation-induced emission type fluorescent material of spectrum and its preparation method and application | 陕西师范大学 | 2017-12-22 | — | — | CN | claimed |
| CN-107417598-A | Fluorescence probe available for the serobila DNAs of G tetra- detections and preparation method thereof | 山西大学 | 2017-12-01 | — | — | CN | claimed |
| US-20250084087-A1 | BICYCLIC HETEROCYCLES AS MRGPRX2 ANTAGONISTS | INCYTE CORPORATION | 2025-03-13 | — | — | US | disclosed |
| WO-2025042730-A1 | BICYCLIC HETEROCYCLES AS MRGPRX2 ANTAGONISTS | INCYTE CORPORATION (US) | 2025-02-27 | — | — | WO | disclosed |
| US-20240208815-A1 | PORPHYRAZINES AS EFFICIENT, CATALYTIC AND SCALABLE METHOD TO PRODUCE CHLORINE DIOXIDE | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2024-06-27 | — | — | US | disclosed |
| US-5364860-A | Naphthyridine compounds which inhibit tyrosine kinase and their pharmaceutical compositions | LABORATOIRES UPSA (FR) | 1994-11-15 | — | — | US | disclosed |
| EP-0527181-A4 | HETEROCYCLICETHENEDIYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE | — | 1993-04-07 | — | — | EP | disclosed |
| EP-0527181-A1 | HETEROCYCLICETHENEDIYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1993-02-17 | — | — | EP | disclosed |
| WO-1991016305-A1 | HETEROCYCLICETHENEDIYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250084087-A1 | BICYCLIC HETEROCYCLES AS MRGPRX2 ANTAGONISTS | MRGPRX2, MRGPRX1, MRGPRX4 | PIK3CA 2862/4885HRH1 294/4885HDAC8 2182/4885 |
| US-20240208815-A1 | PORPHYRAZINES AS EFFICIENT, CATALYTIC AND SCALABLE METHOD TO PRODUCE CHLORINE DIOXIDE | PPOX, FECH, CAT | PIK3CA 3092/4885HRH1 2379/4885HDAC8 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.