Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.39 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36267 | 0.98 | MMP1 (0.40) | MMP1MMP2MMP3MMP9EPHX1 | |
| Chloromethane SCHEMBL4631102 | 0.94 | MMP1 (0.38) | MMP1MMP2MMP3MMP9EPHX1 | |
| Acetone SCHEMBL10451495 | 0.94 | MCL1 (0.39) | MMP1MMP2MMP3MMP9EPHX1 | |
| Sulfuric Acid SCHEMBL2065285 | 0.90 | EPHX1 (0.38) | MMP1MMP2MMP3MMP9EPHX1 | |
| Acrylamide SCHEMBL11143542 | 0.87 | ALDH1A1 (0.39) | MMP1MMP2MMP3MMP9EPHX1 | |
| SCHEMBL994218 | 0.85 | EPHX1 (0.47) | MMP2EPHX1PLA2G4ADPP7 | |
| SCHEMBL7129427 | 0.84 | MMP1 (0.40) | MMP1MMP2MMP3MMP9EPHX1 | |
| SCHEMBL6933418 | 0.84 | PLA2G4A (0.32) | MMP1MMP2MMP3MMP9EPHX1 | |
| SCHEMBL2066063 | 0.84 | EPHX1 (0.34) | MMP1MMP2MMP3MMP9EPHX1 | |
| SCHEMBL1067451 | 0.83 | EPHX1 (0.52) | EPHX1PLA2G4ADPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109441-B1 | POLYSILOXANE BLOCK COPOLYMERS | BASF SE (DE) | 2016-01-27 | — | — | EP | claimed |
| US-8378038-B2 | Polysiloxane block copolymers | BASF SE (DE) | 2013-02-19 | — | — | US | claimed |
| US-20100303750-A1 | POLYSILOXANE BLOCK COPOLYMERS | KOROSKENYI BALINT | 2010-12-02 | — | — | US | claimed |
| EP-2109441-A2 | POLYSILOXANE BLOCK COPOLYMERS | Ciba Holding Inc. (CH) | 2009-10-21 | — | — | EP | claimed |
| US-20080199418-A1 | Polysiloxane block copolymers | BASF SE (DE) | 2008-08-21 | — | — | US | claimed |
| WO-2008095822-A2 | POLYSILOXANE BLOCK COPOLYMERS | CIBA HOLDING INC. (CH) | 2008-08-14 | — | — | WO | claimed |
| EP-3116919-B1 | NEW POLYELECTROLYTIC POLYMERS, PROCESS FOR THEIR PREPARATION AND USES THEREOF | ITALMATCH CHEMICALS SPA (IT) | 2020-08-26 | — | — | EP | disclosed |
| US-9771437-B2 | Polyelectrolytic polymers, process for their preparation and uses thereof | ITALMATCH CHEMICALS S.P.A. (IT) | 2017-09-26 | — | — | US | disclosed |
| US-20170107310-A1 | New polyelectrolytic polymers, process for their preparation and uses thereof | ITALMATCH CHEMICALS S.P.A. (IT) | 2017-04-20 | — | — | US | disclosed |
| EP-3116919-A1 | NEW POLYELECTROLYTIC POLYMERS, PROCESS FOR THEIR PREPARATION AND USES THEREOF | Italmatch Chemicals S.P.A. (IT) | 2017-01-18 | — | — | EP | disclosed |
| EP-2109441-B1 | POLYSILOXANE BLOCK COPOLYMERS | BASF SE (DE) | 2016-01-27 | — | — | EP | disclosed |
| WO-2015136438-A1 | NEW POLYELECTROLYTIC POLYMERS, PROCESS FOR THEIR PREPARATION AND USES THEREOF | G.R.S. CHEMICAL TECHNOLOGIES S.R.L. (IT) | 2015-09-17 | — | — | WO | disclosed |
| US-8378038-B2 | Polysiloxane block copolymers | BASF SE (DE) | 2013-02-19 | — | — | US | disclosed |
| US-20050261394-A1 | Polymers for paper and paperboard coatings | CIBA SPECIALTY CHEMICALS WATER TREATMENT LIMITED (GB) | 2005-11-24 | — | — | US | disclosed |
| US-20050224420-A1 | Enhanced recovery of useful coal, potassium chloride and borax from screen bowl centrifuge | ECOLAB USA INC. | 2005-10-13 | — | — | US | disclosed |
| EP-1363957-A4 | CATIONIC LATEX TERPOLYMERS FOR SLUDGE DEWATERING | ONDEO NALCO CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1363957-A1 | CATIONIC LATEX TERPOLYMERS FOR SLUDGE DEWATERING | Ondeo Nalco Company (US) | 2003-11-26 | — | — | EP | disclosed |
| US-6627719-B2 | Interpolymer of a cationic monomer, a hydroxyalkyl (meth)acrylate and, optionally, a nonionic monomer | ONDEO NALCO COMPANY | 2003-09-30 | — | — | US | disclosed |
| US-20030060586-A1 | Cationic latex terpolymers for sludge dewatering | ECOLAB USA INC. | 2003-03-27 | — | — | US | disclosed |
| WO-2002060967-A1 | CATIONIC LATEX TERPOLYMERS FOR SLUDGE DEWATERING | ONDEO NALCO COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107310-A1 | New polyelectrolytic polymers, process for their preparation and uses thereof | PARG, PARN, PCBP1 | MMP1 4468/4885GAA 1373/4885DPP4 4740/4885 |
| US-20100303750-A1 | POLYSILOXANE BLOCK COPOLYMERS | KRT18, PUF60, SCNN1B | MMP1 1659/4885GAA 3724/4885DPP4 4155/4885 |
| US-20080199418-A1 | Polysiloxane block copolymers | KRT18, PUF60, SCNN1B | MMP1 1659/4885GAA 3724/4885DPP4 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.