Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6357770 | 0.98 | DNM1 (0.52) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL10730965 | 0.82 | DNM1 (0.53) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL793323 | 0.80 | DNM1 (0.52) | DNM1KDM4EALDH1A1MEN1HTT | |
| SCHEMBL78355 | 0.79 | KDM4E (0.59) | DNM1KDM4EALDH1A1MEN1HTT | |
| SCHEMBL36169 | 0.79 | DNM1 (0.55) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL6673670 | 0.78 | DNM1 (0.50) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL31665910 | 0.78 | DNM1 (0.50) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL6674841 | 0.78 | DNM1 (0.50) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL10949036 | 0.78 | DNM1 (0.42) | DNM1KDM4EALDH1A1MEN1HTT | |
| Hydrochloric Acid SCHEMBL28262890 | 0.78 | DNM1 (0.50) | DNM1KDM4EALDH1A1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129221-B1 | POLYMORPHS OF 3-(E)-2-{2-[6-(2-CYANOPHENOXY) PYRIMIDIN-4-YLOXY]PHENYL}-3-METHOXYACRYLATE | ADAMA MAKHTESHIM LTD (IL) | 2018-01-03 | — | — | EP | disclosed |
| US-20150057152-A1 | POLYMORPHS OF METHYL 3-(E)-2--3-METHOXYACRYLATE | MAKHTESHIM CHEMICAL WORKS INC (IL) | 2015-02-26 | — | — | US | disclosed |
| US-8877767-B2 | Polymorphs of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phyenyl}-3-methoxyacrylate | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2014-11-04 | — | — | US | disclosed |
| US-8648203-B2 | Process for preparing pyridinamines and novel polymorphs thereof | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2014-02-11 | — | — | US | disclosed |
| US-20140018378-A1 | POLYMORPHS OF METHYL (E)-2--3-METHOXYACRYLATE | MAKHTESHIM CHEMICAL WORKS, INC. (IL) | 2014-01-16 | — | — | US | disclosed |
| US-8546411-B2 | Polymorphs of methyl (E)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy] phenyl}-3-methoxyacrylate | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2013-10-01 | — | — | US | disclosed |
| US-8524723-B2 | Polymorphs of methyl 3-(E)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy] phenyl}-3-methoxyacrylate | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2013-09-03 | — | — | US | disclosed |
| US-20130158054-A1 | POLYMORPHS OF 3-(E)-2--3-METHOXYACRYLATE | MAKHTESHIM CHEMICAL WORKS, INC. (IL) | 2013-06-20 | — | — | US | disclosed |
| US-20120197023-A1 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2012-08-02 | — | — | US | disclosed |
| US-8163930-B2 | Process for preparing pyridinamines and novel polymorphs thereof | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2012-04-24 | — | — | US | disclosed |
| EP-1954271-A2 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF | MAKHTESHIM CHEMICAL WORKS LIMITED (IL) | 2008-08-13 | — | — | EP | disclosed |
| WO-2008093325-A2 | POLYMORPHS OF 3-(E)-2-{2-[6-(2-CYANOPHENOXY) PYRIMIDIN-4-YLOXY]PHENYL}-3-METHOXYACRYLATE | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2008-08-07 | — | — | WO | disclosed |
| WO-2007060662-A2 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF | MAKHTESHIM CHEMICAL WORKS LTD. (IL) | 2007-05-31 | — | — | WO | disclosed |
| EP-0049111-B1 | PHENOXYBUTYLTRIAZOLE COMPOUND, AGRICULTURAL AND HORTICULTURAL FUNGICIDAL COMPOSITION CONTAINING THE SAME, AND PROCESS FOR PRODUCING THE SAME | ISHIHARA SANGYO KAISHA LTD. (JP) | 1984-08-29 | — | — | EP | disclosed |
| EP-0031257-B1 | PYRIDYLANILINES | ISHIHARA SANGYO KAISHA LTD. (JP) | 1984-08-15 | — | — | EP | disclosed |
| US-4399143-A | Phenoxybutyltriazole compound, agricultural and horticultural fungicidal composition containing the same, and process for producing the same | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1983-08-16 | — | — | US | disclosed |
| US-4378367-A | INSECTICIDES; PESTICIDES; PROTECT-IVE COATINGS | FBC LIMITED (GB) | 1983-03-29 | — | — | US | disclosed |
| US-4331670-A | PESTICIDES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1982-05-25 | — | — | US | disclosed |
| EP-0049111-A1 | Phenoxybutyltriazole compound, agricultural and horticultural fungicidal composition containing the same, and process for producing the same | ISHIHARA SANGYO KAISHA LTD. (JP) | 1982-04-07 | — | — | EP | disclosed |
| EP-0031257-A2 | Pyridylanilines | ISHIHARA SANGYO KAISHA LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120197023-A1 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF | PDXK, FN3KRP, PTMS | DNM1 1778/4885KDM4E 775/4885ALDH1A1 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.