Hydrochloric Acid

Hydrochloric Acid

SCHEMBL219905

CC(C)(C)OC(=O)NCCN.Cl

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 1/20 0.53
MAOA known ✓ P21397 1/20 0.53
MAOB known ✓ P27338 1/20 0.53
CA2 known ✓ P00918 8/20 0.46
TDP1 Q9NUW8 1/20 0.56
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
CA1 P00915 8/20 0.46
CA12 O43570 7/20 0.46
CA9 Q16790 7/20 0.46
EPHX1 P07099 1/20 0.46
HTT P42858 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALDH1A1 P00352 1/20 0.41
GFER P55789 1/20 0.41
MALT1 Q9UDY8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34362 0.98 TDP1 (0.58) TDP1MEN1GAAKMT2AMAOA
Ammonia Solution, Strong SCHEMBL28173213 0.96 TDP1 (0.56) TDP1MEN1GAAKMT2AMAOA
Bicarbonate SCHEMBL4130667 0.94 MEN1 (0.56) TDP1MEN1GAAKMT2AMAOA
Acetic Acid SCHEMBL8853938 0.92 MEN1 (0.54) TDP1MEN1GAAKMT2AMAOA
SCHEMBL31574412 0.90 MEN1 (0.53) TDP1MEN1GAAKMT2AMAOA
Hydrochloric Acid SCHEMBL5199631 0.89 MAOA (0.55) TDP1MEN1GAAKMT2AMAOA
Hydrochloric Acid SCHEMBL6512546 0.89 MAOA (0.55) TDP1MEN1GAAKMT2AMAOA
Hydrochloric Acid SCHEMBL5973450 0.88 TDP1 (0.62) TDP1MEN1GAAKMT2AMAOA
SCHEMBL1307836 0.86 MAOA (0.57) TDP1MEN1GAAKMT2AMAOA
SCHEMBL6384884 0.86 MAOA (0.57) TDP1MEN1GAAKMT2AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114748642-A Tetravalent platinum drug-polymer conjugate nano micelle and preparation method and application thereof 江西本草天工科技有限责任公司 2022-07-15 CN claimed
CN-122070279-A Fibroblast activation protein inhibitor 苏州博锐创合医药有限公司 2026-05-19 CN disclosed
US-20260091081-A1 A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-04-02 US disclosed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US disclosed
EP-4596535-A1 DRUG FOR TREATING HUMAN TUMOR BY ERF3A TARGETED PROTEIN DEGRADATION MECHANISM Suzhou Degen Bio-Medical Co, Ltd. (CN) 2025-08-06 EP disclosed
US-20250213701-A1 MEDICAMENT FOR TREATING HUMAN TUMOR BASED ON ERF3A-TARGETING PROTEOLYSIS MECHANISM SUZHOU DEGEN BIO-MEDICAL CO., LTD. (CN) 2025-07-03 US disclosed
CN-119684336-A Bisubstituted tribranched fluoroborodipyrrole compound containing active functional group, preparation method thereof and nucleophilic substitution product 南京航空航天大学 2025-03-25 CN disclosed
WO-2025026226-A1 POLYETHYLENE GLYCOL SMALL MOLECULE DRUG, PREPARATION METHOD THEREFOR AND USE THEREOF 重庆阿普格雷生物科技有限公司 2025-02-06 WO disclosed
CN-115926177-B Polymer, polymer micelle, and preparation method and application thereof 四川大学 2024-11-08 CN disclosed
EP-3978472-B1 BIARYL MONABACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS MERCK SHARP & DOHME LLC (US) 2024-10-16 EP disclosed
US-20070197465-A1 Hyaluronic Acid-Methotrexate Conjugate DENKI KAGAKU KABUSHIKI KAISHA (JP) 2007-08-23 US disclosed
CN-1953965-A Novel cis-imidazolines HOFFMANN LA ROCHE (CH) 2007-04-25 CN disclosed
US-20070054304-A1 COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES INVITROGEN CORPORATION (US) 2007-03-08 US disclosed
EP-1739097-A1 HYALURONIC ACID/METHOTREXATE COMPOUND DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2007-01-03 EP disclosed
EP-1724287-A1 HYALURONIC ACID/METHOTREXATE COMPOUND DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2006-11-22 EP disclosed
US-20050288287-A1 Chiral cis-imidazolines FOTOUHI NADER 2005-12-29 US disclosed
US-20050191643-A1 Non-fluorescent carbocyanine quencher, molecular biology, immunology and fluorescence-based assays MOLECULAR PROBES, INC. 2005-09-01 US disclosed
WO-2005047901-A2 COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION PHOSPHORYLATED MOLECULES MOLECULAR PROBES, INC. (US) 2005-05-26 WO disclosed
US-20050014197-A1 Compositions and methods for detection and isolation of phosphorylated molecules MOLECULAR PROBES, INC. 2005-01-20 US disclosed
US-20040171034-A1 Compositions and methods for detection and isolation of phosphorylated molecules MOLECULAR PROBES, INC. 2004-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050191643-A1 Non-fluorescent carbocyanine quencher, molecular biology, immunology and fluorescence-based assays IDO1, IDO2, INMT GAA 4262/4885MAOA 2903/4885MAOB 2052/4885
US-20070197465-A1 Hyaluronic Acid-Methotrexate Conjugate CD44, MTX1, MTX2 GAA 1806/4885MAOA 2327/4885MAOB 2928/4885
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule CD4, TAP1, MCTS1 GAA 3324/4885MAOA 4814/4885MAOB 4830/4885
US-20250213701-A1 MEDICAMENT FOR TREATING HUMAN TUMOR BASED ON ERF3A-TARGETING PROTEOLYSIS MECHANISM XIAP, TP53, UBE3A GAA 940/4885MAOA 3426/4885MAOB 2383/4885
US-20260091081-A1 A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE CD4, MALT1, LY6K GAA 3674/4885MAOA 4469/4885MAOB 4493/4885
US-20050288287-A1 Chiral cis-imidazolines TP53, MDM2, TP53BP1 GAA 3520/4885MAOA 4802/4885MAOB 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.