Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 known ✓ | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG known ✓ | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 known ✓ | P11230 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.32 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | CHRND known ✓ | Q07001 | 1/20 | 0.32 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.31 |
| ▸ | HTR7 known ✓ | P34969 | 2/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233262 | 0.99 | DHFR (0.35) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7645646 | 0.81 | MTNR1A (0.35) | DHFRMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL29702380 | 0.78 | BRD4 (0.31) | MAPTALDH1A1HTTNPSR1 | |
| Hydrochloric Acid SCHEMBL2236336 | 0.75 | ALDH1A1 (0.34) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8204448 | 0.74 | DHFR (0.34) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8194753 | 0.74 | GPR3 (0.31) | — | |
| SCHEMBL2232977 | 0.73 | ALDH1A1 (0.35) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7252933 | 0.73 | ALDH1A1 (0.38) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7996886 | 0.73 | ALDH1A1 (0.38) | DHFRMAPTNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6434708 | 0.73 | GPR3 (0.40) | POLBSLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799726-B1 | TRIALKYLALUMINUM TREATED SUPPORTS | EXXONMOBIL CHEM PATENTS INC (US) | 2011-07-13 | — | — | EP | claimed |
| US-20070055028-A1 | Preparation of polymerization catalyst activators utilizing indole-modified silica supports | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-03-08 | — | — | US | claimed |
| US-20060079394-A1 | Trialkylaluminum treated supports | EXXONMOBIL CHEMICAL PATENTS INC. | 2006-04-13 | — | — | US | claimed |
| US-20050148743-A1 | polymerization catalyst systems comprising an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound | EXXONMOBIL CHEMICAL PATENTS INC. | 2005-07-07 | — | — | US | claimed |
| US-7741417-B2 | Preparation of polymerization catalyst activators utilizing indole-modified silica supports | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-7385015-B2 | Trialkylaluminum treated supports | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-20070055028-A1 | Preparation of polymerization catalyst activators utilizing indole-modified silica supports | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-03-08 | — | — | US | disclosed |
| US-20060079394-A1 | Trialkylaluminum treated supports | EXXONMOBIL CHEMICAL PATENTS INC. | 2006-04-13 | — | — | US | disclosed |
| EP-0991676-B1 | MULTISTAGE POLYMERIZATION PROCESS USING A CATALYST HAVING DIFFERENT CATALYTICALLY ACTIVE SITES | BOREALIS TECH OY (FI) | 2005-08-31 | — | — | EP | disclosed |
| US-20050148743-A1 | polymerization catalyst systems comprising an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound | EXXONMOBIL CHEMICAL PATENTS INC. | 2005-07-07 | — | — | US | disclosed |
| US-6545105-B1 | Multi-site polymerization catalyst comprises at least two eta-liganded catalysts, each of which comprises a complex of zirconium, hafnium or titanium, especially a metallocene catalyst. | BOREALIS A/S (DK) | 2003-04-08 | — | — | US | disclosed |
| US-6506858-B1 | Alkylating catalyst support; treating with guanidine derivative procatalyst and activator | BOREALIS A/S (DK) | 2003-01-14 | — | — | US | disclosed |