Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pargeverine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.46 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.46 |
| ▸ | CHRM4 known ✓ | P08173 | 3/20 | 0.44 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.44 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.41 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.41 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pargeverine SCHEMBL2111437 | 0.99 | CYP3A4 (0.51) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Dimenoxadol SCHEMBL79044 | 0.85 | CYP3A4 (0.70) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Dimenoxadol SCHEMBL2886211 | 0.85 | CYP3A4 (0.70) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Dimenoxadol SCHEMBL5854258 | 0.84 | CYP3A4 (0.69) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Dimenoxadol SCHEMBL25993 | 0.84 | CYP3A4 (0.68) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Dimenoxadol SCHEMBL2204879 | 0.83 | CYP3A4 (0.67) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Denaverine SCHEMBL9569397 | 0.80 | CYP3A4 (0.54) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Denaverine SCHEMBL147346 | 0.79 | CYP3A4 (0.52) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL9047935 | 0.76 | POLB (0.74) | CYP3A4CYP2D6POLBALDH1A1CHRM2 | |
| SCHEMBL8134540 | 0.75 | ALDH1A1 (0.50) | CYP3A4CYP2D6POLBALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118860991-B | Data processing method, device, equipment and storage medium | 中移动信息技术有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-119150313-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118860991-A | Data processing method, device, equipment and storage medium | 中移动信息技术有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118840115-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118841015-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118826932-A | Probe configuration method, device, equipment and storage medium | 中国移动通信集团陕西有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-118802331-A | Data processing method, device, equipment and storage medium | 中国移动通信集团陕西有限公司 | 2024-10-18 | — | — | CN | disclosed |
| CN-118656298-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-118193040-A | Data processing method, system, device, equipment and storage medium | 中国银联股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-118118169-A | Digital certificate management method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-118096305-A | Order settlement method, system, device, equipment and storage medium | 中国银联股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117764754-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-117557370-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117539670-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-117521145-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117495449-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116993349-A | Data processing method, device, equipment and storage medium | 中国银联股份有限公司 | 2023-11-03 | — | — | CN | disclosed |