Dimenoxadol

Dimenoxadol

SCHEMBL79044

CCOC(C(=O)OCCN(C)C)(c1ccccc1)c1ccccc1.Cl

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Dimenoxadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 5/20 0.52
CHRM1 known ✓ P11229 5/20 0.52
CHRM3 known ✓ P20309 5/20 0.52
GAA known ✓ P10253 1/20 0.51
CHRM4 known ✓ P08173 3/20 0.50
CHRM5 known ✓ P08912 1/20 0.50
SCN1A known ✓ P35498 1/20 0.47
SCN2A known ✓ Q99250 1/20 0.47
SIGMAR1 known ✓ Q99720 1/20 0.47
SCN3A known ✓ Q9NY46 1/20 0.47
DRD2 known ✓ P14416 1/20 0.44
OPRM1 known ✓ P35372 1/20 0.44
DRD3 known ✓ P35462 1/20 0.44
CYP3A4 P08684 3/20 0.70
CYP2D6 P10635 3/20 0.70
LMNA P02545 3/20 0.57
POLB P06746 3/20 0.54
ALDH1A1 P00352 1/20 0.53
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimenoxadol SCHEMBL2886211 1.00 CYP3A4 (0.70) CYP3A4CYP2D6LMNAPOLBALDH1A1
Dimenoxadol SCHEMBL5854258 0.99 CYP3A4 (0.69) CYP3A4CYP2D6LMNAPOLBALDH1A1
Dimenoxadol SCHEMBL25993 0.99 CYP3A4 (0.68) CYP3A4CYP2D6LMNAPOLBALDH1A1
Dimenoxadol SCHEMBL2204879 0.97 CYP3A4 (0.67) CYP3A4CYP2D6LMNAPOLBALDH1A1
Dimenoxadol SCHEMBL4580231 0.87 CYP3A4 (0.55) CYP3A4CYP2D6LMNAPOLBALDH1A1
Denaverine SCHEMBL9569397 0.86 CYP3A4 (0.54) CYP3A4CYP2D6LMNAPOLBALDH1A1
Pargeverine SCHEMBL30728632 0.85 CYP3A4 (0.53) CYP3A4CYP2D6LMNAPOLBALDH1A1
Denaverine SCHEMBL147346 0.84 CYP3A4 (0.52) CYP3A4CYP2D6LMNAPOLBALDH1A1
Pargeverine SCHEMBL2111437 0.84 CYP3A4 (0.51) CYP3A4CYP2D6LMNAPOLBALDH1A1
SCHEMBL27585378 0.82 CYP3A4 (0.63) CYP3A4CYP2D6LMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858887-B2 Linker compounds, methods of producing the same and uses thereof SHENKAR COLLEGE OF ENGINEERING AND DESIGN (IL) 2024-01-02 US claimed
JP-1056660-A None JP disclosed
US-20260092051-A1 PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CANCERS INCLUDING THE SAME HANMI PHARMACEUTICAL CO LTD (KR) 2026-04-02 US disclosed
US-12522684-B2 Active-energy-ray-curable resin composition and cured product thereof NIPPON SHOKUBAI CO., LTD. (JP) 2026-01-13 US disclosed
US-20260007779-A1 CT CONTRAST AGENT FOR DETECTION OF CACHEXIA UNIV GENEVE (CH) 2026-01-08 US disclosed
EP-4674238-A1 HOLE-SELECTIVE CONTACT MATERIAL, PHOTOELECTRIC CONVERSION DEVICE AND POLYCYCLIC AROMATIC HYDROCARBON COMPOUND Okinawa Institute of Science and Technology School Corporation (JP) 2026-01-07 EP disclosed
EP-4660176-A1 N-HETEROCYCLIC COMPOUNDS USED AS NITRIFICATION INHIBITOR EuroChem Antwerpen (BE) 2025-12-10 EP disclosed
EP-4159779-B1 ACTIVE-ENERGY-RAY-CURABLE RESIN COMPOSITION AND CURED PRODUCT THEREOF NIPPON CATALYTIC CHEM IND (JP) 2025-12-10 EP disclosed
US-20250367307-A1 PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND/OR PREVENTION TORAY INDUSTRIES, INC. (JP) 2025-12-04 US disclosed
EP-4630122-A1 METHODS FOR TREATING PATIENTS WITH HEMATOLOGIC MALIGNANCIES Aptose Biosciences Inc. (CA) 2025-10-15 EP disclosed
EP-0713134-B1 Processing method for silver halide photographic light-sensitive material KONISHIROKU PHOTO IND (JP) 1997-10-08 EP disclosed
US-5618661-A SUPPORTING BY A STRETCHED STYRENE POLYMER; ANTIFOGGING, NONDEGRADING KONICA CORPORATION (JP) 1997-04-08 US disclosed
US-5571660-A Method for forming an image KONICA CORPORATION (JP) 1996-11-05 US disclosed
US-5527800-A A 4H-PYRROLO(3,2,1-IJ)QUINOLIN-8-YL DERIVATIVE ADMINISTERED FOR THERAPY OR PROPHYLAXIS OF SENILE DEMENTIA TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-06-18 US disclosed
EP-0713134-A1 Processing method for silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1996-05-22 EP disclosed
EP-0642055-A1 A method of forming an image KONICA CORPORATION (JP) 1995-03-08 EP disclosed
EP-0607864-A2 Tricyclic condensed heterocyclic compounds for the treatment of senile dementic Takeda Chemical Industries, Ltd. (JP) 1994-07-27 EP disclosed
US-4965182-A CYANINE DYES FUJI PHOTO FILM CO., LTD. (JP) 1990-10-23 US disclosed
JP-S6456660-A UREA DERIVATIVE OR ITS SALT, PRODUCTION THEREOF AND GERMICIDE FOR AGRICULTURE AND HORTICULTURE CONTAINING SAID DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT SUMITOMO CHEMICAL CO 1989-03-03 JP disclosed
EP-0301477-A2 Silver halide color photosensitive material and method of processing thereof Fuji Photo Film Co., Ltd. (JP) 1989-02-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007779-A1 CT CONTRAST AGENT FOR DETECTION OF CACHEXIA CPT1B, PNLIP, CPT1A CHRM2 812/4885CHRM1 937/4885CHRM3 1006/4885
US-11858887-B2 Linker compounds, methods of producing the same and uses thereof PAICS, CA1, ECPAS CHRM2 2630/4885CHRM1 2471/4885CHRM3 2273/4885
US-20250367307-A1 PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND/OR PREVENTION CAPRIN1, NOS1, NCBP1 CHRM2 2488/4885CHRM1 1079/4885CHRM3 1527/4885
US-20260092051-A1 PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CANCERS INCLUDING THE SAME FLT3, FLT1, ADK CHRM2 3981/4885CHRM1 4176/4885CHRM3 3037/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.