Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3279916

C[C@H](N)Cc1ccc(Cl)cc1.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 4/20 0.95
SLC6A3 known ✓ Q01959 2/20 0.95
SLC6A4 known ✓ P31645 3/20 0.64
MAOA known ✓ P21397 1/20 0.58
SIGMAR1 known ✓ Q99720 1/20 0.58
TAAR1 Q96RJ0 5/20 0.59
PNMT P11086 2/20 0.59
CYP2A6 P11509 1/20 0.58
ADORA2A P29274 1/20 0.58
ADORA1 P30542 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4363928 1.00 SLC6A2 (0.95) SLC6A2SLC6A3SLC6A4TAAR1PNMT
Hydrochloric Acid SCHEMBL1168686 1.00 SLC6A2 (0.95) SLC6A2SLC6A3SLC6A4TAAR1PNMT
Hydrochloric Acid SCHEMBL4519421 1.00 SLC6A2 (0.95) SLC6A2SLC6A3SLC6A4TAAR1PNMT
SCHEMBL267030 0.98 SLC6A2 (1.00) SLC6A2SLC6A3SLC6A4TAAR1PNMT
SCHEMBL586783 0.98 SLC6A2 (1.00) SLC6A2SLC6A3SLC6A4TAAR1PNMT
SCHEMBL22229845 0.98 SLC6A2 (1.00) SLC6A2SLC6A3SLC6A4TAAR1PNMT
Methane SCHEMBL19285556 0.95 SLC6A2 (0.95) SLC6A2SLC6A3SLC6A4TAAR1PNMT
SCHEMBL20714984 0.91 SLC6A2 (0.88) SLC6A2SLC6A3SLC6A4TAAR1PNMT
SCHEMBL9468251 0.91 SLC6A2 (0.88) SLC6A2SLC6A3SLC6A4TAAR1PNMT
Sulfuric Acid SCHEMBL11130866 0.86 SLC6A2 (0.78) SLC6A2SLC6A3SLC6A4TAAR1PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4122914-B1 COMPOUND AND METHOD FOR PREPARATION OF LISDEXAMFETAMINE SCI PHARMTECH INC (TW) 2023-08-16 EP disclosed
EP-4215517-A1 COMPOUND AND METHOD FOR PREPARATION OF LISDEXAMFETAMINE SCI Pharmtech Inc. (CN) 2023-07-26 EP disclosed
US-11608312-B1 Compound and method for preparation of lisdexamfetamine SCI PHARMTECH INC. (TW) 2023-03-21 US disclosed
US-20230084232-A1 COMPOUND AND METHOD FOR PREPARATION OF LISDEXAMFETAMINE SCI PHARMTECH INC. (TW) 2023-03-16 US disclosed
EP-4122914-A1 COMPOUND AND METHOD FOR PREPARATION OF LISDEXAMFETAMINE SCI Pharmtech Inc. (CN) 2023-01-25 EP disclosed
US-10544434-B2 Process for the preparation of lisdexamfetamine and related derivatives NORAMCO, INC. (US) 2020-01-28 US disclosed
WO-2017003721-A1 PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES NORAMCO, INC. (US) 2017-01-05 WO disclosed
US-20160376618-A1 PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES NORAMCO, LLC 2016-12-29 US disclosed
US-8614346-B2 Methods and compositions for preparation of amphetamine conjugates and salts thereof CAMBREX CHARLES CITY, INC. (US) 2013-12-24 US disclosed
US-20120190880-A1 METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF BLUE OWL CAPITAL CORPORATION, AS NEW AGENT 2012-07-26 US disclosed
WO-2010148305-A1 METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF CAMBREX CHARLES CITY, INC. (US) 2010-12-23 WO disclosed
US-7705184-B2 Method of making amphetamine CAMBREX CHARLES CITY, INC. (US) 2010-04-27 US disclosed
US-20090292143-A1 METHOD OF MAKING AMPHETAMINE CAMBREX CHARLES CITY (US) 2009-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190880-A1 METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF PNMT, COMT, DDT SLC6A2 25/4885SLC6A3 9/4885SLC6A4 101/4885
US-10544434-B2 Process for the preparation of lisdexamfetamine and related derivatives COMT, MGAM, GAA SLC6A2 14/4885SLC6A3 4/4885SLC6A4 9/4885
US-11608312-B1 Compound and method for preparation of lisdexamfetamine COMT, CYP2D6, SLC6A3 SLC6A2 11/4885SLC6A3 3/4885SLC6A4 54/4885
US-20160376618-A1 PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES COMT, MGAM, GAA SLC6A2 14/4885SLC6A3 4/4885SLC6A4 9/4885
US-20230084232-A1 COMPOUND AND METHOD FOR PREPARATION OF LISDEXAMFETAMINE COMT, CYP2D6, SLC6A3 SLC6A2 11/4885SLC6A3 3/4885SLC6A4 54/4885
US-20090292143-A1 METHOD OF MAKING AMPHETAMINE COMT, PNMT, CES2 SLC6A2 40/4885SLC6A3 7/4885SLC6A4 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.