Phenylalanine Amide

Phenylalanine Amide

SCHEMBL354542

Cl.NC(=O)[C@@H](N)Cc1ccccc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phenylalanine Amide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.70
HDAC8 known ✓ Q9BY41 2/20 0.56
SLC7A5 Q01650 2/20 0.70
ALPI P09923 1/20 0.70
PKM P14618 1/20 0.70
XIAP P98170 1/20 0.70
SLC15A1 P46059 1/20 0.59
EPHX1 P07099 2/20 0.58
LTA4H P09960 1/20 0.56
SLC1A3 P43003 2/20 0.55
SLC1A2 P43004 2/20 0.55
SLC1A1 P43005 2/20 0.55
CYP1A2 P05177 1/20 0.52
SRR Q9GZT4 1/20 0.52
LAP3 P28838 3/20 0.50
ANPEP P15144 1/20 0.50
CTSC P53634 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylalanine Amide SCHEMBL353593 1.00 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL23002157 1.00 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL2938353 1.00 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL11349868 0.98 SLC7A5 (0.73) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL244302 0.98 SLC7A5 (0.73) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL244303 0.98 SLC7A5 (0.73) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL353251 0.98 SLC7A5 (0.73) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL7613300 0.96 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL7613303 0.96 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine Amide SCHEMBL11569548 0.96 SLC7A5 (0.70) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 263 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0081838-B1 CYCLOHEXYL AND PHENYL SUBSTITUTED ENKEPHALINS G.D. Searle & Co. (US) 1988-04-27 EP claimed
US-12612429-B2 Derivatives of dolaproine-dolaisoleuine peptides AGENSYS, INC. (US) 2026-04-28 US disclosed
EP-4711010-A2 PRO-PERFUME COMPOSITIONS Firmenich SA (CH) 2026-03-18 EP disclosed
US-20260027071-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION COMPRISING AMIDATED AMINO ACID KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) 2026-01-29 US disclosed
US-12492160-B2 Prodrugs of itaconate and methyl itaconate THE JOHNS HOPKINS UNIVERSITY (US) 2025-12-09 US disclosed
US-20250263631-A1 PRO-PERFUME COMPOSITIONS FIRMENICH SA (CH) 2025-08-21 US disclosed
CN-120192243-A Prodrugs of itaconate and methyl itaconate 约翰霍普金斯大学 2025-06-24 CN disclosed
US-12325839-B2 Pro-perfume compositions FIRMENICH SA (CH) 2025-06-10 US disclosed
US-20250122238-A1 CRYSTALLINE DIPEPTIDES USEFUL IN THE SYNTHESIS OF ELAMIPRETIDE STEALTH BIOTHERAPEUTICS INC. 2025-04-17 US disclosed
CN-115052588-B Prodrugs of itaconate and methyl itaconate 约翰霍普金斯大学 2025-04-08 CN disclosed
EP-0317959-A2 Anti-ulcer composition Okamoto, Shosuke (JP) 1989-05-31 EP disclosed
US-4761495-A Method relating to preparation of aspartyl peptides ISOCHEM S.A. (FR) 1988-08-02 US disclosed
EP-0081838-B1 CYCLOHEXYL AND PHENYL SUBSTITUTED ENKEPHALINS G.D. Searle & Co. (US) 1988-04-27 EP disclosed
EP-0252670-A2 2-Substituted alkoxy-3-substituted-pyrazines TOYO JOZO KABUSHIKI KAISHA (JP) 1988-01-13 EP disclosed
EP-0245662-A1 p-Hydroxyphenylsulfonium salts and their use in the preparation of esters and amides SANSHIN KAGAKU KOGYO CO., LTD. (JP) 1987-11-19 EP disclosed
EP-0242957-A1 1-Substituted Alkyl-1, 2-Dihydro-2-Pyrazinone derivatives TOYO JOZO KABUSHIKI KAISHA (JP) 1987-10-28 EP disclosed
EP-0030847-B1 PHARMACOLOGICALLY ACTIVE PEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ELI LILLY AND COMPANY (US) 1984-05-30 EP disclosed
US-4333873-A ANALGESICS, TETRAPEPTIDES ENKEPHALIN ANALOGS ELI LILLY AND COMPANY (US) 1982-06-08 US disclosed
US-4283330-A ANALGESICS ELI LILLY AND COMPANY (US) 1981-08-11 US disclosed
EP-0030847-A2 Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them ELI LILLY AND COMPANY (US) 1981-06-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12492160-B2 Prodrugs of itaconate and methyl itaconate HADHA, IMPDH1, CYP27A1 PTGS1 142/4885HDAC8 477/4885SLC7A5 2200/4885
US-20250122238-A1 CRYSTALLINE DIPEPTIDES USEFUL IN THE SYNTHESIS OF ELAMIPRETIDE PEPD, DPP4, ANPEP PTGS1 3532/4885HDAC8 3169/4885SLC7A5 942/4885
US-20260027071-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION COMPRISING AMIDATED AMINO ACID COL2A1, COL14A1, GLS PTGS1 1080/4885HDAC8 3641/4885SLC7A5 1146/4885
US-12612429-B2 Derivatives of dolaproine-dolaisoleuine peptides DDOST, NGLY1, GRPR PTGS1 1996/4885HDAC8 2876/4885SLC7A5 414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.